Search Results - "Cheng, Robert Ys"

Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A by Waheed, Sana, Cheng, Robert Ys, Casablanca, Yovanni, Maxwell, G Larry, Wink, David A, Syed, Viqar

“…Nitric oxide (NO) is implicated in several biological processes, including cancer progression. At low concentrations, it promotes cell survival and tumor…”
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Multigenerational Epigenetic Regulation of Allergic Diseases: Utilizing an Experimental Dust Mite-Induced Asthma Model by Pulczinski, Jairus C, Shang, Yan, Dao, Tyna, Limjunyawong, Nathachit, Sun, Qinying, Mitzner, Wayne, Cheng, Robert Ys, Tang, Wan-Yee

“…Environmental exposures have been linked to increased asthma risk, particularly during pregnancy and in early life. Here we use a mouse model of allergic lung…”
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Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density by Somasundaram, Veena, Ridnour, Lisa A., Cheng, Robert YS, Walke, Abigail J., Kedei, Noemi, Bhattacharyya, Dibyangana D., Wink, Adelaide L., Edmondson, Elijah F., Butcher, Donna, Warner, Andrew C., Dorsey, Tiffany H., Scheiblin, David A., Heinz, William, Bryant, Richard J., Kinders, Robert J., Lipkowitz, Stanley, Wong, Stephen TC, Pore, Milind, Hewitt, Stephen M., McVicar, Daniel W., Anderson, Stephen K., Chang, Jenny, Glynn, Sharon A., Ambs, Stefan, Lockett, Stephen J., Wink, David A.

“…Antitumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An emerging concept influencing clinical outcome involves the spatial…”
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Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors by Weiss, Jonathan M, Davies, Luke C, Karwan, Megan, Ileva, Lilia, Ozaki, Michelle K, Cheng, Robert Ys, Ridnour, Lisa A, Annunziata, Christina M, Wink, David A, McVicar, Daniel W

“…Control of cellular metabolism is critical for efficient cell function, although little is known about the interplay between cell subset-specific metabolites…”
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Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism by Somasundaram, Veena, Basudhar, Debashree, Bharadwaj, Gaurav, No, Jae Hong, Ridnour, Lisa A, Cheng, Robert Y S, Fujita, Mayumi, Thomas, Douglas D, Anderson, Stephen K, McVicar, Daniel W, Wink, David A

“…Cancer is a complex disease, which not only involves the tumor but its microenvironment comprising different immune cells as well. Nitric oxide (NO) plays…”
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Nitric oxide and redox mechanisms in the immune response by Wink, David A., Hines, Harry B., Cheng, Robert Y. S., Switzer, Christopher H., Flores‐Santana, Wilmarie, Vitek, Michael P., Ridnour, Lisa A., Colton, Carol A.

“…Review discusses the chemistry of NO and ROS in the context of anti‐pathogen activity and immunoregulation. The role of redox molecules, such as NO and ROS, as…”
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Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers by de Oliveira, Graciele Almeida, Cheng, Robert Y S, Ridnour, Lisa A, Basudhar, Debashree, Somasundaram, Veena, McVicar, Daniel W, Monteiro, Hugo Pequeno, Wink, David A

“…Gastrointestinal (GI) cancer taken together constitutes one of the most common cancers worldwide with a broad range of etiological mechanisms. In this review,…”
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Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression by Heinecke, Julie L., Ridnour, Lisa A., Cheng, Robert Y. S., Switzer, Christopher H., Lizardo, Michael M., Khanna, Chand, Glynn, Sharon A., Hussain, S. Perwez, Young, Howard A., Ambs, Stefan, Wink, David A.

“…Inflammation is widely recognized as an inducer of cancer progression. The inflammation-associated enzyme, inducible nitric oxide synthase (NOS2), has emerged…”
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Human NUMB6 Induces Epithelial‐Mesenchymal Transition and Enhances Breast Cancer Cells Migration and Invasion by Karaczyn, Aldona A., Adams, Tamara L., Cheng, Robert Y.S., Matluk, Nicholas N., Verdi, Joseph M.

“…ABSTRACT Mammalian NUMB is alternatively spliced generating four isoforms NUMB1‐NUMB4 that can function as tumor suppressors. NUMB1‐NUMB4 proteins, which…”
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Alterations of the lung methylome in allergic airway hyper-responsiveness by Cheng, Robert YS, Shang, Yan, Limjunyawong, Nathachit, Dao, Tyna, Das, Sandhya, Rabold, Richard, Sham, James SK, Mitzner, Wayne, Tang, Wan-Yee

“…Asthma is a chronic airway disorder characterized by recurrent attacks of breathlessness and wheezing, affecting 300 million people around the world (available…”
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Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1 by Ridnour, Lisa A., Dhanapal, Sneha, Hoos, Michael, Wilson, Joan, Lee, Jennifer, Cheng, Robert Y. S., Brueggemann, Ernst E., Hines, Harry B., Wilcock, Donna M., Vitek, Michael P., Wink, David A., Colton, Carol A.

“…Fibrillar amyloid plaques are largely composed of amyloid‐beta (Aβ) peptides that are metabolized into products, including Aβ1‐16, by proteases including…”
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Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer by Ridnour, Lisa A, Heinz, William F, Cheng, Robert Ys, Wink, Adelaide L, Kedei, Noemi, Pore, Milind, Imtiaz, Fatima, Femino, Elise L, Gonzalez, Ana L, Coutinho, Leandro L, Moffat, Rebecca L, Butcher, Donna, Edmondson, Elijah F, Li, Xiaoxian, Rangel, Maria Cristina, Kinders, Robert J, Rittscher, Jens, Lipkowitz, Stanley, Wong, Stephen T C, Anderson, Stephen K, McVicar, Daniel W, Glynn, Sharon A, Billiar, Timothy R, Chang, Jenny C, Hewitt, Stephen M, Ambs, Stefan, Lockett, Stephen J, Wink, David A

“…Estrogen receptor-negative breast cancer is an aggressive subtype with limited therapeutic options. Elevated nitric oxide synthase (NOS2) and cyclo-oxygenase…”
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Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors by Ridnour, Lisa A, Cheng, Robert Ys, Kedei, Noemi, Somasundaram, Veena, Bhattacharyya, Dibyangana D, Basudhar, Debashree, Wink, Adelaide L, Walke, Abigail J, Kim, Caleb, Heinz, William F, Edmondson, Elijah F, Butcher, Donna O, Warner, Andrew C, Dorsey, Tiffany H, Pore, Milind, Kinders, Robert J, Lipkowitz, Stanley, Bryant, Richard J, Rittscher, Jens, Wong, Stephen Tc, Hewitt, Stephen M, Chang, Jenny C, Shalaby, Aliaa, Callagy, Grace M, Glynn, Sharon A, Ambs, Stefan, Anderson, Stephen K, McVicar, Daniel W, Lockett, Stephen J, Wink, David A

“…Immune therapy is the new frontier of cancer treatment. Therapeutic radiation is a known inducer of immune response and can be limited by immunosuppressive…”
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Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways by Cheng, Robert Y.S., Basudhar, Debashree, Ridnour, Lisa A., Heinecke, Julie L., Kesarwala, Aparna H., Glynn, Sharon, Switzer, Christopher H., Ambs, Stefan, Miranda, Katrina M., Wink, David A.

“…•The biological effects of NO and HNO are governed by their cellular concentrations, plus spatial and temporal distribution both within tumor cells and in the…”
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Increased Serum Corticosterone and Glucose in Offspring of Chromium(III)-Treated Male Mice by Robert Y. S. Cheng, Alvord, W. Gregory, Powell, Douglas, Kasprzak, Kazimierz S., Anderson, Lucy M.

“…Preconceptional carcinogenesis occurs in animals and is suspected for humans-for example, after occupational metals exposure. Several characteristics in animal…”
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