Search Results - "Cheng, Paul C."

Impact of Case and Control Selection on Training Artificial Intelligence Screening of Cardiac Amyloidosis by Vrudhula, Amey, Stern, Lily, Cheng, Paul C., Ricchiuto, Piero, Daluwatte, Chathuri, Witteles, Ronald, Patel, Jignesh, Ouyang, David

“…Recent studies suggest that cardiac amyloidosis (CA) is significantly underdiagnosed. For rare diseases like CA, the optimal selection of cases and controls…”
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Patterns of bisphosphonate treatment among patients with multiple myeloma treated at oncology clinics across the USA: observations from real-world data by Kim, Christopher, Hernandez, Rohini K., Cyprien, Lori, Liede, Alexander, Cheng, Paul C.

“…Purpose Current guidelines recommend that intravenous bisphosphonates be initiated in all patients with multiple myeloma for management of bone disease. The…”
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A role for lipid rafts in B cell antigen receptor signaling and antigen targeting by Cheng, P C, Dykstra, M L, Mitchell, R N, Pierce, S K

“…The B cell antigen receptor (BCR) serves both to initiate signal transduction cascades and to target antigen for processing and presentation by MHC class II…”
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The Role of the CD19/CD21 Complex in B Cell Processing and Presentation of Complement-Tagged Antigens by Cherukuri, Anu, Cheng, Paul C, Pierce, Susan K

“…The CD19/CD21 complex is an essential B cell coreceptor that functions synergistically to enhance signaling through the B cell Ag receptor in response to T…”
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The CD19/CD21 Complex Functions to Prolong B Cell Antigen Receptor Signaling from Lipid Rafts by Cherukuri, Anu, Cheng, Paul C., Sohn, Hae Won, Pierce, Susan K.

“…The CD19/CD21 complex functions to significantly enhance B cell antigen receptor (BCR) signaling in response to complement-tagged antigens. Recent studies…”
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Translocation of the B Cell Antigen Receptor into Lipid Rafts Reveals a Novel Step in Signaling by Cheng, Paul C, Brown, Bruce K, Song, Wenxia, Pierce, Susan K

“…The cross-linking of the B cell Ag receptor (BCR) leads to the initiation of a signal transduction cascade in which the earliest events involve the…”
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Floating the raft hypothesis: the roles of lipid rafts in B cell antigen receptor function by Cheng, Paul C., Cherukuri, Anu, Dykstra, Michelle, Malapati, Sunil, Sproul, Tim, Chen, Michael R., Pierce, Susan K.

“…The initiation of antibody responses to foreign antigens requires that B cells receive and integrate a variety of signals through an array of cell surface…”
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MHC Class II Antigen Processing in B Cells: Accelerated Intracellular Targeting of Antigens by Cheng, Paul C, Steele, Carrie R, Gu, Lin, Song, Wenxia, Pierce, Susan K

“…Processing and presentation by Ag-specific B cells is initiated by Ag binding to the B cell Ag receptor (BCR). Cross-linking of the BCR by Ag results in a…”
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Association of pretreatment (preTx) tumor characteristics and clinical outcomes following second-line (2L) axicabtagene ciloleucel (axi-cel) versus standard of care (SOC) in patients (pts) with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) by Locke, Frederick L., Chou, Justin, Vardhanabhuti, Saran, Perbost, Regis, Dreger, Peter, Hill, Brian T, Lee, Catherine, Zinzani, Pier Luigi, Kroeger, Nicolaus, López-Guillermo, Armando, Greinix, Hildegard, Zhang, Wangshu, Tiwari, Gayatri, To, Christina Ann, Cheng, Paul C., Bot, Adrian, Shen, Rhine, Filosto, Simone, Galon, Jerome

“…7565 Background: The Phase 3 randomized ZUMA-7 trial in 2L R/R LBCL showed axi-cel superiority to SOC (salvage chemotherapy and HDT-ASCT) in event-free…”
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Bone Targeting Agent Treatment Patterns Among Patients with Multiple Myeloma Treated at Oncology Clinics Across the United States: Observations from Real-World Data by Kim, Christopher, Hernandez, Rohini K., Cheng, Paul C, Smith, Jeremy, Cyprien, Lori, Liede, Alexander

“…Introduction: Multiple myeloma (MM) is a hematologic malignancy with 30,330 estimated new cases in the US in 2016. The International Myeloma Working Group…”
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A Role for MHC Class II Antigen Processing in B Cell Development by Sproul, Tim W., Cheng, Paul C., Dykstra, Michelle L., Pierce, Susan K.

“…For mature B cells, the encounter with foreign antigen results in the selective expansion of the cells and their differentiation into antibody secreting cells…”
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Impact of denosumab (DMB) compared with zoledronic acid (ZA) on renal function in the treatment of myeloma bone disease by Raje, Noopur S., Roodman, G. David, Willenbacher, Wolfgang, Shimizu, Kazuyuki, Garcia-Sanz, Ramon, Durie, Brian G., Zhu, Li, Cheng, Paul C., Bhatta, Sumita, Terpos, Evangelos

“…Abstract only 8005 Background: Osteolytic bone disease and renal dysfunction are complications of multiple myeloma. ZA, used for the prevention and treatment…”
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ZUMA-7: A phase 3 randomized trial of axicabtagene ciloleucel (Axi-Cel) versus standard-of-care (SOC) therapy in patients with relapsed/refractory diffuse large B cell lymphoma (R/R DLBCL) by Oluwole, Olalekan O., Bishop, Michael Russell, Gisselbrecht, Christian, Gordon, Leo I., Kersten, Marie Jose, Maloney, David G., Schmitz, Norbert, Caballero Barrigon, María Dolores, Kuruvilla, John, Song, Kevin W., Jacobson, Caron A., Nastoupil, Loretta J., Riedell, Peter, Jiang, Yizhou, Rossi, John M., Lee, Lillian, Cheng, Paul C., Locke, Frederick Lundry

“…Abstract only…”
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Trafficking of the Igα/Igβ Heterodimer with Membrane Ig and Bound Antigen to the Major Histocompatibility Complex Class II Peptide-loading Compartment by Bruce K. Brown, Chang Li, Paul C. Cheng, Wenxia Song

“…The binding of antigen to the B cell antigen receptor (BCR) initiates two major cellular events. First, upon cross-linking by antigen, the BCR induces signal…”
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Trafficking of the Igα/Igβ Heterodimer with Membrane Ig and Bound Antigen to the Major Histocompatibility Complex Class II Peptide-loading Compartment by Brown, Bruce K., Li, Chang, Cheng, Paul C., Song, Wenxia

“…The binding of antigen to the B cell antigen receptor (BCR) initiates two major cellular events. First, upon cross-linking by antigen, the BCR induces signal…”
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