Search Results - "Cheng, Menyan"

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold by Cheng, Menyan, De, Biswanath, Almstead, Neil G, Pikul, Stanislaw, Dowty, Martin E, Dietsch, Charles R, Dunaway, C. Michelle, Gu, Fei, Hsieh, Lily C, Janusz, Michael J, Taiwo, Yetunde O, Natchus, Michael G, Hudlicky, Tomas, Mandel, Martin

“…The synthesis and structure−activity relationship (SAR) studies of a series of proline-based matrix metalloproteinase inhibitors are described. The data reveal…”
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Design and synthesis of conformationally-constrained MMP inhibitors by Natchus, Michael G., Cheng, Menyan, Wahl, Christopher T., Pikul, Stanislaw, Almstead, Neil G., Bradley, Rimma S., Taiwo, Yetunde O., Mieling, Glen E., Dunaway, C.Michelle, Snider, Catherine E., McIver, John M., Barnett, Bobby L., McPhail, Sara J., Anastasio, Melanie B., De, Biswanath

“…A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly…”
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1,6-Addition of organocopper reagents to 3-alkynyl-2-cycloalkenones: regiospecific syntheses of dienones and allenes by Cheng, Menyan, Hulce, Martin

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Bridged .gamma.-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors by Mewshaw, Richard E, Silverman, Lisa S, Mathew, Rose M, Kaiser, Carl, Sherrill, Ronald G, Cheng, Menyan, Tiffany, Carol W, Karbon, E. William, Bailey, Michael A

“…A series of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles and 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indoles was prepared. Structural…”
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Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors by Cheng, Menyan, De, Biswanath, Pikul, Stanislaw, Almstead, Neil G, Natchus, Michael G, Anastasio, Melanie V, McPhail, Sara J, Snider, Catherine E, Taiwo, Yetunde O, Chen, Longyin, Dunaway, C. Michelle, Gu, Fei, Dowty, Martin E, Mieling, Glen E, Janusz, Michael J, Wang-Weigand, Sherry

“…A new generation of cyclic matrix metalloproteinase (MMP) inhibitors derived from dl-piperazinecarboxylic acid has been described. The design involves: …”
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The Next Generation of MMP Inhibitors: Design and Synthesis by DE, BISWANATH, NATCHUS, MICHAEL G., CHENG, MENYAN, PIKUL, STANISLAW, ALMSTEAD, NEIL G., TAIWO, YETUNDE O., SNIDER, CATHERINE E., CHEN, LONGYIN, BARNETT, BOBBY, GU, FEI, DOWTY, MARTIN

“…Since their inception during the eighties, MMP inhibitors (MMPIs) have gone through several cycles of metamorphosis. The design of early MMPIs was based on the…”
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Oxazolidinone to succinamide: a novel rearrangement reaction by Cheng, Menyan, De, Biswanath, Wahl, Christopher T., Almstead, Neil G., Natchus, Michael G., Pikul, Stanislaw

“…During the course of an investigative work with a monosubstituted succinic acid half-ester tethered to a chiral oxazolidinone, an unexpected disubstituted…”
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