Search Results - "Cheng, Maosheng"

Synthetic Approaches to Tetracyclic Indolines as Versatile Building Blocks of Diverse Indole Alkaloids by Wang, Yanshi, Xie, Fukai, Lin, Bin, Cheng, Maosheng, Liu, Yongxiang

“…Indole alkaloids bearing the tetracyclic indoline scaffolds of 1H‐pyrrolo[2,3‐d]carbazole have shown fascinating chemical diversity and significant biological…”
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The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network by Cheng, Maosheng, Sheng, Lu, Gao, Qian, Xiong, Qiuchan, Zhang, Haojie, Wu, Mingqing, Liang, Yu, Zhu, Fengyu, Zhang, Yingyin, Zhang, Xiuhong, Yuan, Quan, Li, Yang

“…N 6 -methyladenosine (m6A) is the most abundant modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its…”
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Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment by Liu, Tian, Li, Lingxiao, Wang, Shuo, Dong, Fudan, Zuo, Shiyi, Song, Jiaxuan, Wang, Xin, Lu, Qi, Wang, Helin, Zhang, Haotian, Cheng, Maosheng, Liu, Xiaohong, He, Zhonggui, Sun, Bingjun, Sun, Jin

“…Sulfur bonds, especially trisulfide bond, have been found to ameliorate the self-assembly stability of homodimeric prodrug nanoassemblies and could trigger the…”
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Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression by Chen, Jie, Li, Kang, Chen, Jianwen, Wang, Xiaochen, Ling, Rongsong, Cheng, Maosheng, Chen, Zhi, Chen, Fangfang, He, Qianting, Li, Shuai, Zhang, Caihua, Jiang, Yizhou, Chen, Qianming, Wang, Anxun, Chen, Demeng

“…Background Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed…”
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Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety by Tian, Xing, Sun, Zihan, Zhong, Ye, Yang, Huali, Cheng, Maosheng, Liu, Yang

“…A series of novel echinatin derivatives with 1,3,4-oxadiazole moieties were designed and synthesized. Most of the newly synthesized compounds exhibited…”
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ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4+ macrophage infiltration by Zhang, Caihua, Li, Kang, Zhu, Hongzhang, Cheng, Maosheng, Chen, Shuang, Ling, Rongsong, Wang, Cheng, Chen, Demeng

“…Enoblituzumab, an immunotherapeutic agent targeting CD276, shows both safety and efficacy in activating T cells and oligodendrocyte-like cells against various…”
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Immobilization of molybdenum-based complexes on dendrimer-functionalized graphene oxide and their catalytic activity for the epoxidation of alkenes by Fan, Zhanfang, Lin, Bin, Liu, Yongqing, Liu, Yang, Cheng, Maosheng

“…Two novel molybdenum-based heterogeneous catalysts immobilized on dendrimer-functionalized graphene oxide via electrostatic interactions (Mo-1) or covalent…”
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Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation by Yang, Lu, Su, Hongwei, Sun, Yue, Zhang, Sen, Cheng, Maosheng, Liu, Yongxiang

“…Gold catalysts possess the advantages of water and oxygen resistance, with the possibility of catalyzing many novel chemical transformations, especially in the…”
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Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis by Yin, Wenbo, Wu, Tianxiao, Liu, Lei, Jiang, Hong, Zhang, Yuxin, Cui, Hengxian, Sun, Yin, Qin, Qiaohua, Sun, Yixiang, Gao, Zixuan, Zhao, Liyu, Su, Xin, Zhao, Dongmei, Cheng, Maosheng

“…Invasive fungal infections are emerging as serious infectious diseases worldwide. Because of the development of antifungal drug resistance, the limited…”
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Diastereoselective Syntheses of Spiro[indoline-3,4′-pyridin]-2-yl Carbamates via AgOTf/Ph3P‑Catalyzed Tandem Cyclizations of Tryptamine-Ynesulfonamides by Liang, Guoduan, Pang, Yadong, Ji, Yanjun, Zhuang, Kaitong, Li, Linji, Xie, Fukai, Yang, Lu, Cheng, Maosheng, Lin, Bin, Liu, Yongxiang

“…Spiro­[indoline-3,4′-piperidine] is a significant structural scaffold in numerous polycyclic indole alkaloids with a variety of bioactivities. In this study, a…”
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Computational Strategy Revealing the Structural Determinant of Ligand Selectivity towards Highly Similar Protein Targets by Wang, Hanxun, Gao, Yinli, Wang, Jian, Cheng, Maosheng

“…Poor selectivity of drug candidates may lead to toxicity and side effects accounting for as high as 60% failure rate, thus, the selectivity is consistently…”
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METTL3-mediated m6A mRNA modification promotes esophageal cancer initiation and progression via Notch signaling pathway by Han, Hui, Yang, Chunlong, Zhang, Shuishen, Cheng, Maosheng, Guo, Siyao, Zhu, Yan, Ma, Jieyi, Liang, Yu, Wang, Lu, Zheng, Siyi, Wang, Zhaoyu, Chen, Demeng, Jiang, Yi-Zhou, Lin, Shuibin

“…Esophageal cancer is a lethal malignancy with a high mortality rate, while the molecular mechanisms underlying esophageal cancer pathogenesis are still poorly…”
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Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability by Yi, Ce, Xie, Fei, Xu, Xin, Xiao, Dian, Zhou, Xinbo, Cheng, Maosheng

“…Aiming to address the insufficient endocytosis ability of traditional albumin drug conjugates, this paper reports elegant guanidine modification to improve…”
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Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer's disease by Yang, Huali, Jia, Hongwei, Deng, Minghui, Zhang, Kaicheng, Liu, Yaoyang, Liu, Yang, Cheng, Maosheng, Xiao, Wei

“…A series of OA-tacrine hybrids with the alkylamine linker was designed, synthesized, and evaluated as effective cholinesterase inhibitors for the treatment of…”
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The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma by Li, Kang, Chen, Jie, Zhang, Caihua, Cheng, Maosheng, Chen, Shuang, Song, Wei, Yang, Chunlong, Ling, Rongsong, Chen, Zhi, Wang, Xiaochen, Xiong, Gan, Ma, Jieyi, Zhu, Yan, Yuan, Quan, Liu, Qi, Peng, Liang, Chen, Qianming, Chen, Demeng

“…PCIF1 can mediate the methylation of N6,2'-O-dimethyladenosine (m6Am) in mRNA. Yet, the detailed interplay between PCIF1 and the potential cofactors and its…”
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Synthesis, Molecular Docking Analysis, and Biological Evaluations of Saccharide-Modified Sulfonamides as Carbonic Anhydrase IX Inhibitors by Zhang, Zuopeng, Yang, Huali, Zhong, Ye, Wang, Yueqing, Wang, Jian, Cheng, Maosheng, Liu, Yang

“…Based on the strategy of the "tail approach", 15 novel saccharide-modified sulfonamides were designed and synthesised. The novel compounds were evaluated as…”
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Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells by Wu, Mingqing, Sheng, Lu, Cheng, Maosheng, Zhang, Haojie, Jiang, Yizhou, Lin, Shuibin, Liang, Yu, Zhu, Fengyu, Liu, Zhenqing, Zhang, Yingyin, Zhang, Xiuhong, Gao, Qian, Chen, Demeng, Li, Jiong, Li, Yang

“…Low dose treatment with the DNA methylation inhibitor decitabine has been shown to be applicable for the management of certain types of cancer. However, its…”
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Brønsted Acid‐Catalyzed Tandem Cyclizations of Tryptamine‐Ynamides Yielding 1H‐Pyrrolo[2,3‐d]carbazole Derivatives by Wang, Yanshi, Lin, Jingsheng, Wang, Xiaoyu, Wang, Guanghui, Zhang, Xinhang, Yao, Bo, Zhao, Yuandong, Yu, Pengfei, Lin, Bin, Liu, Yongxiang, Cheng, Maosheng

“…Ynamides, as versatile synthetic precursors, have attracted much attention from synthetic chemists and sparked the development of a number of methodologies for…”
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Structure-Based Design of 6‑Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors by Hao, Chenzhou, Zhao, Fan, Song, Hongyan, Guo, Jing, Li, Xiaodong, Jiang, Xiaolin, Huan, Ran, Song, Shuai, Zhang, Qiaoling, Wang, Ruifeng, Wang, Kai, Pang, Yu, Liu, Tongchao, Lu, Tianqi, Huang, Wanxu, Wang, Jian, Lin, Bin, He, Zhonggui, Li, Haitao, Li, Feng, Zhao, Dongmei, Cheng, Maosheng

“…Herein, we report the discovery and characterization of a novel class of PAK4 inhibitors with a quinazoline scaffold. Based on the shape and chemical…”
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CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer by Cheng, Maosheng, Chen, Shuang, Li, Kang, Wang, Ganping, Xiong, Gan, Ling, Rongsong, Zhang, Caihua, Zhang, Zhihui, Han, Hui, Chen, Zhi, Wang, Xiaochen, Liang, Yu, Tian, Guoli, Zhou, Ruoxing, Zhu, Yan, Ma, Jieyi, Liu, Jiahong, Lin, Shuibin, Xu, Hao, Chen, Demeng, Li, Yang, Peng, Liang

“…Interplay between innate and adaptive immune cells is important for the antitumor immune response. However, the tumor microenvironment may turn immune…”
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