Search Results - "Cheng, Keman"

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology by Cheng, Keman, Zhao, Ruifang, Li, Yao, Qi, Yingqiu, Wang, Yazhou, Zhang, Yinlong, Qin, Hao, Qin, Yuting, Chen, Long, Li, Chen, Liang, Jie, Li, Yujing, Xu, Jiaqi, Han, Xuexiang, Anderson, Gregory J., Shi, Jian, Ren, Lei, Zhao, Xiao, Nie, Guangjun

“…An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed. Outer membrane vesicles (OMVs) can strongly activate the innate…”
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Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy by Cheng, Keman, Ding, Yanping, Zhao, Ying, Ye, Shefang, Zhao, Xiao, Zhang, Yinlong, Ji, Tianjiao, Wu, Huanhuan, Wang, Bin, Anderson, Gregory J, Ren, Lei, Nie, Guangjun

“…Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials…”
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Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field by Ma, Xiaotu, Liang, Xiaolong, Li, Yao, Feng, Qingqing, Cheng, Keman, Ma, Nana, Zhu, Fei, Guo, Xinjing, Yue, Yale, Liu, Guangna, Zhang, Tianjiao, Liang, Jie, Ren, Lei, Zhao, Xiao, Nie, Guangjun

“…Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression and drug release…”
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A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment by Zhao, Xiao, Liu, Liang, Lang, Jiayan, Cheng, Keman, Wang, Yongwei, Li, Xueyan, Shi, Jian, Wang, Yanli, Nie, Guangjun

“…Mutant KRAS is a known driver oncogene in pancreatic cancer. However, this protein remains an “undruggable” therapeutic target. Inhibiting mutated KRAS…”
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Development of a Cancer Vaccine Using In Vivo Click‐Chemistry‐Mediated Active Lymph Node Accumulation for Improved Immunotherapy by Qin, Hao, Zhao, Ruifang, Qin, Yuting, Zhu, Jin, Chen, Long, Di, Chunzhi, Han, Xuexiang, Cheng, Keman, Zhang, Yinlong, Zhao, Ying, Shi, Jian, Anderson, Gregory J., Zhao, Yuliang, Nie, Guangjun

“…Due to their ability to elicit a potent immune reaction with low systemic toxicity, cancer vaccines represent a promising strategy for treating tumors…”
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A recent advancement in the delivery of CAR‐T: Use lyophilized lymph nodes by Du, Xinze, Cheng, Keman, Zhao, Xiao

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Rationally designed multimeric nanovaccines using icosahedral DNA origami for display of SARS-CoV-2 receptor binding domain by Feng, Qingqing, Cheng, Keman, Zhang, Lizhuo, Wang, Dongshu, Gao, Xiaoyu, Liang, Jie, Liu, Guangna, Ma, Nana, Xu, Chen, Tang, Ming, Chen, Liting, Wang, Xinwei, Ma, Xuehui, Zou, Jiajia, Shi, Quanwei, Du, Pei, Wang, Qihui, Wang, Hengliang, Nie, Guangjun, Zhao, Xiao

“…Multivalent antigen display on nanoparticles can enhance the immunogenicity of nanovaccines targeting viral moieties, such as the receptor binding domain (RBD)…”
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Author Correction: Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field by Ma, Xiaotu, Liang, Xiaolong, Li, Yao, Feng, Qingqing, Cheng, Keman, Ma, Nana, Zhu, Fei, Guo, Xinjing, Yue, Yale, Liu, Guangna, Zhang, Tianjiao, Liang, Jie, Ren, Lei, Zhao, Xiao, Nie, Guangjun

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Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer by Li, Qinglin, Zhang, Lizhuo, Lang, Jiayan, Tan, Zhuo, Feng, Qingqing, Zhu, Fei, Liu, Guangna, Ying, Zhangguo, Yu, Xuefei, Feng, He, Yi, Heqing, Wen, Qingliang, Jin, Tiefeng, Cheng, Keman, Zhao, Xiao, Ge, Minghua

“…Restoring sodium iodide symporter (NIS) expression and function remains a major challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more…”
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Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells by Liang, Jie, Cheng, Keman, Li, Yao, Xu, Jiaqi, Chen, Yiwei, Ma, Nana, Feng, Qingqing, Zhu, Fei, Ma, Xiaotu, Zhang, Tianjiao, Yue, Yale, Liu, Guangna, Guo, Xinjing, Chen, Zhiqiang, Wang, Xinwei, Zhao, Ruifang, Zhao, Ying, Shi, Jian, Zhao, Xiao, Nie, Guangjun

“…Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen, thus efficiently facilitating…”
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Injectable Immunotherapeutic Hydrogel Containing RNA-Loaded Lipid Nanoparticles Reshapes Tumor Microenvironment for Pancreatic Cancer Therapy by Gao, Chao, Cheng, Keman, Li, Yao, Gong, Ruining, Zhao, Xiao, Nie, Guangjun, Ren, He

“…Pancreatic cancer immunotherapy is becoming a promising strategy for improving the survival rate of postsurgical patients. However, the low response rate to…”
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Biogenic nanoparticles as immunomodulator for tumor treatment by Cheng, Keman, Kang, Qinglin, Zhao, Xiao

“…In the past few decades, cancer immunotherapy has developed rapidly. Cancer immunotherapy, either used alone or in combination with a variety of…”
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Biomimetic Metal–Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy by Min, Huan, Wang, Jing, Qi, Yingqiu, Zhang, Yinlong, Han, Xuexiang, Xu, Ying, Xu, Junchao, Li, Yao, Chen, Long, Cheng, Keman, Liu, Guangna, Yang, Na, Li, Yiye, Nie, Guangjun

“…Photodynamic therapy (PDT) is a promising anticancer treatment and is clinically approved for different types of tumors. However, current PDT suffers several…”
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Engineered Bacterial Outer Membrane Vesicles as Controllable Two‐Way Adaptors to Activate Macrophage Phagocytosis for Improved Tumor Immunotherapy by Feng, Qingqing, Ma, Xiaotu, Cheng, Keman, Liu, Guangna, Li, Yao, Yue, Yale, Liang, Jie, Zhang, Lizhuo, Zhang, Tianjiao, Wang, Xinwei, Gao, Xiaoyu, Nie, Guangjun, Zhao, Xiao

“…The most immune cells infiltrating tumor microenvironment (TME), tumor‐associated macrophages (TAMs) closely resemble immunosuppressive M2‐polarized…”
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A Graphdiyne Oxide‐Based Iron Sponge with Photothermally Enhanced Tumor‐Specific Fenton Chemistry by Min, Huan, Qi, Yingqiu, Zhang, Yinlong, Han, Xuexiang, Cheng, Keman, Liu, Ying, Liu, Huibiao, Hu, Jianshe, Nie, Guangjun, Li, Yiye

“…Fenton reaction‐mediated oncotherapy is an emerging strategy which uses iron ions to catalytically convert endogenous hydrogen peroxide into hydroxyl radicals,…”
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Antigen Capture and Immune Modulation by Bacterial Outer Membrane Vesicles as In Situ Vaccine for Cancer Immunotherapy Post‐Photothermal Therapy by Li, Yao, Zhang, Kaiyue, Wu, Yao, Yue, Yale, Cheng, Keman, Feng, Qingqing, Ma, Xiaotu, Liang, Jie, Ma, Nana, Liu, Guangna, Nie, Guangjun, Ren, Lei, Zhao, Xiao

“…Tumor antigens released from tumor cells after local photothermal therapy (PTT) can activate the tumor‐specific immune responses, which are critical for…”
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Rapid Surface Display of mRNA Antigens by Bacteria‐Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine by Li, Yao, Ma, Xiaotu, Yue, Yale, Zhang, Kaiyue, Cheng, Keman, Feng, Qingqing, Ma, Nana, Liang, Jie, Zhang, Tianjiao, Zhang, Lizhuo, Chen, Zhiqiang, Wang, Xinwei, Ren, Lei, Zhao, Xiao, Nie, Guangjun

“…Therapeutic mRNA vaccination is an attractive approach to trigger antitumor immunity. However, the mRNA delivery technology for customized tumor vaccine is…”
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A Bioinspired Nanoprobe with Multilevel Responsive T 1 -Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases by Li, Yao, Zhao, Xiao, Liu, Xiaoli, Cheng, Keman, Han, Xuexiang, Zhang, Yinlong, Min, Huan, Liu, Guangna, Xu, Junchao, Shi, Jian, Qin, Hao, Fan, Haiming, Ren, Lei, Nie, Guangjun

“…Metastasis remains the major cause of death in cancer patients. Thus, there is a need to sensitively detect tumor metastasis, especially ultrasmall metastasis,…”
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Drug conjugate-based anticancer therapy - Current status and perspectives by Yang, Yuqi, Wang, Shuhang, Ma, Peiwen, Jiang, Yale, Cheng, Keman, Yu, Yue, Jiang, Ning, Miao, Huilei, Tang, Qiyu, Liu, Funan, Zha, Yan, Li, Ning

“…Drug conjugates are conjugates comprising a tumor-homing carrier tethered to a cytotoxic agent via a linker that are designed to deliver an ultra-toxic payload…”
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Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy by Yang, Na, Ding, Yanping, Zhang, Yinlong, Wang, Bin, Zhao, Xiao, Cheng, Keman, Huang, Yixin, Taleb, Mohammad, Zhao, Jing, Dong, Wen-Fei, Zhang, Lirong, Nie, Guangjun

“…Multiple cell plasma membranes have been utilized for surface functionalization of synthetic nanomaterials and construction of biomimetic drug delivery systems…”
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