Photosensitizers with aggregation-induced far-red/near-infrared emission for versatile visualization and broad-spectrum photodynamic killing of pathogenic microbes

Photosensitizers with aggregation-induced far-red/near-infrared emission for versatile visualization and broad-spectrum photodynamic killing of pathogenic microbes

[Display omitted] The exploration of photosensitizers with aggregation-induced emission (AIE PSs) for efficient visualization and broad-spectrum photodynamic killing of pathogenic microbes is a significant task. Herein, two far-red/near-infrared AIE-active PSs (TBTPy and TBTCy) were attained to show...

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Bibliographic Details
Published in:Journal of colloid and interface science Vol. 634; pp. 664 - 674
Main Authors: Luo, Jiabao, Yang, Ping, Cheng, Jingxi, Fan, Jiaqi, Zhou, Weiying, Lu, Yaru, Xie, XiaoBao, Wu, Wenbo, Zhang, Xinguo
Format: Journal Article
Language:English
Published: United States Elsevier Inc 15-03-2023
Subjects:
Aggregation-induced emission
Animals
Anti-Infective Agents - pharmacology
Antimicrobial
Broad-spectrum
Candida albicans
Drug-resistance
Escherichia coli
Mammals
Methicillin-Resistant Staphylococcus aureus
Photochemotherapy
Photodynamic killing
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Rats
Reactive Oxygen Species
Staphylococcus aureus
Visualization
Antimicrobial
Visualization
Photodynamic killing
Aggregation-induced emission
Drug-resistance
Broad-spectrum
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Summary:[Display omitted] The exploration of photosensitizers with aggregation-induced emission (AIE PSs) for efficient visualization and broad-spectrum photodynamic killing of pathogenic microbes is a significant task. Herein, two far-red/near-infrared AIE-active PSs (TBTPy and TBTCy) were attained to show efficient Type I and Type II ROS generation, benefiting from the efficient ISC processes. The attained AIE PSs, especially TBTPy with bright emission, showed advantages in discriminating G+ bacteria over G− bacteria, and distinguishing dead E. coli from lived one. Both TBTPy and TBTCy have the capacity of broad-spectrum photodynamic killing of pathogenic microbes in vitro with considerable safety for mammalian cells. Antimicrobial mechanism is found to be changing osmotic pressure of cytoplasm in E. coli, causing cell deformation and destruction of S. aureus and C. albicans. In vivo anti-infection experiment demonstrated AIE PSs can accelerate the healing process of the burned wounds on rats infected by methicillin-resistant S. aureus (MRSA) or E. coli, indicating their potential to treat tertiary burns in clinical application. Therefore, the attained AIE PSs hold great promise as antimicrobial candidates in infective therapeutic application.
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content type line 23
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2022.12.062