Search Results - "Cheng, Jin Q"

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner by Guo, Jianping, Chakraborty, Abhishek A., Liu, Pengda, Gan, Wenjian, Zheng, Xingnan, Inuzuka, Hiroyuki, Wang, Bin, Zhang, Jinfang, Zhang, Linli, Yuan, Min, Novak, Jesse, Cheng, Jin Q., Toker, Alex, Signoretti, Sabina, Zhang, Qing, Asara, John M., Kaelin, William G., Wei, Wenyi

“…Activation of the serine-threonine kinase Akt promotes the survival and proliferation of various cancers. Hypoxia promotes the resistance of tumor cells to…”
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MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA by Kong, William, Yang, Hua, He, Lili, Zhao, Jian-jun, Coppola, Domenico, Dalton, William S., Cheng, Jin Q.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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MicroRNA Expression Profiling in Human Ovarian Cancer : miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN by HUA YANG, KONG, William, CHENG, Jin Q, LILI HE, ZHAO, Jian-Jun, O'DONNELL, Joshua D, JIAWANG WANG, WENHAM, Robert M, COPPOLA, Domenico, KRUK, Patricia A, NICOSIA, Santo V

“…MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of gene expression. Recently, miRNAs have been implicated in several…”
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microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma by Zhao, Jian-Jun, Lin, Jianhong, Lwin, Tint, Yang, Hua, Guo, Jianping, Kong, William, Dessureault, Sophie, Moscinski, Lynn C., Rezania, Dorna, Dalton, William S., Sotomayor, Eduardo, Tao, Jianguo, Cheng, Jin Q.

“…Mantle cell lymphoma (MCL) is one of the most aggressive B-cell lymphomas. Although several protein-coding genes are altered, expression signature and…”
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IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation by Guo, Jian-Ping, Coppola, Domenico, Cheng, Jin Q.

“…Serine/threonine kinase Akt regulates key cellular processes such as cell growth, proliferation, and survival. Activation of Akt by mitogenic factor depends on…”
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Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function by Cheng, George Z., Zhang, WeiZhou, Sun, Mei, Wang, Qi, Coppola, Domenico, Mansour, Mena, Xu, LiMei, Costanzo, Carliann, Cheng, Jin Q., Wang, Lu-Hai

“…To explore the basis of metastasis, we compared the human breast cancer lines MCF-7 and MDA-MB453, which have low invasive ability, with their sublines MCF7-I4…”
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Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma by Zhao, Jian-Jun, Chu, Zhang-Bo, Hu, Yu, Lin, Jianhong, Wang, Zhongqiu, Jiang, Meng, Chen, Ming, Wang, Xujun, Kang, Yue, Zhou, Yangsheng, Ni Chonghaile, Triona, Johncilla, Melanie E, Tai, Yu-Tzu, Cheng, Jin Q, Letai, Antony, Munshi, Nikhil C, Anderson, Kenneth C, Carrasco, Ruben D

“…Despite recent therapeutic advances that have doubled the median survival time of patients with multiple myeloma, intratumor genetic heterogeneity contributes…”
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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation by Mahajan, Kiran, Coppola, Domenico, Challa, Sridevi, Fang, Bin, Chen, Y Ann, Zhu, Weiwei, Lopez, Alexis S, Koomen, John, Engelman, Robert W, Rivera, Charlene, Muraoka-Cook, Rebecca S, Cheng, Jin Q, Schönbrunn, Ernst, Sebti, Said M, Earp, H Shelton, Mahajan, Nupam P

“…The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development…”
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The Akt PKB pathway: molecular target for cancer drug discovery by Cheng, Jin Q, Lindsley, Craig W, Cheng, George Z, Yang, Hua, Nicosia, Santo V

“…The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular therapeutics, as it functions as a cardinal nodal point for…”
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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways by QING XU, BRIGGS, Jon, CHENG, Jin Q, JOVE, Richard, HUA YU, PARK, Sungman, GUILIAN NIU, KORTYLEWSKI, Marcin, SHUMIN ZHANG, GRITSKO, Tanya, TURKSON, James, KAY, Heidi, SEMENZA, Gregg L

“…Vascular endothelial growth factor (VEGF) upregulation is induced by many receptor and intracellular oncogenic proteins commonly activated in cancer, rendering…”
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Deregulated Akt3 activity promotes development of malignant melanoma by STAHL, Jill M, SHARMA, Arati, CHEUNG, Mitchell, ZIMMERMAN, Melissa, CHENG, Jin Q, BOSENBERG, Marcus W, KESTER, Mark, SANDIRASEGARANE, Lakshman, ROBERTSON, Gavin P

“…Malignant melanoma is the skin cancer with the most significant impact on man, carrying the highest risk of death from metastasis. Both incidence and mortality…”
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Action of the src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells by NAM, Sangkil, KIM, Donghwa, CHENG, Jin Q, SHUMIN ZHANG, LEE, Ji-Hyun, BUETTNER, Ralf, MIROSEVICH, Janni, LEE, Francis Y, JOVE, Richard

“…Src family kinases (SFK) are currently being investigated as targets for treatment strategies in various cancers. The novel SFK/Abl inhibitor, dasatinib…”
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IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function by Guo, Jian-Ping, Tian, Wei, Shu, Shaokun, Xin, Yu, Shou, Chengchao, Cheng, Jin Q

“…Forkhead box O (FOXO) transcription factors are emerging as key regulators of cell survival and growth. The transcriptional activity and subcellular…”
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Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215 by Liu, Qiyuan, Kaneko, Satoshi, Yang, Lin, Feldman, Richard I, Nicosia, Santo V, Chen, Jiandong, Cheng, Jin Q

“…The tumor suppressor p53 is important in the decision to either arrest cell cycle progression or induce apoptosis in response to a variety of stimuli. p53…”
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Akt and CHIP Coregulate Tau Degradation through Coordinated Interactions by Dickey, Chad A., Koren, John, Zhang, Yong-Jie, Xu, Ya-fei, Jinwal, Umesh K., Birnbaum, Morris J., Monks, Bobby, Sun, Mei, Cheng, Jin Q., Patterson, Cam, Bailey, Rachel M., Dunmore, Judith, Soresh, Sareh, Leon, Carlos, Morgan, Dave, Petrucelli, Leonard

“…A hallmark of the pathology of Alzheimer's disease is the accumulation of the microtubule-associated protein tau into fibrillar aggregates. Recent studies…”
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Aurora‐A induces cell survival and chemoresistance by activation of Akt through a p53‐dependent manner in ovarian cancer cells by Yang, Hua, He, Lili, Kruk, Patricia, Nicosia, Santo V., Cheng, Jin Q.

“…Aurora‐A is frequently altered in epithelial malignancies. Overexpressing Aurora‐A induces centrosome amplification and G2/M cell cycle progression. We have…”
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Indirubin Derivatives Inhibit Stat3 Signaling and Induce Apoptosis in Human Cancer Cells by Nam, Sangkil, Buettner, Ralf, Turkson, James, Kim, Donghwa, Cheng, Jin Q., Muehlbeyer, Stephan, Hippe, Frankie, Vatter, Sandra, Merz, Karl-Heinz, Eisenbrand, Gerhard, Jove, Richard, Vogt, Peter K.

“…Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal…”
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Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance by Koren, 3rd, John, Miyata, Yoshinari, Kiray, Janine, O'Leary, 3rd, John C, Nguyen, Lana, Guo, Jianping, Blair, Laura J, Li, Xiaokai, Li, Xiokai, Jinwal, Umesh K, Cheng, Jin Q, Gestwicki, Jason E, Dickey, Chad A

“…MKT-077, a rhodacyanine dye, was shown to produce cancer specific cell death. However, complications prevented the use of this compound beyond clinical trials…”
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High resolution of microRNA signatures in human whole saliva by Patel, Rushi S, Jakymiw, Andrew, Yao, Bing, Pauley, Brad A, Carcamo, Wendy C, Katz, Joseph, Cheng, Jin Q, Chan, Edward K.L

“…Abstract Objective Identifying discriminatory human salivary RNA biomarkers reflective of disease in a low-cost non-invasive screening assay is crucial to…”
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Akt Phosphorylation and Stabilization of X-linked Inhibitor of Apoptosis Protein (XIAP) by Dan, Han C., Sun, Mei, Kaneko, Satoshi, Feldman, Richard I., Nicosia, Santo V., Wang, Hong-Gang, Tsang, Benjamin K., Cheng, Jin Q.

“…Akt negatively regulates apoptotic pathways at a premitochondrial level through phosphorylation and modulation of proteins such as Bad, Forkhead proteins, and…”
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