Search Results - "Cheng, Jeffrey P."

Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury by Amirbekyan, Mari, Adhikarla, Vikram, Cheng, Jeffrey P., Moschonas, Eleni H., Bondi, Corina O., Rockne, Russell C., Kline, Anthony E., Gutova, Margarita

“…Efficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful delivery, migration, and engraftment of stem cells to induce…”
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Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology by Anderson, Eric N, Morera, Andrés A, Kour, Sukhleen, Cherry, Jonathan D, Ramesh, Nandini, Gleixner, Amanda, Schwartz, Jacob C, Ebmeier, Christopher, Old, William, Donnelly, Christopher J, Cheng, Jeffrey P, Kline, Anthony E, Kofler, Julia, Stein, Thor D, Pandey, Udai Bhan

“…Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease…”
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Intranasally Administered L-Myc-Immortalized Human Neural Stem Cells Migrate to Primary and Distal Sites of Damage after Cortical Impact and Enhance Spatial Learning by Gutova, Margarita, Cheng, Jeffrey P., Adhikarla, Vikram, Tsaturyan, Lusine, Barish, Michael E., Rockne, Russell C., Moschonas, Eleni H., Bondi, Corina O., Kline, Anthony E.

“…As the success of stem cell-based therapies is contingent on efficient cell delivery to damaged areas, neural stem cells (NSCs) have promising therapeutic…”
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Antipsychotic Drugs: The Antithesis to Neurorehabilitation in Models of Pre-Clinical Traumatic Brain Injury by Race, Nicholas S, Moschonas, Eleni H, Cheng, Jeffrey P, Bondi, Corina O, Kline, Anthony E

“…Sixty-nine million traumatic brain injuries (TBIs) are reported worldwide each year, and, of those, close to 3 million occur in the United States. In addition…”
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Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury by Kline, Anthony E., Hoffman, Ann N., Cheng, Jeffrey P., Zafonte, Ross D., Massucci, Jaime L.

“…Antipsychotics are often administered to traumatic brain injured (TBI) patients as a means of controlling agitation, albeit the rehabilitative consequences of…”
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Environmental enrichment improves traumatic brain injury-induced behavioral phenotype and associated neurodegenerative process by Tapias, Victor, Moschonas, Eleni H., Bondi, Corina O., Vozzella, Vincent J., Cooper, Iya N., Cheng, Jeffrey P., Lajud, Naima, Kline, Anthony E.

“…Traumatic brain injury (TBI) causes persistent cognitive impairment and neurodegeneration. Environmental enrichment (EE) refers to a housing condition that…”
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Early Life Stress Preceding Mild Pediatric Traumatic Brain Injury Increases Neuroinflammation but Does Not Exacerbate Impairment of Cognitive Flexibility during Adolescence by Lajud, Naima, Roque, Angélica, Cheng, Jeffrey P, Bondi, Corina O, Kline, Anthony E

“…Early life stress (ELS) followed by pediatric mild traumatic brain injury (mTBI) negatively impacts spatial learning and memory and increases microglial…”
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Environmental enrichment, alone or in combination with various pharmacotherapies, confers marked benefits after traumatic brain injury by de la Tremblaye, Patricia B., Cheng, Jeffrey P., Bondi, Corina O., Kline, Anthony E.

“…Traumatic brain injury (TBI) is a significant health care issue that affects over ten million people worldwide. Treatment options are limited with numerous…”
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Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury by Ji, Jing, Kline, Anthony E, Amoscato, Andrew, Samhan-Arias, Alejandro K, Sparvero, Louis J, Tyurin, Vladimir A, Tyurina, Yulia Y, Fink, Bruno, Manole, Mioara D, Puccio, Ava M, Okonkwo, David O, Cheng, Jeffrey P, Alexander, Henry, Clark, Robert S B, Kochanek, Patrick M, Wipf, Peter, Kagan, Valerian E, Bayır, Hülya

“…The authors show that traumatic brain injury can induce peroxidation of cardiolipin, leading to accumulation of numerous oxygenated species and the induction…”
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Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better? by Kline, Anthony E, Leary, Jacob B, Radabaugh, Hannah L, Cheng, Jeffrey P, Bondi, Corina O

“…Traumatic brain injury (TBI) is a significant health care crisis that affects two million individuals in the United Sates alone and over ten million worldwide…”
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Delayed-and-abbreviated environmental enrichment after traumatic brain injury confers neurobehavioral benefits similar to immediate-and-continuous exposure by Bittner, Rachel A., Greene, Anna M., Leary, Jacob B., Donald, Hailey M., Capeci, Haley E., Moschonas, Eleni H., Cheng, Jeffrey P., Bondi, Corina O., Kline, Anthony E.

“…•Immediate-and-continuous environmental enrichment (EE) confers significant benefits after TBI.•Delayed-and abbreviated EE provides comparable benefits to…”
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Pre-operative environmental enrichment does not yield a prophylactic effect against traumatic brain injury-induced neurobehavioral deficits by Moschonas, Eleni H., Steber, Jade A., Capeci, Haley E., Donald, Hailey M., Vozzella, Vincent J., Bittner, Rachel A., Annas, Ellen M., Rennerfeldt, Piper L., Cheng, Jeffrey P., Bondi, Corina O., Kline, Anthony E.

“…The robustness of environmental enrichment (EE) in ameliorating neurobehavioral and cognitive deficits after experimental traumatic brain injury (TBI) is…”
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Environmental enrichment and amantadine confer individual but nonadditive enhancements in motor and spatial learning after controlled cortical impact injury by Bleimeister, Isabel H., Wolff, Mia, Lam, Tracey R., Brooks, Derrick M., Patel, Reece, Cheng, Jeffrey P., Bondi, Corina O., Kline, Anthony E.

“…•Amantadine (AMT) improved motor and cognitive performance after TBI.•Environmental enrichment (EE) improved motor and cognitive performance after TBI.•No…”
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A combined therapeutic regimen of citalopram and environmental enrichment ameliorates attentional set-shifting performance after brain trauma by Minchew, Heather M., Radabaugh, Hannah L., LaPorte, Megan L., Free, Kristin E., Cheng, Jeffrey P., Bondi, Corina O.

“…Traumatic brain injuries (TBI) have led to lasting deficits for an estimated 5.3 million American patients. Effective therapies for these patients remain…”
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Enriching adult male rats prior to traumatic brain injury does not attenuate neurobehavioral or histological deficits by Moschonas, Eleni H., Niesman, Peter J., Vozzella, Vincent J., Bittner, Rachel A., Brennan, Connor J., Cheng, Jeffrey P., Bondi, Corina O., Kline, Anthony E.

“…•No prophylactic effect was observed by enriching rats prior to TBI.•Pre-TBI EE rats did not differ in any endpoint from standard-housed rats.•Enriching rats…”
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Early life stress increases vulnerability to the sequelae of pediatric mild traumatic brain injury by Diaz-Chávez, Arturo, Lajud, Naima, Roque, Angélica, Cheng, Jeffrey P., Meléndez-Herrera, Esperanza, Valdéz-Alarcón, Juan José, Bondi, Corina O., Kline, Anthony E.

“…Early life stress (ELS) is a risk factor for many psychopathologies that happen later in life. Although stress can occur in cases of child abuse, studies on…”
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Chronic unpredictable stress during adolescence protects against adult traumatic brain injury-induced affective and cognitive deficits by de la Tremblaye, Patricia B., Wellcome, JoDy L., Wiley, Kaitlyn, Lomahan, Carolyn A., Moschonas, Eleni H., Cheng, Jeffrey P., Bondi, Corina O., Kline, Anthony E.

“…•TBI produces affective and cognitive deficits.•CUS for 4 weeks during adolescence protects against adult TBI.•The cannabinoid receptor 1 (CB1) agonist ACEA…”
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Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: An initial foray into a novel and non-pharmacological rehabilitative therapy by Moschonas, Eleni H., Ranellone, Tyler S., Vozzella, Vincent J., Rennerfeldt, Piper L., Bondi, Corina O., Annas, Ellen M., Bittner, Rachel A., Tamura, Dana M., Reddy, Rithika I., Eleti, Rithik R., Cheng, Jeffrey P., Jarvis, Jessica M., Fink, Ericka L., Kline, Anthony E.

“…Traumatic brain injury (TBI) causes neurobehavioral and cognitive impairments that negatively impact life quality for millions of individuals. Because of its…”
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Chronic treatment with galantamine rescues reversal learning in an attentional set-shifting test after experimental brain trauma by Njoku, Ihuoma, Radabaugh, Hannah L., Nicholas, Melissa A., Kutash, Lindsay A., O'Neil, Darik A., Marshall, Ian P., Cheng, Jeffrey P., Kline, Anthony E., Bondi, Corina O.

“…Approximately 10 million new cases of traumatic brain injury (TBI) are reported each year worldwide with many of these injuries resulting in higher order…”
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Repetitive Mild Traumatic Brain Injury in the Developing Brain: Effects on Long-Term Functional Outcome and Neuropathology by Fidan, Emin, Lewis, Jesse, Kline, Anthony E, Garman, Robert H, Alexander, Henry, Cheng, Jeffrey P, Bondi, Corina O, Clark, Robert S B, Dezfulian, Cameron, Kochanek, Patrick M, Kagan, Valerian E, Bayır, Hülya

“…Although accumulating evidence suggests that repetitive mild TBI (rmTBI) may cause long-term cognitive dysfunction in adults, whether rmTBI causes similar…”
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