Search Results - "Cheng, Heng Jie"

3D bioprinted functional and contractile cardiac tissue constructs by Wang, Zhan, Lee, Sang Jin, Cheng, Heng-Jie, Yoo, James J., Atala, Anthony

“…[Display omitted] Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro…”
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Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice by Mikhailov, Alexei V., Liu, Yixi, Cheng, Heng-Jie, Lin, Jen-Jar, Cheng, Che Ping

“…Calcium-calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes mellitus (DM), leading to the overproduction of collagen in the myocardium…”
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β3-Adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure by Masutani, Satoshi, Cheng, Heng-Jie, Morimoto, Atsushi, Hasegawa, Hiroshi, Han, Qing-Hua, Little, William C, Cheng, Che Ping

“…In heart failure (HF), the impaired left ventricular (LV) arterial coupling and diastolic dysfunction present at rest are exacerbated during exercise. We have…”
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Levosimendan restores the positive force-frequency relation in heart failure by Masutani, Satoshi, Cheng, Heng-Jie, Tachibana, Hideo, Little, William C, Cheng, Che-Ping

“…Frequency potentiation of contractile function is a major mechanism of the increase in myocardial performance during exercise. In heart failure (HF), this…”
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Upregulation of Functional β3-Adrenergic Receptor in the Failing Canine Myocardium by Cheng, Heng-Jie, Zhang, Zhu-Shan, Onishi, Katsuya, Ukai, Tomohiko, Sane, David C, Cheng, Che-Ping

“…ABSTRACT—Altered expression and functional responses to cardiac β3-adrenergic receptors (ARs) may contribute to progressive cardiac dysfunction in heart…”
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Angiotensin II Type 1 receptor blockade prevents alcoholic cardiomyopathy by CHENG, Che-Ping, CHENG, Heng-Jie, CUNNINGHAM, Carol, SHIHABI, Zakariya K, SANE, David C, WANNENBURG, Thomas, LITTLE, William C

“…Activation of the renin-angiotensin system (RAS) may contribute to the development of alcoholic cardiomyopathy. We evaluated the effect of angiotensin II (Ang…”
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Up-Regulation and Functional Effect of Cardiac β3-Adrenoreceptors in Alcoholic Monkeys by Cheng, Heng-Jie, Grant, Kathleen A., Han, Qing-Hua, Daunais, James B., Friedman, David P., Masutani, Satoshi, Little, William C., Cheng, Che-Ping

“…Background:  Recent studies link altered cardiac β‐adrenergic receptor (AR) signaling to the pathology of alcoholic cardiomyopathy (ACM). However, the…”
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Chronic GPR30 agonist therapy causes restoration of normal cardiac functional performance in a male mouse model of progressive heart failure: Insights into cellular mechanisms by Zhang, Xiaowei, Li, Tiankai, Cheng, Heng-Jie, Wang, Hao, Ferrario, Carlos M., Groban, Leanne, Cheng, Che Ping

“…G protein-coupled estrogen receptor 30 (GPR30) activation by its agonist, G1, exhibits beneficial actions in female with heart failure (HF). Recent evidence…”
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Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure by Tachibana, Hideo, Cheng, Heng-Jie, Ukai, Tomohiko, Igawa, Akihiko, Zhang, Zhu-Shan, Little, William C, Cheng, Che-Ping

“…The new myofilament Ca2+ sensitizer levosimendan (LSM) is a positive inotropic and vasodilatory agent. Its beneficial effects have been demonstrated at rest in…”
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Internalization of Angiotensin‐(1‐12) in Adult Retinal Pigment Epithelial‐19 Cells by Ahmad, Sarfaraz, Wright, Kendra N., Ferrario, Carlos M., Cheng, Heng‐Jie, Choudhary, Mayur, Malek, Goldis, Sappington, Rebecca M.

“…Introduction The characterization, by this laboratory, of angiotensin‐(1‐12) [Ang‐(1‐12)] as a primary angiotensin II (Ang II)‐forming substrate may be an…”
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Reversal of angiotensin-(1–12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis by Li, Tiankai, Zhang, Zhi, Zhang, Xiaowei, Chen, Zhe, Cheng, Heng-Jie, Ahmad, Sarfaraz, Ferrario, Carlos M., Cheng, Che Ping

“…Angiotensin-(1–12) [Ang-(1–12)] is a renin-independent precursor for direct angiotensin-II production by chymase. Substantial evidence suggests that heart…”
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Critical role of the chymase/angiotensin-(1–12) axis in modulating cardiomyocyte contractility by Li, Tiankai, Zhang, Xiaowei, Cheng, Heng-Jie, Zhang, Zhi, Ahmad, Sarfaraz, Varagic, Jasmina, Li, Weimin, Cheng, Che Ping, Ferrario, Carlos M.

“…Angiotensin-(1–12) [Ang-(1–12)] is a chymase-dependent source for angiotensin II (Ang II) cardiac activity. The direct contractile effects of Ang-(1–12) in…”
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Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs by Masutani, Satoshi, Cheng, Heng-Jie, Hyttilä-Hopponen, Minja, Levijoki, Jouko, Heikkilä, Aira, Vuorela, Arja, Little, William C, Cheng, Che-Ping

“…Levosimendan (LS), a Ca(2+) sensitizer, is presently limited to i.v. administration. The dose-related pharmacodynamic effects of newly developed oral LS remain…”
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Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure by Zhang, Xiaowei, Cheng, Heng-Jie, Zhou, Peng, Kitzman, Dalane W, Ferrario, Carlos M, Li, Wei-Min, Cheng, Che Ping

“…Abstract Background Angiotensin-(1-7) [Ang-(1-7)] exhibits cardiovascular effects opposite those of angiotensin II (Ang II), thus providing protection against…”
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Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism by Shao, Qun, Cheng, Heng-Jie, Callahan, Michael F, Kitzman, Dalane W, Li, Wei-Min, Cheng, Che Ping

“…ABSTRACT Background Altered nitric oxide synthase (NOS) has been implicated in the pathophysiology of heart failure (HF). Recent evidence links hypothyroidism…”
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Increased CaMKII activation and contrast changes of cardiac β1-and β3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension by Sun, Xiaoqiang, Cao, Jing, Chen, Zhe, Liu, Yixi, VonCannon, Jessica L., Cheng, Heng Jie, Ferrario, Carlos M., Cheng, Che Ping

“…Upregulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) contributes to the pathogenesis of cardiovascular disease, including hypertension…”
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C-Type Natriuretic Peptide Improves Left Ventricular Functional Performance at Rest and Restores Normal Exercise Responses after Heart Failure by Li, Tiankai, Cheng, Heng-Jie, Ohte, Nobuyuki, Hasegawa, Hiroshi, Morimoto, Atsushi, Herrington, David M, Little, William C, Li, Weimin, Cheng, Che Ping

“…In heart failure (HF), the impaired left ventricular (LV) arterial coupling and diastolic dysfunction present at rest are exacerbated during exercise. C-type…”
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The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure by Cheng, C P, Ukai, T, Onishi, K, Ohte, N, Suzuki, M, Zhang, Z S, Cheng, H J, Tachibana, H, Igawa, A, Little, W C

“…The diastolic dysfunction present at rest in congestive heart failure (CHF) is exacerbated during exercise (Ex). Increases in circulating ANG II and…”
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Restrictive Left Ventricular Filling Pattern Does Not Result From Increased Left Atrial Pressure Alone by MASUTANI, Satoshi, LITTLE, William C, HASEGAWA, Hiroshi, CHENG, Heng-Jie, CHENG, Che-Ping

“…The restrictive filling pattern seen with severe heart failure (HF) may be due to diastolic dysfunction with elevated left ventricular (LV) diastolic pressure…”
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Diastolic mitral annular velocity during the development of heart failure by HASEGAWA, Hiroshi, LITTLE, William C, OHNO, Michiya, BRUCKS, Steffen, MORIMOTO, Atsushi, CHENG, Heng-Jie, CHENG, Che-Ping

“…We sought to investigate the mechanism of reduced diastolic mitral annular velocity with diastolic dysfunction, despite elevated left atrial (LA) pressure. The…”
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