Search Results - "Cheng, Genhong"

Sequence analysis of the emerging SARS‐CoV‐2 variant Omicron in South Africa by Wang, Lulan, Cheng, Genhong

“…Despite the worldwide vaccination, the COVID‐19 pandemic continues as SARS‐CoV‐2 evolves into numerous variants. Since the first identification of the novel…”
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The Roles of Type I Interferon in Bacterial Infection by Boxx, Gayle M., Cheng, Genhong

“…Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the induction of a potent antiviral gene program essential for host…”
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Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China by Wu, Aiping, Peng, Yousong, Huang, Baoying, Ding, Xiao, Wang, Xianyue, Niu, Peihua, Meng, Jing, Zhu, Zhaozhong, Zhang, Zheng, Wang, Jiangyuan, Sheng, Jie, Quan, Lijun, Xia, Zanxian, Tan, Wenjie, Cheng, Genhong, Jiang, Taijiao

“…An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome…”
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Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A by Lv, Hongming, Yang, Huahong, Wang, Zhongfeng, Feng, Haihua, Deng, Xuming, Cheng, Genhong, Ci, Xinxin

“…Licochalcone A (Lico A), isolated from Xinjiang licorice Glycyrrhiza inflate, has been shown to have antioxidative potential via the activation of nuclear…”
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Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species by Atarashi, Koji, Tanoue, Takeshi, Shima, Tatsuichiro, Imaoka, Akemi, Kuwahara, Tomomi, Momose, Yoshika, Cheng, Genhong, Yamasaki, Sho, Saito, Takashi, Ohba, Yusuke, Taniguchi, Tadatsugu, Takeda, Kiyoshi, Hori, Shohei, Ivanov, Ivaylo I, Umesaki, Yoshinori, Itoh, Kikuji, Honda, Kenya

“…CD4⁺ T regulatory cells (Tregs), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show…”
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Systematic identification of type I and type II interferon-induced antiviral factors by Liu, Su-Yang, Sanchez, David Jesse, Aliyari, Roghiyh, Lu, Sun, Cheng, Genhong

“…Type I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought…”
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When Hepatitis B Virus Meets Interferons by Tan, Guangyun, Song, Hongxiao, Xu, Fengchao, Cheng, Genhong

“…Chronic hepatitis B virus (HBV) infection imposes a severe burden on global public health. Currently, there are no curative therapies for millions of chronic…”
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Modulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK by Guo, Beichu, Cheng, Genhong

“…Induction of type I interferons can be triggered by viral components through Toll-like receptors or intracellular viral receptors such as retinoic…”
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Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages by Iyer, Shankar Subramanian, Ghaffari, Amir Ali, Cheng, Genhong

“…IL-10 is a potent anti-inflammatory molecule that regulates excessive production of inflammatory cytokines during an infection or tissue damage. Dysregulation…”
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Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection by Wilson, Elizabeth B., Yamada, Douglas H., Elsaesser, Heidi, Herskovitz, Jonathan, Deng, Jane, Cheng, Genhong, Aronow, Bruce J., Karp, Christopher L., Brooks, David G.

“…Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease…”
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25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor by Zu, Shulong, Deng, Yong-Qiang, Zhou, Chao, Li, Jie, Li, Lili, Chen, Qi, Li, Xiao-Feng, Zhao, Hui, Gold, Sarah, He, Jun, Li, Xiang, Zhang, Changqing, Yang, Heng, Cheng, Genhong, Qin, Cheng-Feng

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Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons by Deriu, Elisa, Boxx, Gayle M, He, Xuesong, Pan, Calvin, Benavidez, Sammy David, Cen, Lujia, Rozengurt, Nora, Shi, Wenyuan, Cheng, Genhong

“…Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also develop gastrointestinal symptoms, such as…”
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Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle by He, Xuesong, McLean, Jeffrey S., Edlund, Anna, Yooseph, Shibu, Hall, Adam P., Liu, Su-Yang, Dorrestein, Pieter C., Esquenazi, Eduardo, Hunter, Ryan C., Cheng, Genhong, Nelson, Karen E., Lux, Renate, Shi, Wenyuan

“…The candidate phylum TM7 is globally distributed and often associated with human inflammatory mucosal diseases. Despite its prevalence, the TM7 phylum remains…”
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The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice by Guo, Beichu, Chang, Elmer Y, Cheng, Genhong

“…IFN-beta, a type I IFN, is widely used for the treatment of MS. However, the mechanisms behind its therapeutic efficacy are not well understood. Using a murine…”
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Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS by Ma, Feng, Li, Bing, Liu, Su-yang, Iyer, Shankar S, Yu, Yongxin, Wu, Aiping, Cheng, Genhong

“…Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate immune response. It has been well demonstrated that cyclic…”
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PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins by Li, Lili, Zhao, Hui, Liu, Ping, Li, Chunfeng, Quanquin, Natalie, Ji, Xue, Sun, Nina, Du, Peishuang, Qin, Cheng-Feng, Lu, Ning, Cheng, Genhong

“…Zika virus infection stimulates a type I interferon (IFN) response in host cells, which suppresses viral replication. Type I IFNs exert antiviral effects by…”
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MicroRNA-155 is induced during the macrophage inflammatory response by O'Connell, Ryan M, Taganov, Konstantin D, Boldin, Mark P, Cheng, Genhong, Baltimore, David

“…The mammalian inflammatory response to infection involves the induction of several hundred genes, a process that must be carefully regulated to achieve…”
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Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation by Zhang, Lixia, Yuan, Shunzong, Cheng, Genhong, Guo, Beichu

“…Whereas the immune system is essential for host defense against pathogen infection or endogenous danger signals, dysregulated innate and adaptive immune cells…”
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Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients by Li, Lili, Li, Jie, Gao, Meiling, Fan, Huimin, Wang, Yanan, Xu, Xin, Chen, Chunfeng, Liu, Junxiao, Kim, Jocelyn, Aliyari, Roghiyh, Zhang, Jicai, Jin, Yujie, Li, Xiaorong, Ma, Feng, Shi, Minxin, Cheng, Genhong, Yang, Heng

“…The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has…”
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Will Hydroxychloroquine Still Be a Game-Changer for COVID-19 by Combining Azithromycin? by Li, Chunfeng, Cheng, Genhong

“…Recent small-scale clinical trials have shown promising results in the use of hydroxychloroquine, an FDA approved anti-malaria drug, for the treatment of…”
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