Search Results - "Cheng, Furong"

The role of alpha-synuclein in neurotransmission and synaptic plasticity by Cheng, Furong, Vivacqua, Giorgio, Yu, Shun

“…► Molecular structures of α-syn relevant to its functional characteristics. ► The role of α-syn in synaptic vesicle recycling, neurotransmission and synaptic…”
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Responsive Multivesicular Polymeric Nanovaccines that Codeliver STING Agonists and Neoantigens for Combination Tumor Immunotherapy by Su, Ting, Cheng, Furong, Qi, Jialong, Zhang, Yu, Zhou, Shurong, Mei, Lei, Fu, Shiwei, Zhang, Fuwu, Lin, Shuibin, Zhu, Guizhi

“…Immune checkpoint blockade (ICB) has significantly advanced cancer immunotherapy, yet its patient response rates are generally low. Vaccines, including…”
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Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy by Su, Ting, Liu, Xiang, Lin, Shuibin, Cheng, Furong, Zhu, Guizhi

“…Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines. Here, we report ionizable polymeric nanoparticles that co-deliver…”
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Polymer Structure‐Guided Self‐Assisted Preparation of Poly(ester‐thioether)‐Based Hollow Porous Microspheres and Hierarchically Interconnected Microcages for Drug Release by Cheng, Furong, Su, Ting, Pu, Yuji, Gao, Wenxia, He, Bin

“…Porous polymer microspheres (PPMs) have been widely applied in various biomedical fields. Herein, the self‐assisted preparation of poly(ester‐thioether)‐based…”
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Targeting Lymph Nodes for Systemic Immunosuppression Using Cell-Free-DNA-Scavenging And cGAS-Inhibiting Nanomedicine-In-Hydrogel for Rheumatoid Arthritis Immunotherapy by Cheng, Furong, Su, Ting, Liu, Yangtengyu, Zhou, Shurong, Qi, Jialong, Guo, Weisheng, Zhu, Guizhi

“…Rheumatoid arthritis (RA) is a systemic autoimmune disease with pathogenic inflammation caused partly by excessive cell-free DNA (cfDNA). Specifically, cfDNA…”
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Integrative single-cell transcriptomic analyses reveal the cellular ontological and functional heterogeneities of primary and metastatic liver tumors by Gui, Menghui, Huang, Shilin, Li, Shizhou, Chen, Yuying, Cheng, Furong, Liu, Yulin, Wang, Ji-Ao, Wang, Yuting, Guo, Rui, Lu, Yiming, Cao, Pengbo, Zhou, Gangqiao

“…The global cellular landscape of the tumor microenvironment (TME) combining primary and metastatic liver tumors has not been comprehensively characterized…”
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Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy by Zhou, Shurong, Su, Ting, Cheng, Furong, Cole, Janet, Liu, Xiang, Zhang, Bei, Alam, Shaheer, Liu, Jinze, Zhu, Guizhi

“…Activating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) holds great potential for cancer immunotherapy by eliciting type-I interferon…”
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α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity by Liu, Guangwei, Zhang, Chunyan, Yin, Juanjuan, Li, Xin, Cheng, Furong, Li, Yaohua, Yang, Hui, Uéda, Kenji, Chan, Piu, Yu, Shun

“…α-Synuclein (α-Syn) abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). A link between α-Syn…”
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α‐Synuclein promotes clathrin‐mediated NMDA receptor endocytosis and attenuates NMDA‐induced dopaminergic cell death by Cheng, Furong, Li, Xin, Li, Yaohua, Wang, Chaodong, Wang, Tao, Liu, Guangwei, Baskys, Andrius, Uéda, Kenji, Chan, Piu, Yu, Shun

“…J. Neurochem. (2011) 119, 815–825. Abnormalities of α‐synuclein (α‐syn) and NMDA receptors (NMDARs) are implicated in the pathogenesis of Parkinson’s disease…”
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Engineering and Delivery of cGAS-STING Immunomodulators for the Immunotherapy of Cancer and Autoimmune Diseases by Zhou, Shurong, Cheng, Furong, Zhang, Yu, Su, Ting, Zhu, Guizhi

“…Conspectus The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING) pathway is an emerging therapeutic target for the prophylaxis and therapy of a…”
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C-terminal part of alpha-synuclein mediates its activity in promoting proliferation of dopaminergic cells by Yin, Juanjuan, Wang, Tao, Han, Junyan, Zhang, Chen, Ma, Qiulan, Li, Xin, Cheng, Furong, Liu, Guangwei, Li, Yaohua, Uéda, Kenji, Chan, Piu, Yu, Shun

“…α-Syn has been shown to exhibit a MAP-like activity and promote the assembly of microtubules. Since microtubules play a pivotal role in proliferative cell…”
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Reversing Chemotherapy Resistance by a Synergy between Lysosomal pH-Activated Mitochondrial Drug Delivery and Erlotinib-Mediated Drug Efflux Inhibition by Cheng, Furong, Pan, Qingqing, Gao, Wenxia, Pu, Yuji, Luo, Kui, He, Bin

“…Mitochondrial drug delivery has attracted increasing attention in various mitochondrial dysfunction-associated disorders such as cancer owing to the important…”
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Polymeric micelles amplify tumor oxidative stresses through combining PDT and glutathione depletion for synergistic cancer chemotherapy by Su, Ting, Cheng, Furong, Pu, Yuji, Cao, Jun, Lin, Shuibin, Zhu, Guizhi, He, Bin

“…•A star-shape polymer based on the Passerini three-component reaction was synthesized.•The ‘‘ROS threshold concept’’ was proposed by combining PDT with GSH…”
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In vitro and in vivo anti-tumor efficiency comparison of phosphorylcholine micelles with PEG micelles by Cai, Mengtan, Cao, Jun, Wu, Zhengzhong, Cheng, Furong, Chen, Yuanwei, Luo, Xianglin

“…[Display omitted] •The comparison of PCL-PEG micelles and PCL-PMPC micelles were detail evaluated and analyzed in vitro and in vivo.•PCL-PMPC micelles that…”
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Correction to “Reversing Chemotherapy Resistance by a Synergy between Lysosomal pH-Activated Mitochondrial Drug Delivery and Erlotinib-Mediated Drug Efflux Inhibition” by Cheng, Furong, Pan, Qingqing, Gao, Wenxia, Pu, Yuji, Luo, Kui, He, Bin

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Single-dose injectable nanovaccine-in-hydrogel for robust immunotherapy of large tumors with abscopal effect by Cheng, Furong, Su, Ting, Zhou, Shurong, Liu, Xiang, Yang, Suling, Lin, Shuibin, Guo, Weisheng, Zhu, Guizhi

“…Current cancer immunotherapy [e.g., immune checkpoint blockade (ICB)] only benefits small subsets of patients, largely due to immunosuppressive tumor…”
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Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery by Yan, Jianqin, Su, Ting, Cheng, Furong, Cao, Jun, Zhang, Hai, He, Bin

“…[Display omitted] •Imine-bond was introduced in PEI grafted polymer to construct pH-sensitive drug delivery.•The nanoparticles were coated with hyaluronic acid…”
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Characteristic of core materials in polymeric micelles effect on their micellar properties studied by experimental and dpd simulation methods by Cheng, Furong, Guan, Xuewa, Cao, Huan, Su, Ting, Cao, Jun, Chen, Yuanwei, Cai, Mengtan, He, Bin, Gu, Zhongwei, Luo, Xianglin

“…[Display omitted] Polymeric micelles are one important class of nanoparticles for anticancer drug delivery, but the impact of hydrophobic segments on drug…”
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Poly(ester-thioether) microspheres co-loaded with erlotinib and α-tocopheryl succinate for combinational therapy of non-small cell lung cancer by Cheng, Furong, Peng, Xinyu, Meng, Guolong, Pu, Yuji, Luo, Kui, He, Bin

“…Polymer microspheres are attracting wide attention in localized cancer therapy owing to the excellent biocompatibility and drug loading capacity, controllable…”
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Lymph node-targeting adjuvant/neoantigen-codelivering vaccines for combination glioblastoma radioimmunotherapy by Su, Ting, Zhou, Shurong, Yang, Suling, Humble, Nicholas, Zhang, Fuwu, Yu, Guocan, Bos, Paula D., Cheng, Furong, Valerie, Kristoffer, Zhu, Guizhi

“…Glioblastoma multiforme (GBM) is the most common and lethal type of adult brain cancer. Current GBM standard of care, including radiotherapy, often ends up…”
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