Search Results - "Cheng, Congsheng"

High-fidelity SaCas9 identified by directional screening in human cells by Xie, Haihua, Ge, Xianglian, Yang, Fayu, Wang, Bang, Li, Shuang, Duan, Jinzhi, Lv, Xiujuan, Cheng, Congsheng, Song, Zongming, Liu, Changbao, Zhao, Junzhao, Zhang, Yu, Wu, Jinyu, Gao, Caixia, Zhang, Jinwei, Gu, Feng

“…CRISPR-Staphylococcus aureus Cas9 (CRISPR-SaCas9) has been harnessed as an effective in vivo genome-editing tool to manipulate genomes. However, off-target…”
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In vivo SELEX for Identification of Brain-penetrating Aptamers by Cheng, Congsheng, Chen, Yong Hong, Lennox, Kim A, Behlke, Mark A, Davidson, Beverly L

“…The physiological barriers of the brain impair drug delivery for treatment of many neurological disorders. One delivery approach that has not been investigated…”
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Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching by Dawicki-McKenna, Jennine M., Felix, Alex J., Waxman, Elisa A., Cheng, Congsheng, Amado, Defne A., Ranum, Paul T., Bogush, Alexey, Dungan, Lea V., Maguire, Jean Ann, Gagne, Alyssa L., Heller, Elizabeth A., French, Deborah L., Davidson, Beverly L., Prosser, Benjamin L.

“…Alternative splicing of neuronal genes is controlled partly by the coordinated action of polypyrimidine tract binding proteins (PTBPs). While PTBP1 is…”
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Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing by Fang, Li, Monteys, Alex Mas, Dürr, Alexandra, Keiser, Megan, Cheng, Congsheng, Harapanahalli, Akhil, Gonzalez-Alegre, Pedro, Davidson, Beverly L., Wang, Kai

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by CAG trinucleotide repeat expansions in exon-1 of huntingtin (HTT)…”
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Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing by Fang, Li, Monteys, Alex Mas, Dürr, Alexandra, Keiser, Megan, Cheng, Congsheng, Harapanahalli, Akhil, Gonzalez-Alegre, Pedro, Davidson, Beverly L., Wang, Kai

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Potent inhibition of human influenza H5N1 virus by oligonucleotides derived by SELEX by Cheng, Congsheng, Dong, Jie, Yao, Lihong, Chen, Aijun, Jia, Runqing, Huan, Lifang, Guo, Jianqiang, Shu, Yuelong, Zhang, Zhiqing

“…New therapeutics are urgently needed for the treatment of pandemic influenza caused by H5N1 influenza virus mutants. Aptamer was a promising candidate for…”
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Inhibitory effect of small interfering RNA specific for a novel candidate target in PB1 gene of influenza A virus by Cheng, Congsheng, Yao, Lihong, Chen, Aijun, Jia, Runqing, Huan, Lifang, Guo, Jianqiang, Bo, Hong, Shu, Yuelong, Zhang, Zhiqing

“…Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of…”
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The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities by Cheng, Congsheng, Spengler, Ryan M, Keiser, Megan S, Monteys, Alejandro Mas, Rieders, Julianne M, Ramachandran, Shyam, Davidson, Beverly L

“…Abstract Polyglutamine (polyQ) repeat diseases are a class of neurodegenerative disorders caused by CAG-repeat expansion. There are diverse cellular mechanisms…”
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Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP by Spengler, Ryan M, Zhang, Xiaoming, Cheng, Congsheng, McLendon, Jared M, Skeie, Jessica M, Johnson, Frances L, Davidson, Beverly L, Boudreau, Ryan L

“…MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago)…”
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Efficient Human Genome Editing Using SaCas9 Ribonucleoprotein Complexes by Wang, Yufei, Wang, Bang, Xie, Haihua, Ren, Qianwen, Liu, Xiexie, Li, Fanfan, Lv, Xiujuan, He, Xiubin, Cheng, Congsheng, Deng, Ruzhi, Li, Jin, Zhao, Junzhao, Song, Zongming, Gu, Feng

“…Genome editing using RNA‐guided nucleases in their ribonucleoprotein (RNP) form represents a promising strategy for gene modification and therapy because they…”
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Erratum: Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing by Fang, Li, Monteys, Alex Mas, Dürr, Alexandra, Keiser, Megan, Cheng, Congsheng, Harapanahalli, Akhil, Gonzalez-Alegre, Pedro, Davidson, Beverly L, Wang, Kai

“…[This corrects the article DOI: 10.1016/j.xhgg.2022.100146.]…”
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Abstract 17984: No Longer Silent: A Synonymous Coding SNP Modifying a Novel MicroRNA-24: SCN5A Interaction Associates With Non-Arrhythmic Death in Heart Failure by Boudreau, Ryan L, Spengler, Ryan M, Skeie, Jessica M, Zhang, Xiaoming, Cheng, Congsheng, Yoon, Jin-Young, Gutmann, Rebecca A, Bloom, Heather L, Dudley, Samuel C, Ellinor, Patrick T, Shalaby, Alaa A, Weiss, Raul, Johnson, Frances L, Davidson, Beverly L, London, Barry

“…Mutations that disrupt the coding sequence of Nav1.5, the cardiac Na+ channel encoded by SCN5A, cause inherited arrhythmias and cardiomyopathy. Changes in…”
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Construction and delivery of gene therapy vector containing soluble TNFα receptor-IgGFc fusion gene for the treatment of allergic rhinitis by He, Jie, Wang, Tong, Yao, Lihong, Chen, Aijun, Zhou, Bing, Yu, Hong, Jia, Runqing, Cheng, Congsheng, Huan, Lifang, Zhang, Zhiqing

“…Tumor necrosis factor α plays primary role in the pathogenesis of inflammatory diseases. TNFα is essential for antigen-specific IgE production and for the…”
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Construction and delivery of gene therapy vector containing soluble TNFalpha receptor-IgGFc fusion gene for the treatment of allergic rhinitis by He, Jie, Wang, Tong, Yao, Lihong, Chen, Aijun, Zhou, Bing, Yu, Hong, Jia, Runqing, Cheng, Congsheng, Huan, Lifang, Zhang, Zhiqing

“…Tumor necrosis factor alpha plays primary role in the pathogenesis of inflammatory diseases. TNFalpha is essential for antigen-specific IgE production and for…”
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