Search Results - "Cheng, Colin W. H"

An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration by Dabouz, Rabah, Cheng, Colin W. H, Abram, Pénélope, Omri, Samy, Cagnone, Gael, Sawmy, Khushnouma Virah, Joyal, Jean-Sébastien, Desjarlais, Michel, Olson, David, Weil, Alexander G, Lubell, William, Rivera, José Carlos, Chemtob, Sylvain

“…Background Inflammation and particularly interleukin-1[beta] (IL-1[beta]), a pro-inflammatory cytokine highly secreted by activated immune cells during early…”
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Interleukin-1 Receptor Modulation Using β-Substituted α-Amino-γ-Lactam Peptides From Solid-Phase Synthesis and Diversification by Geranurimi, Azade, Cheng, Colin W H, Quiniou, Christiane, Côté, France, Hou, Xin, Lahaie, Isabelle, Boudreault, Amarilys, Chemtob, Sylvain, Lubell, William D

“…As a key cytokine mediator of inflammation, interleukin-1β (IL-1β) binds to the IL-1 receptor (IL-1R) and activates various downstream signaling mediators,…”
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Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands by Geranurimi, Azade, Cheng, Colin W H, Quiniou, Christiane, Zhu, Tang, Hou, Xin, Rivera, José Carlos, St-Cyr, Daniel J, Beauregard, Kim, Bernard-Gauthier, Vadim, Chemtob, Sylvain, Lubell, William D

“…Interleukin-1β (IL-1β) binds to the IL-1 receptor (IL-1R) and is a key cytokine mediator of inflammasome activation. IL-1β signaling leads to parturition in…”
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Interleukin-1 Receptor Modulators: Drawing Links between Structures, Biased Signaling, and in vivo Efficacy in Models of Preterm Birth and Retinopathy of Prematurity by Cheng, Colin W. H

“…Introduction: Preterm birth (PTB) and subsequently, retinopathy of prematurity (ROP), are two neonatal pathologies associated with a dysregulated inflammatory…”
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