Search Results - "Cheng, Christine C"

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice by Holland, William L., Adams, Andrew C., Brozinick, Joseph T., Bui, Hai H., Miyauchi, Yukiko, Kusminski, Christine M., Bauer, Steven M., Wade, Mark, Singhal, Esha, Cheng, Christine C., Volk, Katherine, Kuo, Ming-Shang, Gordillo, Ruth, Kharitonenkov, Alexei, Scherer, Philipp E.

“…FGF21, a member of the fibroblast growth factor (FGF) superfamily, has recently emerged as a regulator of metabolism and energy utilization. However, the exact…”
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FGF21 requires βklotho to act in vivo by Adams, Andrew C, Cheng, Christine C, Coskun, Tamer, Kharitonenkov, Alexei

“…FGF21 has gradually become a focal point in metabolic research given its intriguing and complex biology and relevance to drug discovery. Despite the large…”
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Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1 by Samms, Ricardo J., Smith, Dennis P., Cheng, Christine C., Antonellis, Patrick P., Perfield, James W., Kharitonenkov, Alexei, Gimeno, Ruth E., Adams, Andrew C.

“…A primary target of the pleiotropic metabolic hormone FGF21 is adipose tissue, where it initiates a gene expression program to enhance energy expenditure, an…”
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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 by Kharitonenkov, Alexei, Beals, John M, Micanovic, Radmila, Strifler, Beth A, Rathnachalam, Radhakrishnan, Wroblewski, Victor J, Li, Shun, Koester, Anja, Ford, Amy M, Coskun, Tamer, Dunbar, James D, Cheng, Christine C, Frye, Christopher C, Bumol, Thomas F, Moller, David E

“…Fibroblast growth factor 21 is a novel hormonal regulator with the potential to treat a broad variety of metabolic abnormalities, such as type 2 diabetes,…”
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Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice by Briere, Daniel A, Ruan, Xiaoping, Cheng, Christine C, Siesky, Angela M, Fitch, Thomas E, Dominguez, Carmen, Sanfeliciano, Sonia Gutierrez, Montero, Carlos, Suen, Chen S, Xu, Yanping, Coskun, Tamer, Michael, M Dodson

“…Activation of TGR5 via bile acids or bile acid analogs leads to the release of glucagon-like peptide-1 (GLP-1) from intestine, increases energy expenditure in…”
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FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans by Samms, Ricardo J, Lewis, Jo E, Norton, Luke, Stephens, Francis B, Gaffney, Christopher J, Butterfield, Tony, Smith, Dennis P, Cheng, Christine C, Perfield, James W, Adams, Andrew C, Ebling, Francis J P, Tsintzas, Kostas

“…Abstract Context Fibroblast growth factor 21 (FGF21) secretion has been shown to respond directly to carbohydrate consumption, with glucose, fructose, and…”
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The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue by Adams, Andrew C, Yang, Chaofeng, Coskun, Tamer, Cheng, Christine C, Gimeno, Ruth E, Luo, Yongde, Kharitonenkov, Alexei

“…Abstract FGF21 is a multifunctional metabolic regulator. The co-factor βKlotho (KLB) allows FGF21 to signal via FGF receptors. Given the widespread nature of…”
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Adipose tissue contribution to plasma fibroblast growth factor 21 and fibroblast activation protein in obesity by van Baak, Marleen A., Vink, Roel G., Roumans, Nadia J. T., Cheng, Christine C., Adams, Andrew C., Mariman, Edwin C. M.

“…Fibroblast growth factor 21 (FGF21) is an important regulator of energy metabolism. FGF21 is inactivated by fibroblast activation protein (FAP). We…”
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The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand by Burris, Thomas P, Montrose, Chahrzad, Houck, Keith A, Osborne, Harold E, Bocchinfuso, Wayne P, Yaden, Benjamin C, Cheng, Christine C, Zink, Richard W, Barr, Robert J, Hepler, Christoper D, Krishnan, Venkatesh, Bullock, Heather A, Burris, Lorri L, Galvin, Rachelle J, Bramlett, Kelli, Stayrook, Keith R

“…Guggulsterone (GS) is the active substance in guggulipid, an extract of the guggul tree, Commiphora mukul, used to treat a variety of disorders in humans,…”
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Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity by Samms, Ricardo J, Cheng, Christine C, Kharitonenkov, Alexei, Gimeno, Ruth E, Adams, Andrew C

“…The endocrine hormone fibroblast growth factor 21 (FGF21) is induced in the adaptive response to nutrient deprivation, where it serves to regulate the…”
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Serum FGF21 levels are associated with brown adipose tissue activity in humans by Hanssen, Mark J.W., Broeders, Evie, Samms, Ricardo J., Vosselman, Maarten J., van der Lans, Anouk A.J.J., Cheng, Christine C., Adams, Andrew C., van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick

“…The obesity pandemic has spurred a need for novel therapies to prevent and treat metabolic complications. The recent rediscovery of brown adipose tissue (BAT)…”
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FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes by Samms, Ricardo J, Cheng, Christine C, Fourcaudot, Marcel, Heikkinen, Sami, Khattab, Ahmed, Adams, John, Cersosimo, Eugenio, Triplitt, Curtis, Puckett, Curtis, Tsintzas, Kostas, Adams, Andrew C, Abdul-Ghani, Muhammad A, DeFronzo, Ralph A, Norton, Luke

“…Fibroblast growth factor 21 (FGF21) is increased acutely by carbohydrate ingestion and is elevated in patients with type 2 diabetes (T2D). However, the…”
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Eccentric exercise increases circulating fibroblast activation protein α but not bioactive fibroblast growth factor 21 in healthy humans by Parmar, Biraj, Lewis, Jo E., Samms, Ricardo J., Ebling, Francis J. P., Cheng, Christine C., Adams, Andrew C., Mallinson, Joanne, Cooper, Scott, Taylor, Tariq, Ghasemi, Reza, Stephens, Francis B., Tsintzas, Kostas

“…New Findings What is the central question of this study? The role of FGF21 as an exercise‐induced myokine remains controversial. The aim of this study was to…”
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Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma by Lam, Ching Yan, Yip, Chi Wai, Poon, Terence C W, Cheng, Christine K C, Ng, Eddy W Y, Wong, Nicholas C L, Cheung, Phyllis F Y, Lai, Paul B S, Ng, Irene O L, Fan, Sheung Tat, Cheung, Siu Tim

“…Granulin-epithelin precursor (GEP) has previously been reported to control cancer growth, invasion, chemo-resistance, and served as novel therapeutic target…”
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GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice by Samms, Ricardo J, Christe, Michael E, Collins, Kyla A, Pirro, Valentina, Droz, Brian A, Holland, Adrienne K, Friedrich, Jessica L, Wojnicki, Samantha, Konkol, Debra L, Cosgrove, Richard, Conceição Furber, Ellen Ps, Ruan, Xiaoping, O'Farrell, Libbey S, Long, Annie M, Dogra, Mridula, Willency, Jill A, Lin, Yanzhu, Ding, Liyun, Cheng, Christine C, Cabrera, Over, Briere, Daniel A, Alsina-Fernandez, Jorge, Gimeno, Ruth E, Moyers, Julie S, Coskun, Tamer, Coghlan, Matthew P, Sloop, Kyle W, Roell, William C

“…Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor agonist, delivered superior glycemic control and weight loss compared to GLP-1 receptor (GLP-1R) agonism…”
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Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones by Adams, Andrew C., PhD, Coskun, Tamer, MD, Cheng, Christine C, O′Farrell, Libbey S, DuBois, Susan L, Kharitonenkov, Alexei, PhD

“…Abstract Fibroblast growth factor 21 is an emerging metabolic regulator that was recently proposed to be a fed-state inducible factor in adipose tissue. As…”
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Granulin-Epithelin Precursor and ATP-Dependent Binding Cassette (ABC)B5 Regulate Liver Cancer Cell Chemoresistance by Cheung, Siu Tim, Cheung, Phyllis F.Y, Cheng, Christine K.C, Wong, Nicholas C.L, Fan, Sheung Tat

“…Background & Aims Chemotherapy is used to treat unresectable liver cancer with marginal efficacy; this might result from hepatic cancer cells with stem cell…”
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Granulin-epithelin precursor interacts with heparan sulfate on liver cancer cells by Yip, Chi Wai, Cheung, Phyllis F Y, Leung, Idy C Y, Wong, Nicholas C L, Cheng, Christine K C, Fan, Sheung Tat, Cheung, Siu Tim

“…Granulin-epithelin precursor (GEP) is a pluripotent secretory growth factor which promotes cancer progression in a number of human cancers. However, how cancer…”
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Overexpression of [beta]-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity by Samms, Ricardo J, Cheng, Christine C, Kharitonenkov, Alexei, Gimeno, Ruth E, Adams, Andrew C

“…The endocrine hormone fibroblast growth factor 21 (FGF21) is induced in the adaptive response to nutrient deprivation, where it serves to regulate the…”
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FGF21 Requires [beta]klotho to Act In Vivo by Adams, Andrew C, Cheng, Christine C, Coskun, Tamer, Kharitonenkov, Alexei

“…FGF21 has gradually become a focal point in metabolic research given its intriguing and complex biology and relevance to drug discovery. Despite the large…”
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