Search Results - "Cheng, Chak‐Kwong"

Endothelial dysfunction after androgen deprivation therapy and the possible underlying mechanisms by Teoh, Jeremy Yuen‐Chun, Tian, Xiao‐Yu, Wong, Christine Yim‐Ping, Lau, Chi‐Wai, Cheng, Chak‐Kwong, Tang, Victor Wai‐Lun, Chan, Ronald Cheong‐Kin, Huang, Yu, Ng, Chi‐Fai

“…Introduction Androgen deprivation therapy (ADT) is a key treatment modality in the management of prostate cancer (PCa), especially for patients with metastatic…”
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Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice by Cheng, Chak-Kwong, Shang, Wenbin, Liu, Jian, Cheang, Wai-San, Wang, Yu, Xiang, Li, Lau, Chi-Wai, Luo, Jiang-Yun, Ng, Chi-Fai, Huang, Yu, Wang, Li

“…Hyperglycemia in diabetes mellitus impairs endothelial function and disrupts microRNA (miRNA) profiles in vasculature, increasing the risk of…”
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Recent Advances in Managing Atherosclerosis via Nanomedicine by Chan, Cecilia Ka Wing, Zhang, Lei, Cheng, Chak Kwong, Yang, Hongrong, Huang, Yu, Tian, Xiao Yu, Choi, Chung Hang Jonathan

“…Atherosclerosis, driven by chronic inflammation of the arteries and lipid accumulation on the blood vessel wall, underpins many cardiovascular diseases with…”
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Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives by Wang, Yu, Jin, Mingyue, Cheng, Chak Kwong, Li, Qiang

“…Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide. Currently, there are…”
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Role of gasdermin D in inflammatory diseases: from mechanism to therapeutics by Cheng, Chak Kwong, Yi, Min, Wang, Li, Huang, Yu

“…Inflammatory diseases compromise a clinically common and diverse group of conditions, causing detrimental effects on body functions. Gasdermins (GSDM) are…”
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Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation by Cheng, Chak Kwong, Ding, Huanyu, Jiang, Minchun, Yin, Huiyong, Gollasch, Maik, Huang, Yu

“…Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding the vasculature, exhibiting the phenotypes of white, beige and brown…”
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Oral microbiome: a doubtful predictor but potential target of cardiovascular diseases by Cheng, Chak Kwong, Huang, Yu

“…Our oral cavity houses various types of microbes including bacteria, protozoa, fungi and viruses, harboring over 700 bacterial species. Oral dysbiosis refers…”
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The gut-cardiovascular connection: new era for cardiovascular therapy by Cheng, Chak Kwong, Huang, Yu

“…Our gut microbiome is constituted by trillions of microorganisms including bacteria, archaea and eukaryotic microbes. Nowadays, gut microbiome has been…”
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Endogenous and microbial biomarkers for periodontitis and type 2 diabetes mellitus by Li, Songjun, Li, Hongwen, Kong, Haiying, Wu, Shang Ying, Cheng, Chak Kwong, Xu, Jian

“…It has been well documented that there is a two-way relationship between diabetes mellitus and periodontitis. Diabetes mellitus represents an established risk…”
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Activation of Nrf2 inhibits atherosclerosis in ApoE−/− mice through suppressing endothelial cell inflammation and lipid peroxidation by He, Lei, Chen, Qinghua, Wang, Li, Pu, Yujie, Huang, Juan, Cheng, Chak Kwong, Luo, Jiang-Yun, Kang, Lijing, Lin, Xiao, Xiang, Li, Fang, Liang, He, Ben, Xia, Yin, Lui, Kathy O., Pan, Yong, Liu, Jie, Zhang, Cheng-Lin, Huang, Yu

“…Nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, is critically involved in the regulation of oxidative stress and inflammation. However,…”
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Aged Gut Microbiome Induces Metabolic Impairment and Hallmarks of Vascular and Intestinal Aging in Young Mice by Cheng, Chak-Kwong, Ye, Lianwei, Zuo, Yuanyuan, Wang, Yaling, Wang, Li, Li, Fuyong, Chen, Sheng, Huang, Yu

“…Aging, an independent risk factor for cardiometabolic diseases, refers to a progressive deterioration in physiological function, characterized by 12…”
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SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis by Cheng, Chak Kwong, Lin, Xiao, Pu, Yujie, Tse, Joyce Ka Yu, Wang, Yu, Zhang, Cheng-Lin, Cao, Xiaoyun, Lau, Chi Wai, Huang, Juan, He, Lei, Luo, Jiang-Yun, Shih, Yu-Tsung, Wan, Song, Ng, Chi Fai, Wang, Li, Ma, Ronald Ching Wan, Chiu, Jeng-Jiann, Chan, Ting Fung, Yu Tian, Xiao, Huang, Yu

“…Hyperlipidemia-associated cytokines and disturbed flow upregulate SOX4 expression in ECs, where SOX4 promotes EndoMT and atherogenesis. Metformin…”
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A high methionine and low folate diet alters glucose homeostasis and gut microbiome by Cheng, Chak Kwong, Wang, Chenguang, Shang, Wenbin, Lau, Chi Wai, Luo, Jiang-Yun, Wang, Li, Huang, Yu

“…Hyperhomocysteinemia (HHcy) is considered as a risk factor for several complications, including cardiovascular and neurological disorders. A high methionine…”
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Vascular endothelium: The interface for multiplex signal transduction by Cheng, Chak Kwong, Huang, Yu

“…As the innermost monolayer of the vasculature, endothelial cells (ECs) serve as the interface for multiplex signal transduction. Directly exposed to…”
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Targeting endothelial dysfunction and inflammation by Wang, Li, Cheng, Chak Kwong, Yi, Min, Lui, Kathy O., Huang, Yu

“…Vascular endothelium maintains vascular homeostasis through liberating a spectrum of vasoactive molecules, both protective and harmful regulators of vascular…”
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1150-P: A Hyperhomocysteinemia-Inducing Diet Alters Gut Microbiome and Glucose Homeostasis by CHENG, CHAK KWONG, WANG, CHENGUANG, HUANG, YU

“…Hyperhomocysteinemia (HHcy) is a risk factor for higher mortality in type 2 diabetic patients. A high methionine low folate (HMLF) diet chronically induces…”
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Fecal microbiota transfer from aged mice promotes hallmarks of vascular ageing and metabolic impairments in young mice by Cheng, Chak Kwong, Zuo, Yuanyuan, Gao, Jun, Huang, Yu

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Pharmacological basis and new insights of resveratrol action in the cardiovascular system by Cheng, Chak Kwong, Luo, Jiang‐Yun, Lau, Chi Wai, Chen, Zhen‐Yu, Tian, Xiao Yu, Huang, Yu

“…Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports…”
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Fecal Microbiota Transfer from Young Mice Reverts Vascular Aging Hallmarks and Metabolic Impairments in Aged Mice by Cheng, Chak Kwong, Gao, Jun, Kang, Lijing, Huang, Yu

“…As a major risk factor for cardiometabolic diseases, aging refers to a gradual decline in physiological function, characterized with 12 conspicuous hallmarks,…”
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Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ by Cheang, Wai San, Wong, Wing Tak, Wang, Li, Cheng, Chak Kwong, Lau, Chi Wai, Ma, Ronald Chin Wan, Xu, Aimin, Wang, Nanping, Huang, Yu, Tian, Xiao Yu

“…[Display omitted] Sirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory responses, and retards cellular senescence in endothelial cells…”
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