Search Results - "Cheng, Alan G."

β-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development by Ebeid, Michael, Kishimoto, Ippei, Roy, Pooja, Zaidi, Mohd Ali Abbas, Cheng, Alan G., Huh, Sung-Ho

“…The mammalian cochlea is composed of sensory hair cells as well as multiple different types of non-sensory supporting cells. Pillar cells are one type of…”
Get full text

Sensory hair cell development and regeneration: similarities and differences by Atkinson, Patrick J, Huarcaya Najarro, Elvis, Sayyid, Zahra N, Cheng, Alan G

“…Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are crucial for hearing and balance. In adult mammals, auditory hair cells…”
Get full text

Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity by Alharazneh, Abdelrahman, Luk, Lauren, Huth, Markus, Monfared, Ashkan, Steyger, Peter S, Cheng, Alan G, Ricci, Anthony J

“…Aminoglycosides (AG) are commonly prescribed antibiotics with potent bactericidal activities. One main side effect is permanent sensorineural hearing loss,…”
Get full text

Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo by Cox, Brandon C, Chai, Renjie, Lenoir, Anne, Liu, Zhiyong, Zhang, LingLi, Nguyen, Duc-Huy, Chalasani, Kavita, Steigelman, Katherine A, Fang, Jie, Rubel, Edwin W, Cheng, Alan G, Zuo, Jian

“…Loss of cochlear hair cells in mammals is currently believed to be permanent, resulting in hearing impairment that affects more than 10% of the population…”
Get full text

Lineage-tracing and translatomic analysis of damage-inducible mitotic cochlear progenitors identifies candidate genes regulating regeneration by Udagawa, Tomokatsu, Atkinson, Patrick J, Milon, Beatrice, Abitbol, Julia M, Song, Yang, Sperber, Michal, Huarcaya Najarro, Elvis, Scheibinger, Mirko, Elkon, Ran, Hertzano, Ronna, Cheng, Alan G

“…Cochlear supporting cells (SCs) are glia-like cells critical for hearing function. In the neonatal cochlea, the greater epithelial ridge (GER) is a mitotically…”
Get full text

Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System by Sayyid, Zahra N, Wang, Tian, Chen, Leon, Jones, Sherri M, Cheng, Alan G

“…Utricular hair cells (HCs) are mechanoreceptors required for vestibular function. After damage, regeneration of mammalian utricular HCs is limited and…”
Get full text

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea by Chai, Renjie, Kuo, Bryan, Wang, Tian, Liaw, Eric J, Xia, Anping, Jan, Taha A, Liu, Zhiyong, Taketo, Makoto M, Oghalai, John S, Nusse, Roeland, Zuo, Jian, Cheng, Alan G

“…Inner ear hair cells are specialized sensory cells essential for auditory function. Previous studies have shown that the sensory epithelium is postmitotic, but…”
Get full text

Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle by Wang, Tian, Chai, Renjie, Kim, Grace S., Pham, Nicole, Jansson, Lina, Nguyen, Duc-Huy, Kuo, Bryan, May, Lindsey A., Zuo, Jian, Cunningham, Lisa L., Cheng, Alan G.

“…Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle requires mechanosensory hair cells (HCs) to detect linear…”
Get full text

Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle by Wang, Tian, Yang, Tian, Kedaigle, Amanda, Pregernig, Gabriela, McCarthy, Ryan, Holmes, Ben, Wu, Xudong, Becker, Lars, Pan, Ning, So, Kathy, Chen, Leon, He, Jun, Mahmoudi, Ahmad, Negi, Soumya, Kowalczyk, Monika, Gibson, Tyler, Druckenbrod, Noah, Cheng, Alan G., Burns, Joseph

“…Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as…”
Get full text

Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics by Jan, Taha A., Eltawil, Yasmin, Ling, Angela H., Chen, Leon, Ellwanger, Daniel C., Heller, Stefan, Cheng, Alan G.

“…The utricle is a vestibular sensory organ that requires mechanosensitive hair cells to detect linear acceleration. In neonatal mice, new hair cells are derived…”
Get full text

Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells by Wang, Tian, Niwa, Mamiko, Sayyid, Zahra N, Hosseini, Davood K, Pham, Nicole, Jones, Sherri M, Ricci, Anthony J, Cheng, Alan G

“…Sensory hair cells are mechanoreceptors required for hearing and balance functions. From embryonic development, hair cells acquire apical stereociliary bundles…”
Get full text

Loss of Pax3 causes reduction of melanocytes in the developing mouse cochlea by Udagawa, Tomokatsu, Takahashi, Erisa, Tatsumi, Norifumi, Mutai, Hideki, Saijo, Hiroki, Kondo, Yuko, Atkinson, Patrick J., Matsunaga, Tatsuo, Yoshikawa, Mamoru, Kojima, Hiromi, Okabe, Masataka, Cheng, Alan G.

“…Cochlear melanocytes are intermediate cells in the stria vascularis that generate endocochlear potentials required for auditory function. Human PAX3 mutations…”
Get full text

Towards the Prevention of Aminoglycoside-Related Hearing Loss by O'Sullivan, Mary E, Perez, Adela, Lin, Randy, Sajjadi, Autefeh, Ricci, Anthony J, Cheng, Alan G

“…Aminoglycosides are potent antibiotics deployed worldwide despite their known side-effect of sensorineural hearing loss. The main etiology of this sensory…”
Get full text

Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death by Vu, Andrew A, Nadaraja, Garani S, Huth, Markus E, Luk, Lauren, Kim, John, Chai, Renjie, Ricci, Anthony J, Cheng, Alan G

“…Sound perception requires functional hair cell mechanotransduction (MET) machinery, including the MET channels and tip-link proteins. Prior work showed that…”
Get full text

Making sense of Wnt signaling-linking hair cell regeneration to development by Jansson, Lina, Kim, Grace S, Cheng, Alan G

“…Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to…”
Get full text

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs by Wang, Tian, Ling, Angela H., Billings, Sara E., Hosseini, Davood K., Vaisbuch, Yona, Kim, Grace S., Atkinson, Patrick J., Sayyid, Zahra N., Aaron, Ksenia A., Wagh, Dhananjay, Pham, Nicole, Scheibinger, Mirko, Zhou, Ruiqi, Ishiyama, Akira, Moore, Lindsay S., Maria, Peter Santa, Blevins, Nikolas H., Jackler, Robert K., Alyono, Jennifer C., Kveton, John, Navaratnam, Dhasakumar, Heller, Stefan, Lopez, Ivan A., Grillet, Nicolas, Jan, Taha A., Cheng, Alan G.

“…Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle…”
Get full text

Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature by O'Sullivan, Mary E, Poitevin, Frédéric, Sierra, Raymond G, Gati, Cornelius, Dao, E Han, Rao, Yashas, Aksit, Fulya, Ciftci, Halilibrahim, Corsepius, Nicholas, Greenhouse, Robert, Hayes, Brandon, Hunter, Mark S, Liang, Mengling, McGurk, Alex, Mbgam, Paul, Obrinsky, Trevor, Pardo-Avila, Fátima, Seaberg, Matthew H, Cheng, Alan G, Ricci, Anthony J, DeMirci, Hasan

“…Abstract The bacterial 30S ribosomal subunit is a primary antibiotic target. Despite decades of discovery, the mechanisms by which antibiotic binding induces…”
Get full text

Hair Cell Regeneration: From Animals to Humans by Choi, Sung-Won, Abitbol, Julia, Cheng, Alan

“…Cochlear hair cells are critical in converting sound into electrical signals that are relayed via the spiral ganglion neurons to the central auditory pathway…”
Get full text

Editorial: Epidemiology and Genetics of Vestibular Disorders by Lopez-Escamez, Jose A., Cheng, Alan G., Grill, Eva, Liu, Tien-Chen

Get full text

Assessment of drug permeability through an ex vivo porcine round window membrane model by Moatti, Adele, Silkstone, Dylan, Martin, Taylor, Abbey, Keith, Hutson, Kendall A, Fitzpatrick, Douglas C, Zdanski, Carlton J, Cheng, Alan G, Ligler, Frances S, Greenbaum, Alon

“…Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small…”
Get full text