Search Results - "Cheng, Adam Z"

APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1 by Ikeda, Terumasa, Shimizu, Ryo, Nasser, Hesham, Carpenter, Michael A, Cheng, Adam Z, Brown, William L, Sauter, Daniel, Harris, Reuben S

“…HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4 T lymphocytes and macrophages. Previous studies have demonstrated that the…”
Get full text

Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity by Hayward, Joshua A, Tachedjian, Mary, Cui, Jie, Cheng, Adam Z, Johnson, Adam, Baker, Michelle L, Harris, Reuben S, Wang, Lin-Fa, Tachedjian, Gilda

“…Bats have attracted attention in recent years as important reservoirs of viruses deadly to humans and other mammals. These infections are typically…”
Get full text

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism by Fanunza, Elisa, Cheng, Adam Z, Auerbach, Ashley A, Stefanovska, Bojana, Moraes, Sofia N, Lokensgard, James R, Biolatti, Matteo, Dell'Oste, Valentina, Bierle, Craig J, Bresnahan, Wade A, Harris, Reuben S

“…The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the innate antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and…”
Get full text

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits by Cheng, Adam Z, Moraes, Sofia N, Attarian, Claire, Yockteng-Melgar, Jaime, Jarvis, Matthew C, Biolatti, Matteo, Galitska, Ganna, Dell'Oste, Valentina, Frappier, Lori, Bierle, Craig J, Rice, Stephen A, Harris, Reuben S

“…An integral part of the antiviral innate immune response is the APOBEC3 family of single-stranded DNA cytosine deaminases, which inhibits virus replication…”
Get full text

APOBECs and Herpesviruses by Cheng, Adam Z, Moraes, Sofia N, Shaban, Nadine M, Fanunza, Elisa, Bierle, Craig J, Southern, Peter J, Bresnahan, Wade A, Rice, Stephen A, Harris, Reuben S

“…The APOBEC family of DNA cytosine deaminases provides a broad and overlapping defense against viral infections. Successful viral pathogens, by definition, have…”
Get full text

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases by Moraes, Sofia N, Becker, Jordan T, Moghadasi, Seyed Arad, Shaban, Nadine M, Auerbach, Ashley A, Cheng, Adam Z, Harris, Reuben S

“…Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the…”
Get full text

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease by Ebrahimi, Diako, Richards, Christopher M., Carpenter, Michael A., Wang, Jiayi, Ikeda, Terumasa, Becker, Jordan T., Cheng, Adam Z., McCann, Jennifer L., Shaban, Nadine M., Salamango, Daniel J., Starrett, Gabriel J., Lingappa, Jairam R., Yong, Jeongsik, Brown, William L., Harris, Reuben S.

“…Human APOBEC3H (A3H) is a single-stranded DNA cytosine deaminase that inhibits HIV-1. Seven haplotypes (I–VII) and four splice variants (SV154/182/183/200)…”
Get full text

G1/S Cell Cycle Induction by Epstein-Barr Virus BORF2 Is Mediated by P53 and APOBEC3B by Yockteng-Melgar, Jaime, Shire, Kathy, Cheng, Adam Z., Malik-Soni, Natasha, Harris, Reuben S., Frappier, Lori

“…Herpesvirus lytic infection causes cells to arrest at the G1/S phase of the cell cycle by poorly defined mechanisms. In a prior study using fluorescent…”
Get full text

G 1 /S Cell Cycle Induction by Epstein-Barr Virus BORF2 Is Mediated by P53 and APOBEC3B by Yockteng-Melgar, Jaime, Shire, Kathy, Cheng, Adam Z, Malik-Soni, Natasha, Harris, Reuben S, Frappier, Lori

“…Herpesvirus lytic infection causes cells to arrest at the G /S phase of the cell cycle by poorly defined mechanisms. In a prior study using fluorescent…”
Get full text

Epstein–Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity by Cheng, Adam Z., Yockteng-Melgar, Jaime, Jarvis, Matthew C., Malik-Soni, Natasha, Borozan, Ivan, Carpenter, Michael A., McCann, Jennifer L., Ebrahimi, Diako, Shaban, Nadine M., Marcon, Edyta, Greenblatt, Jack, Brown, William L., Frappier, Lori, Harris, Reuben S.

“…The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides…”
Get full text

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction by Salamango, Daniel J., Becker, Jordan T., McCann, Jennifer L., Cheng, Adam Z., Demir, Özlem, Amaro, Rommie E., Brown, William L., Shaban, Nadine M., Harris, Reuben S.

“…APOBEC enzymes are DNA cytosine deaminases that normally serve as virus restriction factors, but several members, including APOBEC3H, also contribute to cancer…”
Get full text

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition by Shaban, Nadine M, Yan, Rui, Shi, Ke, Moraes, Sofia N, Cheng, Adam Z, Carpenter, Michael A, McLellan, Jason S, Yu, Zhiheng, Harris, Reuben S

“…Viruses use a plethora of mechanisms to evade immune responses. A recent example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the…”
Get full text

Counteraction of APOBEC3 Proteins by Herpesvirus Ribonucleotide Reductases by Cheng, Adam Z

“…The APOBEC3 family of DNA cytosine deaminases plays an important role in antiviral innate immunity. In this thesis, we describe the novel function of APOBEC3B…”
Get full text