Search Results - "Chene, Laurent"

630 EO2401, a new peptide immunotherapy against cancer, in combination with nivolumab, induces a strong and durable immune response in patients from the EOADR1–19/SPENCER study by Aubergeon, Lucie, Baudin, Eric, Berruti, Alfredo, Grisanti, Salvatore, Oordt, CWillemien Menke-vander Houven van, Haak, Harm, Fassnacht, Martin, Capdevila, Jaume, Subbiah, Vivek, Jimenez, Camilo, Fouchardière, Christelle de la, Granberg, Dan, Kroiss, Matthias, Daugaard, Gedske, Toussaint, Hélène, Magalhaes, Joao Gamelas, Martinez, Jennifer, Belyn, Camille, Kervevan, Jerome, Ventujol, Chloé, Bonny, Christophe, Paillarse, Jean-Michel, Chene, Laurent

“…BackgroundEOADR1–19/SPENCER study is a phase 1/2 trial of EO2401, evaluating the combination of EO2401 with nivolumab, for the treatment of patients with…”
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1423 Novel immunotherapy based on commensal-derived peptides to drive an effective CD8 T Cell response against selected tumor-associated antigens (TAAs) by Talpin, Alice, Kervevan, Jerome, Aubergeon, Lucie, Maia, Ana, Blanc, Tifanny Mersceman, Bachrouche, Diana, Ventujol, Chloé, Bernard, Léa, Manteau, Amandine, Gouttefangeas, Cecile, Villasboas, Jose, Pinto, Antonello, Bosch, Francesc, García-Sanz, Ramon, Garcia, Carlos Grande, Smith, Stephen D, Arcaini, Luca, Merryman, Reid, Friedberg, Jonathan W, Ansell, Stephen, Armand, Philippe, Zinzani, Pier, Bonny, Christophe, Chene, Laurent, Magalhaes, Joao Gamelas

“…BackgroundEfficacy demonstration of a unique peptide-based immunotherapy as potent approach for cancer treatment. This strategy relies on the activation of…”
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Quantification of expression of netrins, slits and their receptors in human prostate tumors by Latil, Alain, Chêne, Laurent, Cochant‐Priollet, Béatrix, Mangin, Philippe, Fournier, Georges, Berthon, Philippe, Cussenot, Olivier

“…Recently, DCC (Deleted in Colorectal Cancer) protein has been forwarded as a receptor for netrin. The Netrin/DCC complex is critical for axon guidance and cell…”
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Gene expression profiling in clinically localized prostate cancer: A four-gene expression model predicts clinical behavior by LATIL, Alain, BIECHE, Ivan, CHENE, Laurent, LAURENDEAU, Ingrid, BERTHON, Philippe, CUSSENOT, Olivier, VIDAUD, Michel

“…New diagnostic and prognostic molecular markers are required for prostate cancer, one of the most common male malignancies in Western countries. Gene…”
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Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease by Oñate, Florian Plaza, Chamignon, Célia, Burz, Sebastian D, Lapaque, Nicolas, Monnoye, Magali, Philippe, Catherine, Bredel, Maxime, Chêne, Laurent, Farin, William, Paillarse, Jean-Michel, Boursier, Jérome, Ratziu, Vlad, Mousset, Pierre-Yves, Doré, Joël, Gérard, Philippe, Blottière, Hervé M

“…Non-alcoholic fatty liver disease (NAFLD) affects about 20-40% of the adult population in high-income countries and is now a leading indication for liver…”
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Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene by Chêne, Laurent, Giroud, Christiane, Desgrandchamps, François, Boccon‐Gibod, Laurent, Cussenot, Olivier, Berthon, Philippe, Latil, Alain

“…Loss of heterozygosity (LOH) on chromosome arm 7q31 is found in many prostate tumors. Such alterations are generally associated with inactivation of tumor…”
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New spiro-piperidines as 5-HT2B receptor antagonists by Bienaymé, Hugues, Chêne, Laurent, Grisoni, Serge, Grondin, Antonio, Kaloun, El-Bachir, Poigny, Stéphane, Rahali, Houcine, Tam, Eric

“…The synthesis of the compound 45 (IC50=1.8nM) and its analogs is reported. A functional screening highlighted a series of spiro-piperidines as 5-HT2B receptor…”
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Fecal Microbiota Transplant from Human to Mice Gives Insights into the Role of the Gut Microbiota in Non-Alcoholic Fatty Liver Disease (NAFLD) by Burz, Sebastian D, Monnoye, Magali, Philippe, Catherine, Farin, William, Ratziu, Vlad, Strozzi, Francesco, Paillarse, Jean-Michel, Chêne, Laurent, Blottière, Hervé M, Gérard, Philippe

“…Non-alcoholic fatty liver diseases (NAFLD) are associated with changes in the composition and metabolic activities of the gut microbiota. However, the causal…”
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Interleukin-7 and infection itself by human immunodeficiency virus 1 favor virus persistence in mature CD4+CD8−CD3+ thymocytes through sustained induction of Bcl-2 by Guillemard, Eric, Nugeyre, Marie-Thérèse, Chêne, Laurent, Schmitt, Nathalie, Jacquemot, Catherine, Barré-Sinoussi, Françoise, Israël, Nicole

“…The sequence of events and the mechanisms leading to the destruction of the thymus during human immunodeficiency virus (HIV) infection are still poorly…”
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Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation by Liuu, Sophie, Nepelska, Malgorzata, Pfister, Hélène, Gamelas Magalhaes, Joao, Chevalier, Gregoire, Strozzi, Francesco, Billerey, Coline, Maresca, Marc, Nicoletti, Cendrine, Di Pasquale, Eric, Pechard, Charlie, Bardouillet, Laureen, Girardin, Stephen E, Boneca, Ivo Gomperts, Doré, Joel, Blottière, Hervé M, Bonny, Christophe, Chene, Laurent, Cultrone, Antonietta

“…The gut microbiota is a considerable source of biologically active compounds that can promote intestinal homeostasis and improve immune responses. Here, we…”
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Abstract 1475: Microbiome derived peptides stimulate strong immune response against tumor associated antigens and trigger in vivo tumor regression after vaccination by Chene, Laurent, Sader, Caroline Diveu, Magalhaes, Joao, Strozzi, Francesco, Tibaldi, Lorenzo, Mendez, Celia, Baeriswyl, Simon, Laveissiere, Arnaud, Bonny, Christophe

“…Abstract Peptide-based vaccination is an immunotherapeutic approach for the treatment of cancer that aims to deliver immunogenic peptides corresponding to…”
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IL-7 Stimulates T Cell Renewal Without Increasing Viral Replication in Simian Immunodeficiency Virus-Infected Macaques by Nugeyre, Marie-Therese, Monceaux, Valerie, Beq, Stephanie, Cumont, Marie-Christine, Fang, Raphael Ho Tsong, Chene, Laurent, Morre, Michel, Barre-Sinoussi, Francoise, Hurtrel, Bruno, Israel, Nicole

“…The main failure of antiretroviral therapy is the lack of restoration of HIV-specific CD4(+) T cells. IL-7, which has been shown to be a crucial cytokine for…”
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Positive Regulation of CXCR4 Expression and Signaling by Interleukin-7 in CD4+ Mature Thymocytes Correlates with Their Capacity To Favor Human Immunodeficiency X4 Virus Replication by Schmitt, Nathalie, Chêne, Laurent, Boutolleau, David, Nugeyre, Marie-Thérèse, Guillemard, Eric, Versmisse, Pierre, Jacquemot, Catherine, Barré-Sinoussi, Françoise, Israël, Nicole

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Abstract 99: Identification of G9a inhibitors by AlphaLisa™ technology and hit confirmation using MT-Glo by Fromond, Claudia, Espanel, Xavier, Chene, Laurent, Masson, Philippe, Boubia, Benaïssa, Montalbetti, Christian, Broqua, Pierre

“…Abstract Epigenetic processes control gene expression and play a major role in cell proliferation, survival and differentiation. Dysregulation of epigenetic…”
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Abstract 2200: A rational approach for discovery of inhibitors of YAP-TEAD interaction by Fromond, Claudia, Chene, Laurent, Soude, Anne, Barth, Martine, Montalbetti, Christian, Broqua, Pierre

“…Abstract The Hippo signalling pathway plays a major role in organ growth regulation and tumorigenesis. By sensing contact inhibition, the central kinase…”
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Abstract 105: A rational approach for the discovery of inhibitors of NSD2 for the treatment of cancer by Fromond, Claudia, Espanel, Xavier, Soudé, Anne, Chene, Laurent, Masson, Philippe, Boubia, Benaïssa, Montalbetti, Christian, Broqua, Pierre

“…Abstract Multiple myeloma (MM) is a plasma cell malignancy which accounts for approximately 10% of hematologic malignancies. Despite the introduction of new…”
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Abstract 4090: Gut microbiota mimics as a source of cross-reactive tumor rejection antigens by Panneton, Vincent, Gigoux, Mathieu, Zebboudj, Abderezak, Sadek, Norah, Choi, Hyejin, Mangarin, Levi M., George, Mariam M., Kulakowski, Guillaume, Magalhaes, Joao G., Carpier, Jean-Marie, Dugat, Thibaud, Gaal, Camille, Strozzi, Francesco, Tibaldi, Lorenzo, Chene, Laurent, Wolchok, Jedd D., Balachandran, Vinod P., Merghoub, Taha

“…Abstract The crosstalk between gut microbiome and anti-tumor immunity has recently gained attention in clinical settings. The administration of antibiotics…”
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Human Immunodeficiency Virus Induces a Dual Regulation of Bcl-2, Resulting in Persistent Infection of CD4+ T- or Monocytic Cell Lines by Aillet, F, Masutani, H, Elbim, C, Raoul, H, Chêne, L, Nugeyre, M T, Paya, C, Barré-Sinoussi, F, Gougerot-Pocidalo, M A, Israël, N

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High-Level Replication of Human Immunodeficiency Virus in Thymocytes Requires NF-κB Activation through Interaction with Thymic Epithelial Cells by Chene, L, Nugeyre, M, Barre-Sinoussi, F, Israel, N

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Phase 1/2 of EO2463 immunotherapy as monotherapy and in combination with lenalidomide and/or rituximab in indolent NHL (EONHL1-20/SIDNEY) by Villasboas, Jose Caetano, Wallace, Danielle, Smith, Stephen Douglas, Grande, Carlos, Marolleau, Jean Pierre, Bosch, Francesc, Pinto, Antonio, Arcaini, Luca, Merryman, Reid, Garcia Sanz, Ramón, Zinzani, Pier Luigi, Aubergeon, Lucie, Chêne, Laurent, Fagerberg, Jan, Armand, Philippe, Friedberg, Jonathan, Ansell, Stephen

“…Background: Follicular and marginal zone B cell lymphoma (FL; MZL) demonstrate an indolent course with heterogeneous outcomes anda potential for spontaneous…”
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