Search Results - "Chen, Zude"

A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy by Chen, Zude, Yang, Xiaoshuang, Chen, Zugen, Li, Minzhao, Wang, Wei, Yang, Riwei, Wang, Zuomin, Ma, Yuxiang, Xu, Yulong, Ao, Shan, Liang, Leqi, Cai, Chao, Wang, Changning, Deng, Tuo, Gu, Di, Zhou, Hongqing, Zeng, Guohua

“…Background Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It…”
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Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer by Chen, Zude, Wang, Xiashuang, Yang, Xiaoshuang, Xu, Yulong, Yang, Yu, Wang, Hao, Li, Tao, Bai, Ping, Yuan, Gengyang, Chen, Huabiao, Yang, Jing, Fiedler, Stephanie A., Striar, Robin, Bernales, Daniela R., Koegel, Robert E., Cao, Qi, Ran, Chongzhao, Xiang, Bo, Li, Hong, Wang, Changning

“…Purpose Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by…”
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COVID-19 inhibits spermatogenesis in the testes by inducing cellular senescence by Wang, Zuomin, Ma, Yuxiang, Chen, Zude, Yang, Riwei, Liu, Qinwei, Pan, Jinyou, Wang, Jiamin, Liu, Yangzhou, Zhou, Mingda, Zhang, Yihan, Zhou, Yuhao, Yang, Shuxin, Zou, Bangyu, Lin, Jingwei, Cai, Yingxin, Jiang, Zheng, Zhou, Zhen, Zhao, Zhigang

“…COVID-19 (SARS-CoV-2) has been linked to organ damage in humans since its worldwide outbreak. It can also induce severe sperm damage, according to research…”
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Radiosynthesis of [11C]EI1 for imaging EZH2 using positron emission tomography by Wang, Hao, Lan, Yu, Bai, Ping, Chen, Zude, Luo, Shenglin, Xu, Yulong, Fiedler, Stephanie, Striar, Robin, Wang, Changning

“…Enhancer of zeste homolog 2 (EZH2) is responsible for the methylation of lysine 27 of histone H3 (H3K27) leading to transcriptional repression. Consequently,…”
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Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET) by Lan, Yu, Bai, Ping, Chen, Zude, Neelamegam, Ramesh, Placzek, Michael S., Wang, Hao, Fiedler, Stephanie A., Yang, Jing, Yuan, Gengyang, Qu, Xiying, Schmidt, Hayden R., Song, Jinchun, Normandin, Marc D., Ran, Chongzhao, Wang, Changning

“…The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS),…”
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Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins by Bai, Ping, Lan, Yu, Wang, Hao, Chen, Zude, Fiedler, Stephanie, Striar, Robin, Lu, Xiaoxia, Wang, Changning

“…Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human…”
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LncRNA MAGI2-AS3 inhibites tumor progression by up-regulating STAM via interacting with miR-142-3p in clear cell renal cell carcinoma by Yang, Riwei, Chen, Zude, Ao, Shan, Liang, Leqi, Chen, Zugen, Duan, Xiaolu, Zeng, Guohua, Deng, Tuo

“…Revealing the role of non-coding RNAs (ncRNAs) in inducing dysregulated pathological responses to external signals may identify therapeutic targets for…”
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Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment by Yang, Riwei, Chen, Zude, Liang, Leqi, Ao, Shan, Zhang, Jinhu, Chang, Zhenglin, Wang, Zuomin, Zhou, Yuhao, Duan, Xiaolu, Deng, Tuo

“…Although recent studies have revealed the relationship between Fc Fragment of IgE Receptor Ig (FCER1G) and human tumours, there is still a lack of a more…”
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The relationship between gut microbiota and short chain fatty acids in the renal calcium oxalate stones disease by Liu, Yu, Jin, Xi, Hong, Hyokyoung G., Xiang, Liyuan, Jiang, Qingyao, Ma, Yucheng, Chen, Zude, Cheng, Liang, Jian, Zhongyu, Wei, Zhitao, Ai, Jianzhong, Qi, Shiqian, Sun, Qun, Li, Hong, Li, Yi, Wang, Kunjie

“…The relationship of gut microbiota and calcium oxalate stone has been limited investigated, especially with no study of gut microbiota and short chain fatty…”
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Synthesis of 11C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof by Chen, Zude, Wang, Xiashuang, Xu, Yulong, Wang, Changning

“…“Cell-cycle hypothesis” is emerging in recent years to suggest that aberrant cell cycle re-entry of differentiated neurons leads to a remarkable genetic…”
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Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease by Sang, Zhipei, Wang, Keren, Bai, Ping, Wu, Anguo, Shi, Jian, Liu, Wenmin, Zhu, Gaofeng, Wang, Yiling, Lan, Yu, Chen, Zude, Zhao, Yiyang, Qiao, Zhanpin, Wang, Changning, Tan, Zhenghuai

“…A novel series of O-carbamoyl ferulamide derivatives were designed by multitarget-directed ligands (MTDLs) strategy, the derivatives were synthesized and…”
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Noninvasive Positron Emission Tomography Imaging of SIRT1 in a Model of Early-Stage Alcoholic Liver Disease by Liu, Yan, Chen, Zude, Wang, Yanli, Hallisey, Madelyn Rose, Varela, Breanna Lizeth, Siewko, Anne, Tocci, Darcy, Wang, Changning, Xu, Yulong

“…Accrued evidence has indicated that epigenetic mechanisms altered by alcohol have been implicated in the progression and development of alcoholic liver disease…”
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Safety and Efficacy of Parenteral Fish Oil–Containing Lipid Emulsions in Premature Neonates by Zhao, Yiyang, Wu, Yang, Pei, Jiao, Chen, Zude, Wang, Qi, Xiang, Bo

“…ABSTRACT Objective: The aim of the study was to evaluate the safety and efficacy of fish oil–containing (FO) lipid emulsions that are rich in ω‐3 fatty acids…”
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Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins by Bai, Ping, Lan, Yu, Patnaik, Debasis, Wang, Hao, Liu, Yan, Chen, Zude, Yuan, Gengyang, Afshar, Sepideh, Striar, Robin, Zagaroli, Julia S, Tocci, Darcy R, Langan, Amelia G, Haggarty, Stephen J, Wang, Changning

“…To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based…”
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Molecular imaging of NAD+‐dependent deacetylase SIRT1 in the brain by Xu, Yulong, Chen, Zude, Wey, Hsiao‐Ying, Liang, Yingxia, Tanzi, Rudolph E., Zhang, Can, Wang, Changning

“…Introduction Aging is an inevitable physiological process and the biggest risk factor of Alzheimer's disease (AD). Developing an imaging tracer to visualize…”
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MP03-11 GUT MICROBIOME AND SHORT CHAIN FATTY ACIDS IN RENAL CALCIUM OXALATE STONES FORMATION by Wang, Kunjie, Liu, Yu, Zhou, Liang, Li, Yi, Sun, Qun, Chen, Zude, Jiang, Qingyao, Cheng, Liang, Tian, Lei, Li, Hong

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PET Imaging of Bromodomain and Extra-Terminal Domain Inhibitors for the Noninvasive Assessment of Metabolic Changes in the Liver and Brain of Early-Stage Alcoholic Liver Disease by Chen, Zude, Yang, Riwei, Xu, Yulong, Liang, Leqi, Ao, Shan, Wang, Zuomin, Bai, Ping, Gu, Di, Duan, Xiaolu, Liu, Yongda, Zhong, Wen, Xu, Peng, Deng, Tuo, Zeng, Guohua, Wang, Changning

“…Alcoholic liver disease (ALD) has a significant impact on human health and is one of the leading causes of liver disease mortality. The early and exact…”
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Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates by Xu, Yulong, Wang, Changning, Wey, Hsiao-Ying, Liang, Yingxia, Chen, Zude, Choi, Se Hoon, Ran, Chongzhao, Rynearson, Kevin D, Bernales, Daniela R, Koegel, Robert E, Fiedler, Stephanie A, Striar, Robin, Wagner, Steven L, Tanzi, Rudolph E, Zhang, Can

“…The pathogenesis of Alzheimer's disease (AD) is primarily driven by brain accumulation of the amyloid-β-42 (Aβ42) peptide generated from the amyloid-β…”
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Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins by Bai, Ping, Lu, Xiaoxia, Lan, Yu, Chen, Zude, Patnaik, Debasis, Fiedler, Stephanie, Striar, Robin, Haggarty, Stephen J., Wang, Changning

“…Bromodomain and extra-terminal domain (BET) family proteins play a vital role in the epigenetic regulation process by interacting with acetylated lysine (Ac-K)…”
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Synthesis of 11 C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof by Chen, Zude, Wang, Xiashuang, Xu, Yulong, Wang, Changning

“…"Cell-cycle hypothesis" is emerging in recent years to suggest that aberrant cell cycle re-entry of differentiated neurons leads to a remarkable genetic…”
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