Search Results - "Chen, Zinuo"

Expanding the tolerance of segmented Influenza A Virus genome using a balance compensation strategy by Zhao, Xiujuan, Lin, Xiaojing, Li, Ping, Chen, Zinuo, Zhang, Chengcheng, Manicassamy, Balaji, Rong, Lijun, Cui, Qinghua, Du, Ruikun

“…Reporter viruses provide powerful tools for both basic and applied virology studies, however, the creation and exploitation of reporter influenza A viruses…”
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Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases by Chen, Zinuo, Cui, Qinghua, Cooper, Laura, Zhang, Pin, Lee, Hyun, Chen, Zhaoyu, Wang, Yanyan, Liu, Xiaoyun, Rong, Lijun, Du, Ruikun

“…In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified…”
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Punicalagin is a neuraminidase inhibitor of influenza viruses by Li, Ping, Du, Ruikun, Chen, Zinuo, Wang, Yanyan, Zhan, Peng, Liu, Xinyong, Kang, Dongwei, Chen, Zhaoyu, Zhao, Xiujuan, Wang, Lin, Rong, Lijun, Cui, Qinghua

“…Influenza A virus (IAV) causes great morbidity and mortality worldwide every year. However, there are only a limited number of drugs clinically available…”
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SARS-CoV-2 cell entry and targeted antiviral development by Chen, Zinuo, Du, Ruikun, Galvan Achi, Jazmin M., Rong, Lijun, Cui, Qinghua

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19), which threatens human…”
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A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus by Zhao, Xiujuan, Wang, Yanyan, Cui, Qinghua, Li, Ping, Wang, Lin, Chen, Zinuo, Rong, Lijun, Du, Ruikun

“…Influenza A virus infections cause significant morbidity and mortality, and novel antivirals are urgently needed. Influenza RNA-dependent RNA polymerase (RdRp)…”
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Material basis and pharmacodynamic mechanism of YangshenDingzhi granules in the intervention of viral pneumonia: Based on serum pharmacochemistry and network pharmacology by Xu, Huirong, Dong, Meiyue, Du, Ruikun, Zhang, Chengcheng, Chen, Zinuo, Tian, Guangyu, Cui, Qinghua, Li, Kejian

“…Background YangshenDingzhi granules (YSDZ) are clinically effective in preventing and treating COVID‐19. The present study elucidates the underlying mechanism…”
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Combining virus-based affinity ultrafiltration method with serum pharmacochemistry to identify the antiviral pharmacodynamic substances in licorice by Li, Zhongyuan, Dong, Meiyue, Chen, Zinuo, Zhang, Chengcheng, Jiang, Jiayu, Liu, Miaomiao, Cui, Qinghua

“…Liorice (Glycyrrhiza uralensis Fisch.), a widely used Chinese herbal medicine, is frequently employed in clinical practice to treat viral pneumonia. However,…”
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Development of a virus‐based affinity ultrafiltration method for screening virus‐surface‐protein‐targeted compounds from complex matrixes: Herbal medicines as a case study by Li, Zhongyuan, Li, Baohong, Liu, Miaomiao, Chen, Zinuo, Li, Ping, Du, Ruikun, Su, Ming, Anirudhan, Varada, Achi, Jazmin G., Tian, Jingzhen, Rong, Lijun, Cui, Qinghua

“…Herbal medicines (HMs) are one of the main sources for the development of lead antiviral compounds. However, due to the complex composition of HMs, the…”
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Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro by Du, Ruikun, Cooper, Laura, Chen, Zinuo, Lee, Hyun, Rong, Lijun, Cui, Qinghua

“…The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date, there are limited therapeutic options available to fight this disease…”
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Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage by Li, Zhongyuan, Li, Baohong, Chen, Zinuo, Xu, Jinke, El Sabbagh, Asma, Zhao, Yangang, Du, Ruikun, Rong, Lijun, Tian, Jingzhen, Cui, Qinghua

“…Respiratory syncytial virus (RSV) causes lower respiratory tract diseases and bronchiolitis in children and elderly individuals. There are no effective drugs…”
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Revisiting influenza A virus life cycle from a perspective of genome balance by Du, Ruikun, Cui, Qinghua, Chen, Zinuo, Zhao, Xiujuan, Lin, Xiaojing, Rong, Lijun

“…Influenza A virus (IAV) genome comprises eight negative-sense RNA segments, of which the replication is well orchestrated and the delicate balance of multiple…”
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Sulforaphane is a reversible covalent inhibitor of 3‐chymotrypsin‐like protease of SARS‐CoV‐2 by Chen, Zinuo, Du, Ruikun, Cooper, Laura, Achi, Jazmin G., Dong, Meiyue, Ran, Yan, Zhang, Jiwei, Zhan, Peng, Rong, Lijun, Cui, Qinghua

“…The ongoing pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has posed a major public…”
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Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor by Dong, Meiyue, Wang, Yanyan, Li, Ping, Chen, Zinuo, Anirudhan, Varada, Cui, Qinghua, Rong, Lijun, Du, Ruikun

“…Influenza A virus (IAV) poses a global public health concern and remains an imminent threat to human health. Emerging antiviral resistance to the currently…”
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Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CL pro by Du, Ruikun, Cooper, Laura, Chen, Zinuo, Lee, Hyun, Rong, Lijun, Cui, Qinghua

“…The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date, there are limited therapeutic options available to fight this disease…”
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