Search Results - "Chen, Zhuchu"

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors by Dai, Shuyan, Zhou, Zhan, Chen, Zhuchu, Xu, Guangyu, Chen, Yongheng

“…Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both…”
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Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis by Wei, Hudie, Qu, Lingzhi, Dai, Shuyan, Li, Yun, Wang, Haolan, Feng, Yilu, Chen, Xiaojuan, Jiang, Longying, Guo, Ming, Li, Jun, Chen, Zhuchu, Chen, Lin, Zhang, Ye, Chen, Yongheng

“…The tumor suppressor p53 is mutated in approximately half of all human cancers. p53 can induce apoptosis through mitochondrial membrane permeabilization by…”
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Computational repositioning of dimethyl fumarate for treating alcoholic liver disease by Zhang, Ye, Zhao, Shuang, Fu, Ying, Yan, Lu, Feng, Yilu, Chen, Yaqi, Wu, Yijia, Deng, Yalan, Zhang, Guiying, Chen, Zhuchu, Chen, Yongheng, Liu, Ting

“…Alcoholic liver disease (ALD) is a chronic alcohol-induced disorder of the liver for which there are few effective therapies for severe forms of ALD and for…”
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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity by Wei, Hudie, Wang, Haolan, Wang, Genxin, Qu, Lingzhi, Jiang, Longying, Dai, Shuyan, Chen, Xiaojuan, Zhang, Ye, Chen, Zhuchu, Li, Youjun, Guo, Ming, Chen, Yongheng

“…Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53…”
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Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma by Li, Jingzhi, Guo, Ming, Chen, Lin, Chen, Zhuchu, Fu, Ying, Chen, Yongheng

“…Nasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Southeast Asia, especially in South China. The pathogenesis of NPC is complex,…”
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LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance by Wu, Daichao, Guo, Ming, Min, Xiaoli, Dai, Shuyan, Li, Meixiang, Tan, Sijie, Li, Guoqing, Chen, Xiaojuan, Ma, Yao, Li, Jun, Jiang, Longying, Qu, Lingzhi, Zhou, Zhan, Chen, Zhuchu, Chen, Lin, Xu, Guangyu, Chen, Yongheng

“…The chemical compound LY2874455 has the potential to overcome drug resistance driven by FGFR gatekeeper mutations. X-ray crystallographic studies provide the…”
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p53 amyloid aggregation in cancer: function, mechanism, and therapy by Li, Jingzhi, Guo, Ming, Chen, Lin, Chen, Zhuchu, Fu, Ying, Chen, Yongheng

“…Abstract Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has been proposed in recent years. p53, the most well-known…”
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Mass spectrometry-based proteomic capture of proteins bound to the MACC1 promoter in colon cancer by Huang, Yahui, Xiang, Yi, Xie, Zhongpeng, Cai, Yuxiang, Yang, Qiongzhi, Huang, Huichao, Chen, Zhuchu, Xiao, Zhefeng, He, Qiongqiong

“…MACC1 (metastasis associated in colon cancer 1) is a key driver that induces metastasis in colon cancer. However, the mechanisms by which MACC1 expression is…”
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Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer by He, Dan, Wang, Jun, Zhang, Chunfang, Shan, Bin, Deng, Xiyun, Li, Bin, Zhou, Yanwu, Chen, Wei, Hong, Jidong, Gao, Yang, Chen, Zhuchu, Duan, Chaojun

“…microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development…”
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Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site by Li, Jun, Dantas Machado, Ana Carolina, Guo, Ming, Sagendorf, Jared M, Zhou, Zhan, Jiang, Longying, Chen, Xiaojuan, Wu, Daichao, Qu, Lingzhi, Chen, Zhuchu, Chen, Lin, Rohs, Remo, Chen, Yongheng

“…FOXA2, a member of the forkhead family of transcription factors, plays essential roles in liver development and bile acid homeostasis. In this study, we report…”
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CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK by Fu, Ying, Zhang, Xiuzhi, Liang, Xujun, Chen, Yongheng, Chen, Zhuchu, Xiao, Zhefeng

“…Abstract Background Gelsolin-like capping actin protein (CapG) modulates actin dynamics and actin-based motility with a debatable role in tumorigenic…”
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Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 by Wu, Daichao, Guo, Ming, Philips, Michael A, Qu, Lingzhi, Jiang, Longying, Li, Jun, Chen, Xiaojuan, Chen, Zhuchu, Chen, Lin, Chen, Yongheng

“…Aberrant FGFR4 signaling has been documented abundantly in various human cancers. The majority of FGFR inhibitors display significantly reduced potency toward…”
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Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion by Chen, Yongheng, Zhang, Xiaojun, Dantas Machado, Ana Carolina, Ding, Yuan, Chen, Zhuchu, Qin, Peter Z, Rohs, Remo, Chen, Lin

“…The p53 core domain binds to response elements (REs) that contain two continuous half-sites as a cooperative tetramer, but how p53 recognizes discontinuous REs…”
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Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis by Li, Maoyu, Peng, Fang, Li, Guoqing, Fu, Yang, Huang, Ying, Chen, Zhuchu, Chen, Yongheng

“…Tumor microenvironment is crucial to tumor development and metastasis. Little is known about the roles of stromal proteins in colorectal carcinogenesis. In…”
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Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors by Qu, Lingzhi, Chen, Xiaojuan, Wei, Hudie, Guo, Ming, Dai, Shuyan, Jiang, Longying, Li, Jun, Yue, Sitong, Chen, Zhuchu, Chen, Yongheng

“…FIIN-2, TAS-120 (Futibatinib) and PRN1371 are highly potent pan-FGFR covalent inhibitors targeting the p-loop cysteine of FGFR proteins, of which TAS-120 and…”
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Correction to: Mass spectrometry-based proteomic capture of proteins bound to the MACC1 promoter in colon cancer by Huang, Yahui, Xiang, Yi, Xie, Zhongpeng, Cai, Yuxiang, Yang, Qiongzhi, Huang, Huichao, Chen, Zhuchu, Xiao, Zhefeng, He, Qiongqiong

“…In the original publication of the article, Acknowledgements section was published incorrectly. The correct Acknowledgements is given in this Correction…”
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Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells by Huang, Huichao, Fu, Ying, Duan, Yankun, Zhang, Ye, Lu, Miaolong, Chen, Zhuchu, Li, Maoyu, Chen, Yongheng

“…Suberoylanilide hydroxamic acid (SAHA), a famous histone deacetylase (HDAC) inhibitor, has been utilized in clinical treatment for cutaneous T-cell lymphoma…”
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Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma by Huang, Huichao, Huang, Fangling, Liang, Xujun, Fu, Ying, Cheng, Zhe, Huang, Yan, Chen, Zhuchu, Duan, Yankun, Chen, Yongheng

“…Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its radiosensitive effects in nasopharyngeal carcinoma (NPC). However, the detailed…”
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Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA by Jiang, Longying, Liu, Xueke, Liang, Xujun, Dai, Shuyan, Wei, Hudie, Guo, Ming, Chen, Zhuchu, Xiao, Desheng, Chen, Yongheng

“…Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological…”
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Detection and Analysis of RNAs Expression Profile for Methylated Candidate Tumor Suppressor Genes in Nasopharyngeal Carcinoma by Zhao, Shuang, Zhang, Ye, Liang, Xujun, Li, Maoyu, Peng, Fang, Chen, Zhuchu, Chen, Yongheng

“…DNA methylation, which acts as an expression regulator for multiple Tumor Suppressor Genes (TSGs), is believed to play an important role in Nasopharyngeal…”
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