Search Results - "Chen, Yuching"

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia by Keeton, Erika K., McEachern, Kristen, Dillman, Keith S., Palakurthi, Sangeetha, Cao, Yichen, Grondine, Michael R., Kaur, Surinder, Wang, Suping, Chen, Yuching, Wu, Allan, Shen, Minhui, Gibbons, Francis D., Lamb, Michelle L., Zheng, Xiaolan, Stone, Richard M., DeAngelo, Daniel J., Platanias, Leonidas C., Dakin, Les A., Chen, Huawei, Lyne, Paul D., Huszar, Dennis

“…Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2, and -3 promote cell proliferation and survival downstream of…”
Get full text

A New Type IV Secretion System Promotes Conjugal Transfer in Agrobacterium tumefaciens by Chen, Lishan, Chen, Yuching, Wood, Derek W, Nester, Eugene W

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor by Janes, Matthew R., Zhang, Jingchuan, Li, Lian-Sheng, Hansen, Rasmus, Peters, Ulf, Guo, Xin, Chen, Yuching, Babbar, Anjali, Firdaus, Sarah J., Darjania, Levan, Feng, Jun, Chen, Jeffrey H., Li, Shuangwei, Li, Shisheng, Long, Yun O., Thach, Carol, Liu, Yuan, Zarieh, Ata, Ely, Tess, Kucharski, Jeff M., Kessler, Linda V., Wu, Tao, Yu, Ke, Wang, Yi, Yao, Yvonne, Deng, Xiaohu, Zarrinkar, Patrick P., Brehmer, Dirk, Dhanak, Dashyant, Lorenzi, Matthew V., Hu-Lowe, Dana, Patricelli, Matthew P., Ren, Pingda, Liu, Yi

“…KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II…”
Get full text

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State by Patricelli, Matthew P, Janes, Matthew R, Li, Lian-Sheng, Hansen, Rasmus, Peters, Ulf, Kessler, Linda V, Chen, Yuching, Kucharski, Jeff M, Feng, Jun, Ely, Tess, Chen, Jeffrey H, Firdaus, Sarah J, Babbar, Anjali, Ren, Pingda, Liu, Yi

“…KRAS gain-of-function mutations occur in approximately 30% of all human cancers. Despite more than 30 years of KRAS-focused research and development efforts,…”
Get more information

An ear-decomposition based approach for survivable routing in WDM networks by SingLing Lee, Jung-Chun Liu, YuChing Chen

“…In WDM-based network, a single fiber abortion may cause many logical lightpaths failures such that embedded logical topology of a WDM network may become…”
Get full text

Abstract 686: Drugging an undruggable pocket: The biochemical mechanism of covalent KRASG12C inhibitors by Hansen, Rasmus, Peters, Ulf, Babbar, Anjali, Chen, Yuching, Feng, Jun, Janes, Matthew R., Li, Liansheng, Ren, Pingda, Liu, Yi, Zarrinkar, Patrick P.

“…Abstract We describe the biochemical mechanism of the covalent KRASG12C inhibitors ARS-853 and ARS-1620. Activating mutations in KRAS are among the most common…”
Get full text

The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors by Hansen, Rasmus, Peters, Ulf, Babbar, Anjali, Chen, Yuching, Feng, Jun, Janes, Matthew R., Li, Lian-Sheng, Ren, Pingda, Liu, Yi, Zarrinkar, Patrick P.

“…Activating mutations in KRAS are among the most common tumor driver mutations. Until recently, KRAS had been considered undruggable with small molecules; the…”
Get full text

Abstract 929: Discovery of novel covalent KRASG12C inhibitors that display high potency and selectivity in vitro and in vivo by Li, Liansheng, Janes, Matthew R., Zhang, Jingchuan, Hansen, Rasmus, Peters, Ulf, Guo, Xin, Chen, Yuching, Babbar, Anjali, Firdaus, Sarah J., Feng, Jun, Chen, Jeffrey H., Li, Shuangwei, Li, Shisheng, Thach, Carol, Liu, Yuan, Zarieh, Ata, Kucharski, Jeff M., Wu, Tao, Yu, Ke, Wang, Yi, Yao, Yvonne, Deng, Xiaohu, Zarrinkar, Patrick P., Dhanak, Dashyant, Lorenzi, Matthew V., Hu-Lowe, Dana, Ren, Pingda, Liu, Yi

“…Abstract Activating mutations in KRAS have a high prevalence in human cancer. The codon 12 glycine to cysteine missense mutation (KRASG12C) is among the most…”
Get full text

The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58 by Wood, Derek W., Setubal, Joao C., Kaul, Rajinder, Monks, Dave E., Kitajima, Joao P., Okura, Vagner K., Zhou, Yang, Chen, Lishan, Wood, Gwendolyn E., Almeida, Nalvo F., Woo, Lisa, Chen, Yuching, Paulsen, Ian T., Eisen, Jonathan A., Karp, Peter D., Bovee, Donald, Chapman, Peter, Clendenning, James, Deatherage, Glenda, Gillet, Will, Grant, Charles, Kutyavin, Tatyana, Levy, Ruth, Li, Meng-Jin, McClelland, Erin, Palmieri, Anthony, Raymond, Christopher, Rouse, Gregory, Saenphimmachak, Channakhone, Wu, Zaining, Romero, Pedro, Gordon, David, Zhang, Shiping, Yoo, Heayun, Tao, Yumin, Biddle, Phyllis, Jung, Mark, Krespan, William, Perry, Michael, Gordon-Kamm, Bill, Liao, Li, Kim, Sun, Hendrick, Carol, Zhao, Zuo-Yu, Dolan, Maureen, Chumley, Forrest, Tingey, Scott V., Tomb, Jean-Francois, Gordon, Milton P., Olson, Maynard V., Nester, Eugene W.

“…The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids…”
Get full text

The reactivity-driven biochemical mechanism of covalent KRAS G12C inhibitors by Hansen, Rasmus, Peters, Ulf, Babbar, Anjali, Chen, Yuching, Feng, Jun, Janes, Matthew R, Li, Lian-Sheng, Ren, Pingda, Liu, Yi, Zarrinkar, Patrick P

“…Activating mutations in KRAS are among the most common tumor driver mutations. Until recently, KRAS had been considered undruggable with small molecules; the…”
Get full text

Sports Video Summarization with Limited Labeling Datasets Based on 3D Neural Networks by Lin, ChingShun, Chen, YuChing

“…As more and more information generated, recorded, and distributed daily, the video summarization allows the spectators to focus on the clips mostly containing…”
Get full text

Abstract 2796: Efficacy and biomarker modulation by AZD1208, a novel, potent and selective pan-Pim kinase inhibitor, in models of acute myeloid leukemia by Keeton, Erika, McEachern, Kristen, Alimzhanov, Marat, Wang, Suping, Cao, Yichen, Bao, Larry, Palakurthi, Sangeetha, Grondine, Michael, Chen, Yuching, Dillman, Keith, Chinnappan, Dharmaraj, Shen, Minhui, Dakin, Les, Zheng, Xiaolan, Lamb, Michelle, Wu, Allan, Chen, Huawei, Lyne, Paul, Huszar, Dennis

“…Abstract The Pim serine/threonine kinase family is composed of three highly homologous members; Pim-1, Pim-2 and Pim-3, identified by the ability of the…”
Get full text

AZD1208, a Novel, Potent and Selective Pan PIM Kinase Inhibitor, Demonstrates Efficacy in Models of Acute Myeloid Leukemia by Keeton, Erika, Palakurthi, Sangeetha, Alimzhanov, Marat, Grondine, Michael, Chen, Yuching, Brown, Jeffrey, McEachern, Kristen, Cao, Yichen, Chinnappan, Dharmaraj, Shen, Minhui, Dakin, Les, Zheng, Xiao, Lamb, Michelle, Wu, Allan, Chen, Huawei, Lyne, Paul, Huszar, Dennis

“…Abstract 1540 The PIM serine/threonine kinase family is composed of three highly homologous members; PIM1, PIM2 and PIM3, identified by the ability of the…”
Get full text

A Novel Mutation in CD83 Results in the Development of a Unique Population of CD4+ T Cells by Garcia-Martinez, Leon F, Appleby, Mark W, Staehling-Hampton, Karen, Andrews, Dawn M, Chen, Yuching, McEuen, Mark, Tang, Phuong, Rhinehart, Rebecca L, Proll, Sean, Paeper, Bryan, Brunkow, Mary E, Grandea, Andres G., III, Howard, Edward D, Walker, Don E, Charmley, Patrick, Jonas, Mechthild, Shaw, Stevan, Latham, John A, Ramsdell, Fred

“…Using a mouse mutagenesis screen, we have identified CD83 as being critical for the development of CD4(+) T cells and for their function postactivation…”
Get full text

Agrobacterium type IV secretion is a two‐step process in which export substrates associate with the virulence protein VirJ in the periplasm by Pantoja, Mario, Chen, Lishan, Chen, Yuching, Nester, Eugene W.

“…Summary Type IV secretion systems are virulence determinants in many bacteria and share extensive homology with many conjugal transfer systems. Although type…”
Get full text

Immunohistochemical expression of p16INK4A, Ki-67, and Mcm2 proteins in gastrointestinal stromal tumors: prognostic implications and correlations with risk stratification of NIH consensus criteria by Huang, Hsuan-Ying, Huang, Wen-Wei, Lin, Ching-Nan, Eng, Hock-Liew, Li, Shau-Hsuan, Li, Chien-Feng, Lu, David, Yu, Shih-Chen, Hsiung, Ching-Yeh

“…Inactivation of p16(INK4A) promotes G1/S progression of cell cycle. Minichromosome maintenance protein-2 (Mcm2), a novel cell proliferation marker, is known to…”
Get full text