Search Results - "Chen, Yuanguang"

Study on the synthesis technology of anticancer drug Gilteritinib fumarate by Xu, Huashen, Chen, Lu, Chen, Yuanguang, Fu, Yang, Xu, Feng, Chen, Guoliang

“…Based on the reported routes, a convergent eight-step approach to Gilteritinib fumarate was designed, which is suitable for industrial implementation. The…”
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A mild protocol for the synthesis of N-methyltransferase G9a inhibitor BIX-01294 by Shi, Yajie, Chen, Yuanguang, Chen, Lu, Sun, Jianwen, Chen, Guoliang

“…A synthetic route to BIX-01294 was designed by means of retrosynthetic analysis and convergent synthesis. Using 2-amino-4,5-dimethoxybenzoic acid and urea as…”
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Stability analysis of rib pillars in highwall mining under dynamic and static loads in open-pit coal mine by Wu, Haoshuai, Chen, Yanlong, Lv, Haoyan, Xie, Qihang, Chen, Yuanguang, Gu, Jun

“…The retained coal in the end slope of an open-pit mine can be mined by the highwall mining techniques. However, the instability mechanism of the reserved rib…”
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Mechanical Properties and Penetration Characteristics of Mudstone Slag-Based Waterproof Composites under Cyclic Loading by Chen, Yuanguang, Chen, Yanlong, Zhang, Yafei, Zhang, Jialong, Chen, Tian

“…In this study, ground polymers were prepared from mudstone and slag. NaOH and water glass were used as alkaline exciters and mine waste rock aggregate was used…”
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Efficient reduction of quinoxaline compounds using zinc chloride—sodium borohydride system by Chen, Yuanguang, Xu, Huashen, Chen, Lu, Shi, Yajie, Hou, Anyuan, Liu, Zhongbo, Chen, Guoliang

“…Reagent system NaBH 4 —ZnCl 2 was found to be suitable for the reduction of various substituted quinoxalines to obtain corresponding 1,2,3,4-tetrahydro…”
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Dynamic mechanical properties and energy dissipation analysis of frozen sandstone with initial damage by Xie, Qihang, Chen, Yanlong, Lyu, Haoyan, Gu, Jun, Chen, Yuanguang, Cui, Huidong, Wu, Peng

“…Damaged rock masses on the slopes of open pit coal mines are prone to geological disasters such as landslides under low temperatures and dynamic loads such as…”
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Multicenter investigation of bowel evacuation function after transanal total mesorectal excision for mid-low rectal cancer by Shen, Zhanlong, Yu, Gang, Ren, Mingyang, Ding, Chao, Zhang, Hongyu, Li, Shuhua, Xu, Qing, Wang, Quan, Chen, Yuanguang, Xie, Zhongshi, Zhang, Qingtong, Ye, Kai, Xu, Xuedong, Xiang, Jianbin, Zhang, Hong, Yan, Su, Lu, Canrong, Yao, Hongwei, Zhang, Hao, Kang, Liang, Jiang, Kewei, Wang, Shan, Ye, Yingjiang

“…Purpose To determine the effect of transanal total mesorectal excision (taTME) procedure on the postoperative bowel evacuation function of patients with low…”
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2,2'-Dipyridylamine: A tripod ligand enabling practical access to diaryl ethers via Cu-catalyzed coupling reaction by Chen, Yuanguang, Xu, Huashen, Chen, Lu, Hou, Anyuan, Chen, Guoliang

“…2,2'-dipyridylamine (DPA) is hereby firstly reported as a novel and efficient tridentate ligand for promoting copper(I)-catalyzed C-O/S coupling reactions of…”
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“On Water” promoted N-arylation reactions using Cu (0)/myo-inositol catalytic system by Zhou, Qifan, Du, Fangyu, Chen, Yuanguang, Fu, Yang, Chen, Guoliang

“…[Display omitted] •Myo-inositol, a cardiovascular medicine, was used as tridentate O-donor ligand for Cu-catalyzed amination reaction in water.•The CN coupling…”
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Performance optimization and characterization of loess-slag-based geopolymer composite: A new sustainable green material for backfill by Lv, Haoyan, Chen, Yanlong, Xie, Qihang, Wu, Peng, Chen, Yuanguang, Gu, Jun, Wu, Haoshuai

“…[Display omitted] •Cemented backfill preparation with loess and slag.•Effect of loess percentage on workability of the cemented backfill.•Effects of loess…”
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Design, synthesis and evaluation of the novel chalcone derivatives with 2,2-dimethylbenzopyran as HIF-1 inhibitors that possess anti-angiogenic potential by Xu, Huashen, Wang, Jianmin, Chen, Yuanguang, Du, Yang, Chen, Lu, Wu, Chunfu, Wang, Lihui, Chen, Guoliang

“…Hypoxia-inducible factor-1 (HIF-1) as a key mediator in tumor metastasis, angiogenesis and poor patient prognosis, has been recognized as an important cancer…”
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l ‑(−)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N‑Arylation of Nitrogen-Containing Heterocycles by Zhou, Qifan, Du, Fangyu, Chen, Yuanguang, Fu, Yang, Sun, Wenjiao, Wu, Ying, Chen, Guoliang

“…l-(−)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides…”
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Design and Synthesis of sEH/HDAC6 Dual-Targeting Inhibitors for the Treatment of Inflammatory Pain by Xu, Huashen, Chen, Yuanguang, Tong, Hua, Chen, Lu, Morisseau, Christophe, Zhou, Zijian, Zhuang, Junning, Song, Chuqiao, Cai, Pengcheng, Liu, Zhongbo, Hammock, Bruce D., Chen, Guoliang

“…Soluble epoxide hydrolase (sEH) and HDAC6 mediate the NF-κB pathway in inflammatory responses, and their inhibitors exhibit powerful anti-inflammatory and…”
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Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases by Chen, Yuanguang, Chen, Lu, Xu, Huashen, Cao, Ruolin, Morisseau, Christophe, Zhang, Maoying, Shi, Yajie, Hammock, Bruce D., Wang, Jieru, Zhuang, Junning, Liu, Zhongbo, Chen, Guoliang

“…Soluble epoxide hydrolase (sEH) has been identified as an attractive target for anti-inflammatory drug design in recent years. Picomolar level compound G1…”
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Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality by Chen, Yuanguang, Sun, Jianwen, Tong, Hua, Wang, Jieru, Cao, Ruolin, Xu, Huashen, Chen, Lu, Morisseau, Christophe, Zhang, Maoying, Shi, Yajie, Han, Chao, Zhuang, Junning, Jing, Yongkui, Liu, Zhongbo, Hammock, Bruce D., Chen, Guoliang

“…Epoxyeicosatrienoic acids with anti-inflammatory effects are inactivated by soluble epoxide hydrolase (sEH). Both sEH and histone deacetylase 6 (HDAC6)…”
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Mangiferin prevents the growth of gastric carcinoma by blocking the PI3K-Akt signalling pathway by Du, Min, Wen, Gang, Jin, Juan, Chen, Yuanguang, Cao, Jun, Xu, Aman

“…The aim of the present study was to investigate the effects of mangiferin on gastric carcinoma cells and to determine the possible mechanisms underlying such…”
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2,2- dimethylbenzopyran derivatives containing pyridone structural fragments as selective dual-targeting inhibitors of HIF-1α and EZH2 for the treatment of lung cancer by Xu, Huashen, Zhang, Jie, Zhuang, Junning, Chen, Yuanguang, Chen, Lu, Wang, Jianmin, Cao, Ruolin, Liu, Fuqin, Wang, Kaibo, Zhang, Xiaoyu, Wang, Lihui, Chen, Guoliang

“…[Display omitted] •A series of 2,2- dimethylbenzopyran derivatives containing pyridone structural fragments were designed and synthesized with DYB-03, a HIF-1α…”
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Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agents by Du, Fangyu, Zhou, Qifan, Fu, Xiaoxiao, Shi, Yajie, Chen, Yuanguang, Fang, Wuhong, Yang, Jingyu, Chen, Guoliang

“…The development of novel neuroprotection agents is of great significance for the treatment of ischemic stroke. In this study, a series of compounds comprising…”
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Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis by Li, Chenggang, Li, Na, Liu, Xiaolei, Zhang, Erik Y, Sun, Yang, Masuda, Kouhei, Li, Jing, Sun, Julia, Morrison, Tasha, Li, Xiangke, Chen, Yuanguang, Wang, Jiang, Karim, Nagla A, Zhang, Yi, Blenis, John, Reginato, Mauricio J, Henske, Elizabeth P, Yu, Jane J

“…Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing mutations…”
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Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ra10424g by Du, Fangyu, Zhou, Qifan, Fu, Xiaoxiao, Shi, Yajie, Chen, Yuanguang, Fang, Wuhong, Yang, Jingyu, Chen, Guoliang

“…The development of novel neuroprotection agents is of great significance for the treatment of ischemic stroke. In this study, a series of compounds comprising…”
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