Search Results - "Chen, Yongheng"

Nanomaterials for cancer therapy: current progress and perspectives by Cheng, Zhe, Li, Maoyu, Dey, Raja, Chen, Yongheng

“…Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of…”
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Targeting MCL-1 in cancer: current status and perspectives by Wang, Haolan, Guo, Ming, Wei, Hudie, Chen, Yongheng

“…Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins…”
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Targeting p53 pathways: mechanisms, structures and advances in therapy by Wang, Haolan, Guo, Ming, Wei, Hudie, Chen, Yongheng

“…The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a…”
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Nanotechnology in cancer diagnosis: progress, challenges and opportunities by Zhang, Ye, Li, Maoyu, Gao, Xiaomei, Chen, Yongheng, Liu, Ting

“…In the fight against cancer, early detection is a key factor for successful treatment. However, the detection of cancer in the early stage has been hindered by…”
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Recent advances in therapeutic strategies for triple-negative breast cancer by Li, Yun, Zhang, Huajun, Merkher, Yulia, Chen, Lin, Liu, Na, Leonov, Sergey, Chen, Yongheng

“…Abstract Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current treatment options are limited…”
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Recent advances in systemic therapy for hepatocellular carcinoma by Zhang, Huajun, Zhang, Wuyang, Jiang, Longying, Chen, Yongheng

“…Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors in the world. Therapeutic options for advanced HCC are limited. Systemic…”
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Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors by Dai, Shuyan, Zhou, Zhan, Chen, Zhuchu, Xu, Guangyu, Chen, Yongheng

“…Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both…”
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Farnesoid X receptor (FXR): Structures and ligands by Jiang, Longying, Zhang, Huajun, Xiao, Desheng, Wei, Hudie, Chen, Yongheng

“…[Display omitted] Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand…”
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Thallium pollution in China and removal technologies for waters: A review by Liu, Juan, Luo, Xuwen, Sun, Yuqing, Tsang, Daniel C.W., Qi, Jianying, Zhang, Weilong, Li, Nuo, Yin, Meiling, Wang, Jin, Lippold, Holger, Chen, Yongheng, Sheng, Guodong

“…Thallium (Tl) is a typical toxic metal, which poses a great threat to human health through drinking water and the food chain (biomagnification). China has rich…”
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FGFR-TKI resistance in cancer: current status and perspectives by Yue, Sitong, Li, Yukun, Chen, Xiaojuan, Wang, Juan, Li, Meixiang, Chen, Yongheng, Wu, Daichao

“…Fibroblast growth factor receptors (FGFRs) play key roles in promoting the proliferation, differentiation, and migration of cancer cell. Inactivation of FGFRs…”
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Contamination, toxicity and speciation of heavy metals in an industrialized urban river: Implications for the dispersal of heavy metals by Wu, Qihang, Zhou, Haichao, Tam, Nora F.Y., Tian, Yu, Tan, Yang, Zhou, Song, Li, Qing, Chen, Yongheng, Leung, Jonathan Y.S.

“…Urban rivers are often utilized by the local residents as water source, but they can be polluted by heavy metals due to industrialization. Here, the…”
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Thallium contamination in farmlands and common vegetables in a pyrite mining city and potential health risks by Liu, Juan, Li, Nuo, Zhang, Weilong, Wei, Xudong, Tsang, Daniel C.W., Sun, Yubing, Luo, Xuwen, Bao, Zhi'an, Zheng, Wentao, Wang, Jin, Xu, Guoliang, Hou, Liping, Chen, Yongheng, Feng, Yuexing

“…Thallium (Tl) is a trace metal of severe toxicity. Its health concerns via consumption of contaminated vegetables have often been overlooked or underestimated…”
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Mechanism of uranium release from uranium mill tailings under long-term exposure to simulated acid rain: Geochemical evidence and environmental implication by Yin, Meiling, Sun, Jing, Chen, Yongheng, Wang, Jin, Shang, Jianying, Belshaw, Nick, Shen, ChuanChou, Liu, Juan, Li, Huosheng, Linghu, Wensheng, Xiao, Tangfu, Dong, Xinjiao, Song, Gang, Xiao, Enzong, Chen, Diyun

“…To date, there is not sufficient knowledge to fully understand the occurrence, transport and fate of residual uranium (U) from uranium mill tailings (UMT)…”
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Multi-Modal Co-Attention Capsule Network for Fake News Detection by Chunyan Yin, Yongheng Chen

“…Most of the existing fake news identification models mainly focused on exploiting multi-modal features to enhanced performance recently. This paper proposes M…”
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Response of microbial communities and interactions to thallium in contaminated sediments near a pyrite mining area by Liu, Juan, Yin, Meiling, Zhang, Weilong, Tsang, Daniel C.W., Wei, Xudong, Zhou, Yuting, Xiao, Tangfu, Wang, Jin, Dong, Xinjiao, Sun, Yubing, Chen, Yongheng, Li, Hui, Hou, Liping

“…Thallium (Tl) is a well-recognized hazardous heavy metal with very high toxicity. It is usually concentrated in sulfide minerals, such as pyrite (FeS2),…”
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Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer by Chen, Yongheng, Dey, Raja, Chen, Lin

“…Recent studies suggest that p53 binds predominantly to consensus sites composed of two decameric half-sites with zero spacing in vivo. Here we report the…”
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Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor by Dai, Shuyan, Qu, Lingzhi, Li, Jun, Zhang, Ye, Jiang, Longying, Wei, Hudie, Guo, Ming, Chen, Xiaojuan, Chen, Yongheng

“…The aryl hydrocarbon receptor (AHR), a member of the basic helix–loop–helix (bHLH) Per–Arnt–Sim (PAS) family of transcription factors, plays important roles in…”
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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity by Wei, Hudie, Wang, Haolan, Wang, Genxin, Qu, Lingzhi, Jiang, Longying, Dai, Shuyan, Chen, Xiaojuan, Zhang, Ye, Chen, Zhuchu, Li, Youjun, Guo, Ming, Chen, Yongheng

“…Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53…”
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Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis by Wei, Hudie, Qu, Lingzhi, Dai, Shuyan, Li, Yun, Wang, Haolan, Feng, Yilu, Chen, Xiaojuan, Jiang, Longying, Guo, Ming, Li, Jun, Chen, Zhuchu, Chen, Lin, Zhang, Ye, Chen, Yongheng

“…The tumor suppressor p53 is mutated in approximately half of all human cancers. p53 can induce apoptosis through mitochondrial membrane permeabilization by…”
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Lactylation-Related Gene Signature Effectively Predicts Prognosis and Treatment Responsiveness in Hepatocellular Carcinoma by Cheng, Zhe, Huang, Huichao, Li, Maoyu, Liang, Xujun, Tan, Yuying, Chen, Yongheng

“…Hepatocellular carcinoma (HCC) is a malignant tumor associated with high morbidity and mortality. Therefore, it is of great importance to develop effective…”
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