Search Results - "Chen, Yiyou"

Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review by Xin, Lei, Gao, Jinfang, Zheng, Ziliang, Chen, Yiyou, Lv, Shuxin, Zhao, Zhikai, Yu, Chunhai, Yang, Xiaotang, Zhang, Ruiping

“…Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically expressed by activated fibroblasts. Cancer-associated…”
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Combined Proteomic and Metabolomic Analysis of the Molecular Mechanism Underlying the Response to Salt Stress during Seed Germination in Barley by Chen, Yiyou, Wang, Juncheng, Yao, Lirong, Li, Baochun, Ma, Xiaole, Si, Erjing, Yang, Ke, Li, Chengdao, Shang, Xunwu, Meng, Yaxiong, Wang, Huajun

“…Salt stress is a major abiotic stress factor affecting crop production, and understanding of the response mechanisms of seed germination to salt stress can…”
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Rapid screening for individualized chemotherapy optimization of colorectal cancer: A novel conditional reprogramming technology-based functional diagnostic assay by Li, Yingjie, Guo, Dagang, Zhang, Yihong, Wang, Lin, Sun, Tingting, Li, Zhongwu, Zhang, Xiaoyan, Wang, Shuai, Chen, Yiyou, Wu, Aiwen

“…•Established a new in vitro tumor model called novel conditionally reprogrammed (termed i-CR).•Accomplished personalized drug tests within 2–3 weeks.•Achieved…”
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P1167: TREATMENT OF RELAPSED/REFRACTORY HGBCL WITH MYC REARRANGEMENT: A MULTICENTER, OPEN‐LABEL, PHASE 2 STUDY OF PC‐002(SEPB)，A FIRST‐IN‐CLASS INHIBITOR OF DEUBIQUITINASES TARGETING MYC DEGRADATION by Yoon, Sung‐Soo, LI, Zhiming, Zhou, Keshu, Zhou, Xiaoxi, Guo, Ye, Zhang, Huilai, Eom, Ki‐Seong, Jin Kim, Seok, Yong Oh, Sung, Lim, Sungnam, Youssoufian, Hagop, Jiang, Vernon C, Huang, Zanchun, Kilfoil, Georgina, Wang, Xin, Cao, Zhixiang, LI, Xiang, Wu, Alexander, Chen, Yiyou, Song, Yuqin

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On the Quantum Approximation of Normalized Schatten Norms by Chen, Yiyou

“…The similarity of quantum states has long been studied and some good measures such as Fidelity were developed. In this paper, we aim to come up with a…”
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Decoherence mitigation by embedding a logical qubit in a qudit by Miyahara, Hideyuki, Chen, Yiyou, Roychowdhury, Vwani, Bouchard, Louis-Serge

“…Quantum information stored in a qubit is rapidly lost to the environment. The realization of robust qubits is one of the most important challenges in quantum…”
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YM155 inhibits neuroblastoma growth through degradation of MYCN: A new role as a USP7 inhibitor by Li, Xiang, Yang, Feili, He, Na, Zhang, Ming, Lv, Yan, Yu, Yue, Dong, Qian, Hou, Xiaofu, Hao, Yanbing, An, Zhida, Zhang, Haiwen, Yang, Zhen, Zhai, Heiyan, Guo, Dagang, Cao, Zhixiang, Jiang, Vernon C., Chen, Yiyou

“…Amplification of the MYCN gene (MNA) is observed in approximately 25 to 35% of neuroblastoma patients, and is a well-recognized marker of tumor aggressiveness…”
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Treatment of Relapsed/Refractory Hgbcl and Bukitt's Lymphoma with c-Myc Rearrangement: A Multi-Center, Open-Label, Phase 2 Study of PC-002 (SepB), a First-in-Class Deubiquitinase Inhibitor Inducing Myc Degradation by Yoon, Sung-Soo, Li, Zhiming, Zhou, Keshu, Zhou, Xiaoxi, Guo, Ye, Zhang, Huilai, Eom, Ki-Seong, Kim, Seok Jin, Oh, Sung Yong, Lim, Sung-Nam, Youssoufian, Hagop, Jiang, Vernon, Huang, Zhanchun, Kilfoil, Georgina, Wang, Xin, Cao, Zhixiang, LI, Xiang, Lin, Yihai, Wu, Alexander, Chen, Yiyou, Song, Yuqin

“…Background: Burkitt lymphoma (BL) is one of the most aggressive B cell malignancies that is a high unmet need and characterized classically by c-Myc…”
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A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy by Zhang, Lianhai, Yang, Jie, Cai, Jie, Song, Xiaoming, Deng, Jianyun, Huang, Xuesong, Chen, Dawei, Yang, Mengmeng, Wery, Jean-Pierre, Li, Shuangxi, Wu, Aiwen, Li, Ziyu, Li, Zhongwu, Liu, Yiqiang, Chen, Yiyou, Li, Qixiang, Ji, Jiafu

“…A preclinical trial identified 4 of 20 (20%) gastric cancer (GC) patient-derived xenografts responded to cetuximab. Genome-wide profiling and additional…”
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Overcoming erlotinib resistance with tailored treatment regimen in patient‐derived xenografts from naïve Asian NSCLC patients by Yang, Mengmeng, Shan, Baoen, Li, Qiaoxia, Song, Xiaoming, Cai, Jie, Deng, Jianyun, Zhang, Likun, Du, Zhenjian, Lu, Junjie, Chen, Taiping, Wery, Jean‐Pierre, Chen, Yiyou, Li, Qixiang

“…Overall benefits of EGFR‐TKIs are limited because these treatments are largely only for adenocarcinoma (ADC) with EGFR activating mutation. The treatments also…”
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Conditionally reprogrammed colorectal cancer cells combined with mouse avatars identify synergy between EGFR and MEK or CDK4/6 inhibitors by Wang, Yanni, Liao, Haiyan, Zheng, Tongsen, Wang, Jingyuan, Guo, Dagang, Lu, Zhihao, Li, Zhongwu, Chen, Yiyou, Shen, Lin, Zhang, Yanqiao, Gao, Jing

“…Preclinical models, including patient-derived xenograft (PDX) and organoid and primary cell culture, are essential for studies of cancer cell biology and…”
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Determining the requirements for cooperative DNA binding by Swi5p and Pho2p (Grf10p/Bas2p) at the HO promoter by Brazas, R.M. (University of Utah Health Sciences Center, Salt Lake, City, UT.), Bhiote, L.T, Murphy, M.D, Yu, Y, Chen, Y, Neklason, D.W, Stillman, D.J

“…SWI5 encodes a zinc finger DNA binding protein required for the transcription of the Saccharomyces cerevisiae HO gene, and PHO2 encodes a homeodomain DNA…”
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Use of RAS pathway activation or KRAS mutation status to predict cetuximab response in CRC patient-derived xenografts by Li, Henry, Chen, Dawei, Guo, Sheng, Cai, Jie, Chen, Yiyou, Wery, Jean-Pierre

“…Abstract only 3544 Background: Cetuximab was approved for treating EGFR-expressing metastatic colorectal carcinoma (mCRC) without patient stratification…”
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Abstract 2784: Growth of patient derived tumor xenograft (PDX) in NOD/SCID mice reconstituted with human umbilical cord blood (UCB) CD34+ cells by An, Xiaoyu (Annie), Yang, Mengmeng, Wu, Ran, Liu, Jinping, Chen, Taiping, Wery, Jean-Pierre, Chen, Yiyou, Li, Henry

“…Abstract Patient derived xenograft (PDX) is closely reflective of tumor in patient for both histopathological and genetic profiles 1, 2. It thus becomes widely…”
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Abstract 5630: Treatments of NSCLC-PDX with c-MET gene amplification by c-MET inhibitors lead to rapid development of drug resistance by Yang, Mengmeng, Song, Xiaoming, Cai, JIe, Wang, Youzhu, Chen, Taiping, Wery, Jean-Pierre, Chen, Yiyou, Li, Henry

“…Abstract Drug resistance is one of important factors limiting effect of most cancer therapies. Understanding mechanisms causing resistance can facilitate…”
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Abstract 2344: PDX from the naïve NSCLC patients containing activating EGFR mutations are resistant to erlotinib but sensitive to c-met inhibitor by Yang, Mengmeng, Deng, Jiangyun, Song, Xiaoming, Cai, Jie, Chen, Taiping, Chen, Yiyou, Li, Henry Q.X.

“…Abstract NSCLC is a common cancer with the highest mortality and few effective treatment options, except for the patients with EGFR (Erlotinib, Iressa) and ALK…”
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Abstract 1322: Autocrine c-met/HGF HCC patient derived xenograft (PDX) models for evaluating c-met inhibitors by Chen, Dawei, Song, Xiaoming, Cai, Jie, Chen, Taiping, Chen, Yiyou, Li, Henry Q.X.

“…Abstract c-Met is a receptor tyrosine kinase that interacts with its ligand, HGF, secreted from surrounding stroma (paracrine signaling). This interaction is…”
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Abstract 4170: Primary Orthotopic Hepatocellular Carcinoma Models for Evaluation of Anticancer Drugs by Chen, Dawei, Chen, Taiping, Wery, Jean-Pierre, Chen, Yiyou

“…Abstract Human primary tumor model represents better alternatives for preclinical drug evaluation than cell lined derived xenograft models, due to its…”
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Abstract C62: 5A2, a new IL-3Ra (CD123) monoclonal antibody for the treatment of AML by Huang, Liang, Wang, Na, Wang, Huaying, Cao, Zhixiang, Chen, Yiyou, Li, Henry

“…Abstract Acute myeloblast leukemia (AML) is a classic stem cell disease driven by leukemic stem cells (LSCs). LSCs in general are resistant to the existing…”
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Abstract C113: Modeling cetuximab clinical trial by conducting in vivo efficacy evaluation in large panel CRC patient-derived xenograft (PDX) models by Chen, Dawei, Yang, Mengmeng, Deng, Jiangyun, Song, Xiaoming, Cai, Jie, Chen, Taiping, Chen, Yiyou, Li, Henry

“…Abstract Patient derived xenograft (PDX) models without in vitro manipulation mirror patients' histopathological and genetic profiles1,2. This has the…”
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