Search Results - "Chen, Y Grace"

Gene regulation in the immune system by long noncoding RNAs by Chen, Y Grace, Satpathy, Ansuman T, Chang, Howard Y

“…Long non-coding RNAs (lncRNAs) are being increasingly appreciated as important regulators of gene expression. Chang and colleagues review the roles identified…”
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NOD1 and NOD2 in inflammatory and infectious diseases by Trindade, Bruno C., Chen, Grace Y.

“…It has been long recognized that NOD1 and NOD2 are critical players in the host immune response, primarily by their sensing bacterial peptidoglycan‐conserved…”
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Role of the gut microbiota in immunity and inflammatory disease by Kamada, Nobuhiko, Seo, Sang-Uk, Chen, Grace Y., Núñez, Gabriel

“…Key Points The gut microbiota is important for the development and functional maturation of the gut immune system, including gut-associated lymphoid tissue, T…”
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Control of pathogens and pathobionts by the gut microbiota by Kamada, Nobuhiko, Chen, Grace Y, Inohara, Naohiro, Núñez, Gabriel

“…A dense resident microbial community in the gut, referred as the commensal microbiota, coevolved with the host and is essential for many host physiological…”
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The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline by Bailey, Alexis S, Batista, Pedro J, Gold, Rebecca S, Chen, Y Grace, de Rooij, Dirk G, Chang, Howard Y, Fuller, Margaret T

“…The switch from mitosis to meiosis is the key event marking onset of differentiation in the germline stem cell lineage. In , the translational repressor Bgcn…”
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Inflammasome activation in infected macrophages drives COVID-19 pathology by Sefik, Esen, Qu, Rihao, Junqueira, Caroline, Kaffe, Eleanna, Mirza, Haris, Zhao, Jun, Brewer, J. Richard, Han, Ailin, Steach, Holly R., Israelow, Benjamin, Blackburn, Holly N., Velazquez, Sofia E., Chen, Y. Grace, Halene, Stephanie, Iwasaki, Akiko, Meffre, Eric, Nussenzweig, Michel, Lieberman, Judy, Wilen, Craig B., Kluger, Yuval, Flavell, Richard A.

“…Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of…”
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Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis by Chen, Grace Y.

“…There has been significant interest in understanding how interactions between the host immune system and the gut microbiota regulate intestinal homeostasis…”
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The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection by Hara, Hideki, Seregin, Sergey S., Yang, Dahai, Fukase, Koichi, Chamaillard, Mathias, Alnemri, Emad S., Inohara, Naohiro, Chen, Grace Y., Núñez, Gabriel

“…The activator and composition of the NLRP6 inflammasome remain poorly understood. We find that lipoteichoic acid (LTA), a molecule produced by Gram-positive…”
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A functional role for Nlrp6 in intestinal inflammation and tumorigenesis by Chen, Grace Y, Liu, Maochang, Wang, Fuyuan, Bertin, John, Núñez, Gabriel

“…The nucleotide-binding oligomerization domain-like receptor (NLR) family member, Nlrp6, has been implicated in inflammasome signaling to activate caspase-1,…”
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Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling by Li, Zhengqiu, Hao, Piliang, Li, Lin, Tan, Chelsea Y. J., Cheng, Xiamin, Chen, Grace Y. J., Sze, Siu Kwan, Shen, Han-Ming, Yao, Shao Q.

“…Less is more: A minimalist “clickable” photo‐crosslinker (see scheme) was incorporated with numerous small‐molecule kinase inhibitors. The resulting probes…”
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Gut microbiota and systemic immunity in health and disease by Lo, Bernard C, Chen, Grace Y, Núñez, Gabriel, Caruso, Roberta

“…Effects of gut microbiota on systemic immunity Abstract The mammalian intestine is colonized by trillions of microorganisms that have co-evolved with the host…”
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Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes by Shi, Haibin, Zhang, Chong-Jing, Chen, Grace Y. J, Yao, Shao Q

“…Protein kinases (PKs) play an important role in the development and progression of cancer by regulating cell growth, survival, invasion, metastasis, and…”
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The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes by Kim, Yun-Gi, Kamada, Nobuhiko, Shaw, Michael H., Warner, Neil, Chen, Grace Y., Franchi, Luigi, Núñez, Gabriel

“…The intracellular sensor Nod2 is activated in response to bacteria, and the impairment of this response is linked to Crohn's disease. However, the function of…”
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Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element by Cho, Seung Woo, Xu, Jin, Sun, Ruping, Mumbach, Maxwell R., Carter, Ava C., Chen, Y. Grace, Yost, Kathryn E., Kim, Jeewon, He, Jing, Nevins, Stephanie A., Chin, Suet-Feung, Caldas, Carlos, Liu, S. John, Horlbeck, Max A., Lim, Daniel A., Weissman, Jonathan S., Curtis, Christina, Chang, Howard Y.

“…Noncoding mutations in cancer genomes are frequent but challenging to interpret. PVT1 encodes an oncogenic lncRNA, but recurrent translocations and deletions…”
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NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila by Seregin, Sergey S., Golovchenko, Natasha, Schaf, Bryan, Chen, Jiachen, Pudlo, Nicholas A., Mitchell, Jonathan, Baxter, Nielson T., Zhao, Lili, Schloss, Patrick D., Martens, Eric C., Eaton, Kathryn A., Chen, Grace Y.

“…Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of…”
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The gut microbiome modulates colon tumorigenesis by Zackular, Joseph P, Baxter, Nielson T, Iverson, Kathryn D, Sadler, William D, Petrosino, Joseph F, Chen, Grace Y, Schloss, Patrick D

“…Recent studies have shown that individuals with colorectal cancer have an altered gut microbiome compared to healthy controls. It remains unclear whether these…”
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Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis by Yu, Amy I., Zhao, Lili, Eaton, Kathryn A., Ho, Sharon, Chen, Jiachen, Poe, Sara, Becker, James, Gonzalez, Allison, McKinstry, Delaney, Hasso, Muneer, Mendoza-Castrejon, Jonny, Whitfield, Joel, Koumpouras, Charles, Schloss, Patrick D., Martens, Eric C., Chen, Grace Y.

“…There is increasing evidence that gut microbiome perturbations, also known as dysbiosis, can influence colorectal cancer development. To understand the…”
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Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel by Han, Kai, Nam, Jutaek, Xu, Jin, Sun, Xiaoqi, Huang, Xuehui, Animasahun, Olamide, Achreja, Abhinav, Jeon, Jin Heon, Pursley, Benjamin, Kamada, Nobuhiko, Chen, Grace Y., Nagrath, Deepak, Moon, James J.

“…The performance of immune-checkpoint inhibitors, which benefit only a subset of patients and can cause serious immune-related adverse events, underscores the…”
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Induction of Bone Loss by Pathobiont-Mediated Nod1 Signaling in the Oral Cavity by Jiao, Yizu, Darzi, Youssef, Tawaratsumida, Kazuki, Marchesan, Julie T., Hasegawa, Mizuho, Moon, Henry, Chen, Grace Y., Núñez, Gabriel, Giannobile, William V., Raes, Jeroen, Inohara, Naohiro

“…Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune…”
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Flavonoids and Colorectal Cancer Prevention by Li, Yanyan, Zhang, Tao, Chen, Grace Y

“…Colorectal cancer (CRC) is the third most common cancer, but despite advances in treatment, it remains the second most common cause of cancer-related…”
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