Search Results - "Chen, Xiusheng"

Genetically modified large animal models for investigating neurodegenerative diseases by Yang, Weili, Chen, Xiusheng, Li, Shihua, Li, Xiao-Jiang

“…Neurodegenerative diseases represent a large group of neurological disorders including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease,…”
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Spatiotemporal Variation Characteristics of Droughts and Their Connection to Climate Variability and Human Activity in the Pearl River Basin, South China by Cui, Lilu, Chen, Xiusheng, An, Jiachun, Yao, Chaolong, Su, Yong, Zhu, Chengkang, Li, Yu

“…Droughts have damaging impacts on human society and ecological environments. Therefore, studying the impacts of climate variability and human activity on…”
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Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease by Zhang, Yiran, Chen, Xiusheng, Chen, Laiqiang, Shao, Mingting, Zhu, Wenzhen, Xing, Tingting, Guo, Tingting, Jia, Qingqing, Yang, Huiming, Yin, Peng, Yan, Xiao-Xin, Yu, Jiandong, Li, Shihua, Li, Xiao-Jiang, Yang, Su

“…The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer's disease (AD) brain, but how ER stress contributes to the…”
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Mitochondrial-Dependent and Independent Functions of PINK1 by Chen, Xiusheng, Wang, Qi, Li, Shihua, Li, Xiao-Jiang, Yang, Weili

“…PINK1 has been characterized as a mitochondrial kinase that can target to damaged mitochondria to initiate mitophagy, a process to remove unhealthy…”
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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles by Liu, Yanting, Huang, Wei, Wen, Jiayi, Xiong, Xin, Xu, Ting, Wang, Qi, Chen, Xiusheng, Zhao, Xianxian, Li, Shihua, Li, Xiaojiang, Yang, Weili

“…JOURNAL/nrgr/04.03/01300535-202504000-00028/figure1/v/2024-07-06T104127Z/r/image-tiff The vast majority of in vitro studies have demonstrated that PINK1…”
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Brain Region- and Age-Dependent 5-Hydroxymethylcytosine Activity in the Non-Human Primate by Xu, Yanru, Zhong, Liying, Wei, Huixian, Li, Yuwei, Xie, Jiaxiang, Xie, Leijie, Chen, Xiusheng, Guo, Xiangyu, Yin, Peng, Li, Shihua, Zeng, Junwei, Li, Xiao-Jiang, Lin, Li

“…Because of the difficulty in collecting fresh brains of humans at different ages, it remains unknown how epigenetic regulation occurs in the primate brains…”
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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin by Li, Caijuan, Lin, Yingqi, Chen, Yizhi, Song, Xichen, Zheng, Xiao, Li, Jiawei, He, Jun, Chen, Xiusheng, Huang, Chunhui, Wang, Wei, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Tu, Zhuchi, Li, Xiao‐Jiang, Yan, Sen, Li, Shihua

“…Abstract Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's…”
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CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate by Li, Bang, Zhao, Hui, Tu, Zhuchi, Yang, Weili, Han, Rui, Wang, Lu, Luo, Xiaopeng, Pan, Mingtian, Chen, Xiusheng, Zhang, Jiawei, Xu, Huijuan, Guo, Xiangyu, Yan, Sen, Yin, Peng, Zhao, Zhiguang, Liu, Jianrong, Luo, Yafeng, Li, Yuefeng, Yang, Zhengyi, Zhang, Baogui, Tan, Zhiqiang, Xu, Hao, Jiang, Tianzi, Jiang, Yong-hui, Li, Shihua, Zhang, Yong Q., Li, Xiao-Jiang

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding…”
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CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys by Yang, Weili, Liu, Yunbo, Tu, Zhuchi, Xiao, Chong, Yan, Sen, Ma, Xishan, Guo, Xiangyu, Chen, Xiusheng, Yin, Peng, Yang, Zhengyi, Yang, Su, Jiang, Tianzi, Li, Shihua, Qin, Chuan, Li, Xiao-Jiang

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Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models by Han, Rui, Wang, Qi, Xiong, Xin, Chen, Xiusheng, Tu, Zhuchi, Li, Bang, Zhang, Fei, Chen, Chunyu, Pan, Mingtian, Xu, Ting, Chen, Laiqiang, Wang, Zhifu, Liu, Yanting, He, Dajian, Guo, Xiangyu, He, Feng, Wu, Peng, Yin, Peng, Liu, Yunbo, Yan, Xiaoxin, Li, Shihua, Li, Xiao-Jiang, Yang, Weili

“…Parkinson's disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated α-synuclein (pS129-α-syn). The…”
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Deficiency of parkin causes neurodegeneration and accumulation of pathological [alpha]-synuclein in monkey models by Han, Rui, Wang, Qi, Xiong, Xin, Chen, Xiusheng, Tu, Zhuchi, Li, Bang, Zhang, Fei, Chen, Chunyu, Pan, Mingtian, Xu, Ting, Chen, Laiqiang, Wang, Zhifu, Liu, Yanting, He, Dajian, Guo, Xiangyu, He, Feng, Wu, Peng, Yin, Peng, Liu, Yunbo, Yan, Xiaoxin, Li, Shihua, Li, Xiao-Jiang, Yang, Weili

“…Parkinson's disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated [alpha]-synuclein…”
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PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis by Yang, Weili, Guo, Xiangyu, Tu, Zhuchi, Chen, Xiusheng, Han, Rui, Liu, Yanting, Yan, Sen, Wang, Qi, Wang, Zhifu, Zhao, Xianxian, Zhang, Yunpeng, Xiong, Xin, Yang, Huiming, Yin, Peng, Wan, Huida, Chen, Xingxing, Guo, Jifeng, Yan, Xiao-Xin, Liao, Lujian, Li, Shihua, Li, Xiao-Jiang

“…In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in…”
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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) by Li, Caijuan, Lin, Yingqi, Chen, Yizhi, Song, Xichen, Zheng, Xiao, Li, Jiawei, He, Jun, Chen, Xiusheng, Huang, Chunhui, Wang, Wei, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Tu, Zhuchi, Li, Xiao‐Jiang, Yan, Sen, Li, Shihua

“…Lysosome In article number 2301120 , Xiao‐Jiang Li, Sen Yan, Shihua Li, and their colleagues utilized a small intrabody peptide linked to lysosomes to…”
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GLPP: A Game-Based Location Privacy-Preserving Framework in Account Linked Mixed Location-Based Services by Liu, Bo, Xu, Shuai, Chen, Xiusheng, Cao, Jiuxin, Ma, Zhuo, Yang, Yuntao

“…In Location-Based Services (LBSs) platforms, such as Foursquare and Swarm, the submitted position for a share or search leads to the exposure of users’…”
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Augmenter of liver regeneration (ALR) restrains concanavalin A-induced hepatitis in mice by Mu, Mao, Zhang, Zhenwei, Cheng, Yi, Liu, Guangze, Chen, Xiusheng, Wu, Xin, Zhuang, Caifang, Liu, Bingying, Kong, Xiangping, You, Song

“…Augmenter of liver regeneration (ALR), produced and released by hepatocytes, has cytoprotective and immunoregulatory effects on liver injury, and has been used…”
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Study on the Surface Roughness and Surface Shape Simulation Based on STEP-NC Turning by Xiusheng Chen, Chengrui Zhang, Riliang Liu, Hongbo Lan

“…Surface roughness and surface shape simulation are presented for the intelligent STEP-NC turning controller in this paper. Simulation models for surface…”
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Development of Lengthening I-beam Steel-Work Automatic Welder Based on Open CNC System by Cao Shukun, Wang Changlei, Qian Yuxia, Chen Xiusheng, Zhang Fangyou

“…In order to meet the needs of particular models I-steel production, design a lengthening I-beam steel-work automatic welding machine. Introduce the body of…”
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