Search Results - "Chen, Weisheng V"

Clustered protocadherins by Chen, Weisheng V, Maniatis, Tom

“…The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic locus, and this remarkable genomic organization is highly conserved…”
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Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly by Mountoufaris, George, Canzio, Daniele, Nwakeze, Chiamaka L, Chen, Weisheng V, Maniatis, Tom

“…The ability of neurites of individual neurons to distinguish between themselves and neurites from other neurons and to avoid self (self-avoidance) plays a key…”
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Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly by Mountoufaris, George, Chen, Weisheng V., Hirabayashi, Yusuke, O’Keeffe, Sean, Chevee, Maxime, Nwakeze, Chiamaka L., Polleux, Franck, Maniatis, Tom

“…The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Here, we show…”
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Single-Cell Identity Generated by Combinatorial Homophilic Interactions between α, β, and γ Protocadherins by Thu, Chan Aye, Chen, Weisheng V., Rubinstein, Rotem, Chevee, Maxime, Wolcott, Holly N., Felsovalyi, Klara O., Tapia, Juan Carlos, Shapiro, Lawrence, Honig, Barry, Maniatis, Tom

“…Individual mammalian neurons stochastically express distinct repertoires of α, β, and γ protocadherin (Pcdh) proteins, which function in neural circuit…”
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hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function by Ye, Junqiang, Beetz, Nadine, O’Keeffe, Sean, Tapia, Juan Carlos, Macpherson, Lindsey, Chen, Weisheng V., Bassel-Duby, Rhonda, Olson, Eric N., Maniatis, Tom

“…Significance We studied the physiological function of the heterogeneous nuclear ribonucleoprotein U (hnRNP U) by generating a conditional knockout mouse in…”
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Highly efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression by Li, Xiao-Lan, Li, Guo-Hua, Fu, Juan, Fu, Ya-Wen, Zhang, Lu, Chen, Wanqiu, Arakaki, Cameron, Zhang, Jian-Ping, Wen, Wei, Zhao, Mei, Chen, Weisheng V, Botimer, Gary D, Baylink, David, Aranda, Leslie, Choi, Hannah, Bechar, Rachel, Talbot, Prue, Sun, Chang-Kai, Cheng, Tao, Zhang, Xiao-Bing

“…Abstract Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine…”
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Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster by Chen, Weisheng V., Alvarez, Francisco J., Lefebvre, Julie L., Friedman, Brad, Nwakeze, Chiamaka, Geiman, Eric, Smith, Courtney, Thu, Chan Aye, Tapia, Juan Carlos, Tasic, Bosiljka, Sanes, Joshua R., Maniatis, Tom

“…The mammalian Protocadherin (Pcdh) alpha, beta, and gamma gene clusters encode a large family of cadherin-like transmembrane proteins that are differentially…”
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Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity by Ramalingam, Nagendran, Jin, Shan-Xue, Moors, Tim E., Fonseca-Ornelas, Luis, Shimanaka, Kazuma, Lei, Shi, Cam, Hugh P., Watson, Aurelia Hays, Brontesi, Lisa, Ding, Lai, Hacibaloglu, Dinc Yasat, Jiang, Haiyang, Choi, Se Joon, Kanter, Ellen, Liu, Lei, Bartels, Tim, Nuber, Silke, Sulzer, David, Mosharov, Eugene V., Chen, Weisheng V., Li, Shaomin, Selkoe, Dennis J., Dettmer, Ulf

“…In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology…”
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Protocadherins mediate dendritic self-avoidance in the mammalian nervous system by Lefebvre, Julie L., Kostadinov, Dimitar, Chen, Weisheng V., Maniatis, Tom, Sanes, Joshua R.

“…Protocadherins are found to potentially provide the molecular diversity and complexity required to promote dendritic self-avoidance in mouse retina and…”
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Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster by Chen, Weisheng V., Alvarez, Francisco J., Lefebvre, Julie L., Friedman, Brad, Nwakeze, Chiamaka, Geiman, Eric, Smith, Courtney, Thu, Chan Aye, Tapia, Juan Carlos, Tasic, Bosiljka, Sanes, Joshua R., Maniatis, Tom

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Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis by Soriano, Philippe, Chen, Weisheng V, Delrow, Jeffrey, Corrin, Philip D, Frazier, Jason P

“…We developed a versatile, high-throughput genetic screening strategy by coupling gene mutagenesis and expression profiling technologies. Using a retroviral…”
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Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice by Chen, Weisheng V., Nwakeze, Chiamaka L., Denny, Christine A., O’Keeffe, Sean, Rieger, Michael A., Mountoufaris, George, Kirner, Amy, Dougherty, Joseph D., Hen, René, Wu, Qiang, Maniatis, Tom

“…Serotonergic neurons project their axons pervasively throughout the brain and innervate various target fields in a space-filling manner, leading to tiled…”
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Molecular and functional interaction between protocadherin-γC5 and GABAA receptors by Li, Yanfang, Xiao, Haiyan, Chiou, Tzu-Ting, Jin, Hongbing, Bonhomme, Bevan, Miralles, Celia P, Pinal, Noelia, Ali, Rashid, Chen, Weisheng V, Maniatis, Tom, De Blas, Angel L

“…We have found that the γ2 subunit of the GABA(A) receptor (γ2-GABA(A)R) specifically interacts with protocadherin-γC5 (Pcdh-γC5) in the rat brain. The…”
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Gene trap mutagenesis in embryonic stem cells by Chen, Weisheng V, Soriano, Philippe

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Differentiation trapping screen in live culture for genes expressed in cardiovascular lineages by Chen, Weisheng V., Chen, Zhi

“…We have developed a gene trap vector that transduces an EGFP‐neo fusion gene (Eno) to monitor the expression of trapped genes in living cells and embryos. Upon…”
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Molecular and Functional Interaction between Protocadherin-γC5 and GABA A Receptors by Li, Yanfang, Xiao, Haiyan, Chiou, Tzu-Ting, Jin, Hongbing, Bonhomme, Bevan, Miralles, Celia P., Pinal, Noelia, Ali, Rashid, Chen, Weisheng V., Maniatis, Tom, De Blas, Angel L.

“…We have found that the γ2 subunit of the GABA A receptor (γ2-GABA A R) specifically interacts with protocadherin-γC5 (Pcdh-γC5) in the rat brain. The…”
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Pcdh[alpha]c2 is required for axonal tiling and assembly of serotonergic circuitries in mice by Chen, Weisheng V, Nwakeze, Chiamaka L, Denny, Christine A, O'Keeffe, Sean, Rieger, Michael A, Mountoufaris, George, Kirner, Amy, Dougherty, Joseph D, Hen, René, Wu, Qiang, Maniatis, Tom

“…Neurons in the developing brain cooperate to build circuits. Mountoufaris et al. found that ∼50 variable protocadherin genes support a combinatorial identity…”
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Generation of single cell identity by homophilic interactions between combinations of α, β and γ protocadherins by Thu, Chan Aye, Chen, Weisheng V., Rubinstein, Rotem, Chevee, Maxime, Wolcott, Holly N, Felsovalyi, Klara O, Tapia, Juan Carlos, Shapiro, Lawrence, Honig, Barry, Maniatis, Tom

“…Individual mammalian neurons express distinct repertoires of protocadherin (Pcdh) -α, -β and -γ proteins that function in neural circuit assembly. Here we show…”
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