Search Results - "Chen, Weishen"

An injectable CS-hydrogel incorporating TPGS for cartilage repair by Tu, Qingqiang, Jiang, Dong, Hu, Rongcheng, Liu, Yong, Fu, Xihong, Chen, Weishen, Zhang, Ziji, Liu, Chun

“…[Display omitted] •Pioneered use of intra-articular injection of D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) to treat osteoarthritis.•Applied a…”
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Serum globulin and albumin to globulin ratio as potential diagnostic biomarkers for periprosthetic joint infection: a retrospective review by Ye, Yongyu, Chen, Weishen, Gu, Minghui, Xian, Guoyan, Pan, Baiqi, Zheng, Linli, Zhang, Ziji, Sheng, Puyi

“…Abstract Background Periprosthetic joint infection (PJI) has been increasingly documented; however, its preoperative accurate diagnosis remains challenging…”
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Advanced glycation end products biphasically modulate bone resorption in osteoclast-like cells by Li, Ziqing, Li, Chaohong, Zhou, Yuhuan, Chen, Weishen, Luo, Guotian, Zhang, Ziji, Wang, Haixing, Zhang, Yangchun, Xu, Dongliang, Sheng, Puyi

“…Advanced glycation end products (AGEs) disturb bone remodeling during aging, and this process is accelerated in diabetes. However, their role in modulation of…”
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MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2 by Zhang, Zhiqi, Hou, Changhe, Meng, Fangang, Zhao, Xiaoyi, Zhang, Ziji, Huang, Guangxin, Chen, Weishen, Fu, Ming, Liao, Weiming

“…•MiR-455-3p is a chondrogenic related microRNA.•MiR-455-3p is shown to function as an activator in early chondrogenesis by inhibiting Runx2.•MiR-455-3p may…”
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Identification and Characterization of Long Non-Coding RNAs in Osteogenic Differentiation of Human Adipose-Derived Stem Cells by Huang, Guangxin, Kang, Yan, Huang, Zhiyu, Zhang, Zhiqi, Meng, Fangang, Chen, Weishen, Fu, Ming, Liao, Weiming, Zhang, Ziji

“…Background/Aims: Long noncoding RNAs (lncRNAs) play important roles in stem cell differentiation. However, their role in osteogenesis of human adipose-derived…”
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MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression by Chen, Weishen, Sheng, Puyi, Huang, Zhiyu, Meng, Fangang, Kang, Yan, Huang, Guangxin, Zhang, Zhiqi, Liao, Weiming, Zhang, Ziji

“…Chondrocyte hypertrophy, regulated by Runt-related transcription factor 2 (RUNX2) and matrix metalloproteinase 13 (MMP13), is a crucial step in cartilage…”
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Deconvolution of synovial myeloid cell subsets across pathotypes and role of COL3A1+ macrophages in rheumatoid arthritis remission by Hu, Xuantao, Zhang, Ziji, Long, Lingli, Gu, Minghu, Chen, Weishen, Pan, Baiqi, Wu, Xiaoyu, Wang, Chao, Li, Chengxin, Zheng, Linli, Sheng, Puyi

“…Monocyte/macrophage (Mo/Mp) is a critical cell population involved in immune modulation of rheumatoid synovitis (RA) across different pathotypes. This study…”
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Association of thyroid hormone with osteoarthritis: from mendelian randomization and RNA sequencing analysis by Li, Chengxin, Tu, Yucheng, Rong, Rong, Zhang, Ziji, Chen, Weishen, Long, Lingli, Zhang, Yangchun, Wang, Chao, Pan, Baiqi, Wu, Xiaoyu, Guan, Mingqiang, Yang, Bo, Zheng, Linli, Sheng, Puyi

“…The relationship between thyroid hormone (TH) levels in vivo and osteoarthritis (OA) remains inconclusive. This study aims to investigate the association…”
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The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses by Hou, Changhe, Meng, Fangang, Zhang, Zhiqi, Kang, Yan, Chen, Weishen, Huang, Guangxin, Fu, Ming, Sheng, Puyi, Zhang, Ziji, Liao, Weiming

“…Aim: The molecular pathways regulating cartilage degradation are unclear. miR-381 was identified as a putative regulator of chondrogenesis related genes. Here,…”
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Limited value of serum neutrophil-to-lymphocyte ratio in the diagnosis of chronic periprosthetic joint infection by Ye, Yongyu, Chen, Weishen, Gu, Minghui, Liu, Qiaoli, Xian, Guoyan, Pan, Baiqi, Zheng, Linli, Chen, Xiaoling, Zhang, Ziji, Sheng, Puyi

“…Background Diagnosing chronic periprosthetic joint infection (PJI) is challenging. No single biomarker can accurately recognize PJI preoperatively in a timely…”
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SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis by Gu, Minghui, Pan, Baiqi, Chen, Weishen, Xu, Hai, Wu, Xiaoyu, Hu, Xuantao, Zheng, Linli, Ye, Yongyu, Meng, Qing, Xian, Guoyan, Zhang, Ziji, Sheng, Puyi

“…Inflammatory osteolysis induced by wear particles is the major cause of prosthetic loosening after artificial joint replacement, and its prevention and…”
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A machine learning-based model for "In-time" prediction of periprosthetic joint infection by Chen, Weishen, Hu, Xuantao, Gu, Chen, Zhang, Zhaohui, Zheng, Linli, Pan, Baiqi, Wu, Xiaoyu, Sun, Wei, Sheng, Puyi

“…Previous criteria had limited value in early diagnosis of periprosthetic joint infection (PJI). Here, we constructed a novel machine learning (ML)-derived,…”
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Application of the New Irrigation Protocol to Reduce Recurrence Rate in the Management Of Periprosthetic Joint Infection by Wu, Xiaoyu, Chen, Weishen, Rong, Rong, Pan, Baiqi, Hu, Xuantao, Zheng, Linli, Alimu, Aerman, Chu, Chenghan, Tu, Yucheng, Zhang, Ziji, Ye, Yongyu, Gu, Minghui, Sheng, Puyi

“…Objective Irrigation is a conventional treatment for acute and chronic periprosthetic joint infections (PJI). However, there has been no unified standard for…”
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Fluctuation of fasting blood glucose in patients who underwent primary or revision total joint arthroplasty: a retrospective review by Ye, Yongyu, Pan, Baiqi, Gu, Minghui, Xian, Guoyan, Chen, Weishen, Zheng, Linli, Zhang, Ziji, Sheng, Puyi

“…Abstract Background Perioperative hyperglycemia is a risk factor for postoperative complications after total joint arthroplasty (TJA). However, the variability…”
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Macrophages-derived exosomes modulates wear particle-induced osteolysis via miR-3470b targeting TAB3/NF-κB signaling by Pan, Baiqi, Zhang, Ziji, Wu, Xiaoyu, Xian, Guoyan, Hu, Xuantao, Gu, Minghui, Zheng, Linli, Li, Xiang, Long, Lingli, Chen, Weishen, Sheng, Puyi

“…Image 1 • Crosstalk between macrophages and osteoclasts/osteoblasts is crucial to induced osteolysis. • Uptake of macrophage-derived exosomes show greater…”
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Wear Particles Promote Reactive Oxygen Species-Mediated Inflammation via the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Pathway in Macrophages Surrounding Loosened Implants by Chen, Weishen, Li, Ziqing, Guo, Ying, Zhou, Yuhuan, Zhang, Ziji, Zhang, Yangchun, Luo, Guotian, Yang, Xing, Liao, Weiming, Li, Chaohong, Chen, Lingwu, Sheng, Puyi

“…Background/Aims: Prosthesis loosening is closely associated with chronic inflammatory cytokine secretion by macrophages, which are activated by wear particles…”
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MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation by Chen, Weishen, Chen, Lingwu, Zhang, Ziji, Meng, Fangang, Huang, Guangxin, Sheng, Puyi, Zhang, Zhiqi, Liao, Weiming

“…Histone acetylation regulated by class I histone deacetylases (HDACs) plays a pivotal role in matrix-specific gene transcription and cartilage development…”
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Effects of vitamin E-diffused highly cross-linked UHMWPE particles on inflammation, apoptosis and immune response against S. aureus by Chen, Weishen, Bichara, David A., Suhardi, Jeremy, Sheng, Puyi, Muratoglu, Orhun K.

“…Particle-induced osteolysis and periprosthetic joint infection (PJI) are closely associated with periprosthetic tissue immune function. The objective of this…”
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MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation by Mao, Guping, Zhang, Ziji, Huang, Zhiyu, Chen, Weishen, Huang, Guangxin, Meng, Fangang, Zhang, Zhiqi, Kang, Yan

“…Summary Objective Increased activity of histone deacetylase 2 (HDAC2) has been found in patients with osteoarthritis (OA) and cartilage matrix degradation and…”
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Titanium particles induce apoptosis by promoting autophagy in macrophages via the PI3K/Akt signaling pathway by Xian, Guoyan, Chen, Weishen, Gu, Minghui, Ye, Yongyu, Yang, Guangpu, Lai, Weiming, Xiao, Yinbo, Zhao, Xiaoyi, Zheng, Linli, Pan, Baiqi, Kang, Yunze, Zhang, Ziji, Sheng, Puyi

“…Chronic inflammation and infection in the tissue surrounding implants after total joint replacement is closely associated with the innate immune response to…”
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