Search Results - "Chen, Weihsu C"

Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169 by Chen, Weihsu C, Kawasaki, Norihito, Nycholat, Corwin M, Han, Shoufa, Pilotte, Julie, Crocker, Paul R, Paulson, James C

“…Sialoadhesin (Sn, Siglec-1, CD169) is a member of the sialic acid binding Ig-like lectin (siglec) family expressed on macrophages. Its macrophage specific…”
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Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies by Chen, Weihsu C, Murawsky, Christopher M

“…Therapeutic molecules derived from antibodies have become a dominant class of drugs used to treat human disease. Increasingly, therapeutic antibodies are…”
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A 17-gene stemness score for rapid determination of risk in acute leukaemia by Ng, Stanley W. K., Mitchell, Amanda, Kennedy, James A., Chen, Weihsu C., McLeod, Jessica, Ibrahimova, Narmin, Arruda, Andrea, Popescu, Andreea, Gupta, Vikas, Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., Bullinger, Lars, Herold, Tobias, Görlich, Dennis, Büchner, Thomas, Hiddemann, Wolfgang, Berdel, Wolfgang E., Wörmann, Bernhard, Cheok, Meyling, Preudhomme, Claude, Dombret, Hervé, Metzeler, Klaus, Buske, Christian, Löwenberg, Bob, Valk, Peter J. M., Zandstra, Peter W., Minden, Mark D., Dick, John E., Wang, Jean C. Y.

“…A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy…”
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Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms by Lee, JongBok, Minden, Mark D, Chen, Weihsu C, Streck, Elena, Chen, Branson, Kang, Hyeonjeong, Arruda, Andrea, Ly, Dalam, Der, Sandy D, Kang, Sohyeong, Achita, Paulina, D'Souza, Cheryl, Li, Yueyang, Childs, Richard W, Dick, John E, Zhang, Li

“…To explore the potential of expanded healthy donor-derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia…”
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In vivo targeting of B-cell lymphoma with glycan ligands of CD22 by Chen, Weihsu C., Completo, Gladys C., Sigal, Darren S., Crocker, Paul R., Saven, Alan, Paulson, James C.

“…Antibody-mediated cell depletion therapy has proven to provide significant clinical benefit in treatment of lymphomas and leukemias, driving the development of…”
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Noninvasive Imaging of Dendrimer‐Type N‐Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure by Tanaka, Katsunori, Siwu, Eric R.O, Minami, Kaori, Hasegawa, Koki, Nozaki, Satoshi, Kanayama, Yousuke, Koyama, Koichi, Chen, Weihsu C, Paulson, James C, Watanabe, Yasuyoshi, Fukase, Koichi

“…Body image: Self‐activating Huisgen 1,3‐dipolar cycloaddition and 6π azaelectrocyclization of lysine‐based dendrimers (see picture) enable the in vivo dynamics…”
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Targeting B lymphoma with nanoparticles bearing glycan ligands of CD22 by Chen, Weihsu C., Sigal, Darren S., Saven, Alan, Paulson, James C.

“…Abstract CD22 is a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family expressed on B cells that recognizes glycans of glycoproteins…”
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CellCelector™ as a platform in isolating primary B cells for antibody discovery by Matochko, Wadim L, Nelep, Constantin, Chen, Weihsu C, Grauer, Stephanie, McFadden, Karyn, Wilson, Vicki, Oxenoid, Kirill

“…ABSTRACT The most robust strategy in antibody discovery is the use of immunized animals and the ability to isolate and immortalize immune B-cells to hybridoma…”
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An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers by Chen, Weihsu C, Yuan, Julie S, Xing, Yan, Mitchell, Amanda, Mbong, Nathan, Popescu, Andreea C, McLeod, Jessica, Gerhard, Gitte, Kennedy, James A, Bogdanoski, Goce, Lauriault, Stevan, Perdu, Sofie, Merkulova, Yulia, Minden, Mark D, Hogge, Donna E, Guidos, Cynthia, Dick, John E, Wang, Jean C Y

“…Many promising new cancer drugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical testing. Thus, improved models…”
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Bryostatin-I: A dendritic cell stimulator for chemokines induction and a promising adjuvant for a peptide based cancer vaccine by Yan, Weili, Chen, Weihsu C., Liu, Ziming, Huang, Leaf

“…Bryostatin-1 (Bryo-1), a PKC modulator, was previously shown to activate monocytes and lymphocytes to produce cytokines. In this report, we investigated the…”
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Noninvasive Imaging of Dendrimer‐Type N‐Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure by Tanaka, Katsunori, Siwu, Eric R. O., Minami, Kaori, Hasegawa, Koki, Nozaki, Satoshi, Kanayama, Yousuke, Koyama, Koichi, Chen, Weihsu C., Paulson, James C., Watanabe, Yasuyoshi, Fukase, Koichi

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Abstract 4445: Selective inhibitor of nuclear exporter CRM1/XPO1, Selinexor (KPT-330), exhibits remarkable activity against AML leukemia-initiating cells while sparing normal hematopoietic cells by Etchin, Julia, Le, Bonnie Thi, Berezovskaya, Alla, Conway, Amy S., Chen, Weihsu C., Kentsis, Alex, Mansour, Marc R., Stone, Richard M., Galinsky, Ilene A., DeAngelo, Daniel J., McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Wang, Jean CY, Kung, Andrew L., Look, Thomas

“…Current treatments for acute myeloid leukemia (AML) often fail to induce long-term remissions and are toxic to normal tissues, prompting the need to develop…”
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Abstract 907: Efficacy of SAR302503, a JAK2 inhibitor, in primary human acute myeloid leukemia xenografts by Chen, Weihsu C., Popescu, Andreea C., Xing, Yan, Gerhard, Gitte, Yuan, Julie, Minden, Mark, Guidos, Cynthia, Hogge, Donna E., Dick, John E., Wang, Jean CY

“…Small molecule inhibitors of Janus kinase 2 (JAK2) such as Ruxolitinib and SAR302503 have demonstrated efficacy in clinical trials for treatment of…”
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Noninvasive Imaging of Dendrimer-Type N-Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure by Tanaka, Katsunori, Siwu, Eric R. O., Minami, Kaori, Hasegawa, Koki, Nozaki, Satoshi, Kanayama, Yousuke, Koyama, Koichi, Chen, Weihsu C., Paulson, James C., Watanabe, Yasuyoshi, Fukase, Koichi

“…Ganzkörperaufnahme: Eine selbstaktivierende 1,3‐dipolare Huisgen‐Cycloaddition und eine 6π‐Azaelektrocyclisierung von Lysin‐haltigen Dendrimeren (siehe Bild)…”
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