Search Results - "Chen, Tricia"
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Epitope screening using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX‐MS): An accelerated workflow for evaluation of lead monoclonal antibodies
Published in Biotechnology journal (01-02-2022)“…Background Epitope mapping is an increasingly important aspect of biotherapeutic and vaccine development. Recent advances in therapeutic antibody design and…”
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Genome-wide screen of three herpesviruses for protein subcellular localization and alteration of PML nuclear bodies
Published in PLoS pathogens (01-07-2008)“…Herpesviruses are large, ubiquitous DNA viruses with complex host interactions, yet many of the proteins encoded by these viruses have not been functionally…”
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Journal Article -
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Epitope Profiling of Diphtheria Toxoid Provides Enhanced Monitoring for Consistency Testing during Manufacturing Process Changes
Published in Vaccines (Basel) (13-05-2022)“…In the vaccine industry, multiple physicochemical, immunological, and analytical methods are applied throughout the manufacturing process to characterize and…”
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4
Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines
Published in Vaccines (Basel) (27-01-2023)“…There is increasing interest to replace animal-based potency assays used routinely to test vaccines, since they are highly variable, are costly, and present…”
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5
Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function
Published in Virology (New York, N.Y.) (25-05-2009)“…Abstract The Rev protein of HIV-1 is essential for HIV-1 proliferation due to its role in exporting viral RNA from the nucleus. We used a modified version of…”
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Characterization of the Interaction between P143 and LEF-3 from Two Different Baculovirus Species: Choristoneura fumiferana Nucleopolyhedrovirus LEF-3 Can Complement Autographa californica Nucleopolyhedrovirus LEF-3 in Supporting DNA Replication
Published in Journal of Virology (01-01-2004)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hydrogen–Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin
Published in Biochemistry (Easton) (12-02-2019)“…The diphtheria toxoid (DT) antigen is one of the major components in pediatric and booster combination vaccines and is known to raise a protective humoral…”
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Flow cytometry: An efficient method for antigenicity measurement and particle characterization on an adjuvanted vaccine candidate H4-IC31 for tuberculosis
Published in Journal of immunological methods (01-01-2018)“…We have developed an accurate, precise and stability-indicating flow cytometry (FC) based assay to directly measure antigenicity of H4 protein (also known as…”
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Journal Article -
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Genome-Wide Screen of Three Herpesviruses for Protein Subcellular Localization and Alteration of PML Nuclear Bodies: e1000100
Published in PLoS pathogens (01-07-2008)“…Herpesviruses are large, ubiquitous DNA viruses with complex host interactions, yet many of the proteins encoded by these viruses have not been functionally…”
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Journal Article -
10
Expression Profiling of Herpesvirus and Vaccinia Virus Proteins Using a High-Throughput Baculovirus Screening System
Published in Journal of proteome research (01-11-2005)“…We have developed a high-throughput system for generating baculoviruses and testing the expression, solubility, and affinity column purification of encoded…”
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Journal Article -
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Characterization of the interaction between baculovirus P143 and LEF-3 proteins: Potential role in baculovirus species specificity
Published 01-01-2002“…P143 functions as a helicase in baculovirus DNA replication. This implies that P143 localizes to the nucleus of the cell. Nuclear localization of P143 requires…”
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Dissertation