Search Results - "Chen, Tongke"

Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells by Lin, Xiaokun, Han, Lei, Weng, Jialei, Wang, Kelai, Chen, Tongke

“…To investigate the effect of Rapamycin on proliferation and autophagy in human neuroblastoma (NB) cell lines and to elucidate the possible mechanism. NB cells…”
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Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer by Wang, Lihua, Wang, Canwei, Tao, Zheying, Zhao, Liqian, Zhu, Zheng, Wu, Wencan, He, Ye, Chen, Hong, Zheng, Bin, Huang, Xiangjie, Yu, Yun, Yang, Linjun, Liang, Guang, Cui, Ri, Chen, Tongke

“…Breast cancer is the most prevalent cancer among women worldwide. WZ35, an analog of curcumin, has been demonstrated to remarkably improve the pharmacokinetic…”
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SRSF3 and HNRNPH1 Regulate Radiation-Induced Alternative Splicing of Protein Arginine Methyltransferase 5 in Hepatocellular Carcinoma by Wen, Chaowei, Tian, Zhujun, Li, Lan, Chen, Tongke, Chen, Huajian, Dai, Jichen, Liang, Zhenzhen, Ma, Shumei, Liu, Xiaodong

“…Protein arginine methyltransferase 5 (PRMT5) is an epigenetic regulator which has been proven to be a potential target for cancer therapy. We observed that…”
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Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics by Wang, Lihua, Chen, Xiwen, Du, Zhuanyun, Li, Gefei, Chen, Mayun, Chen, Xi, Liang, Guang, Chen, Tongke

“…Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various tumor types. Previous work has demonstrated that curcumin…”
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Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy by Zhang, Yikui, Li, Mengyun, Yu, Bo, Lu, Shengjian, Zhang, Lujie, Zhu, Senmiao, Yu, Zhonghao, Xia, Tian, Huang, Haoliang, Jiang, WenHao, Zhang, Si, Sun, Lanfang, Ye, Qian, Sun, Jiaying, Zhu, Hui, Huang, Pingping, Hong, Huifeng, Yu, Shuaishuai, Li, Wenjie, Ai, Danni, Fan, Jingfan, Li, Wentao, Song, Hong, Xu, Lei, Chen, Xiwen, Chen, Tongke, Zhou, Meng, Ou, Jingxing, Yang, Jian, Li, Wei, Hu, Yang, Wu, Wencan

“…Therapeutic hypothermia (TH) is potentially an important therapy for central nervous system (CNS) trauma. However, its clinical application remains…”
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A novel small molecule glycolysis inhibitor WZ35 exerts anti-cancer effect via metabolic reprogramming by Wang, Lihua, Zhu, Zheng, Liang, Qi, Tao, Yecheng, Jin, Gaowei, Zhong, Yaoyao, Dai, Jichen, Dai, Ruixia, Wang, Zhixiang, Chen, Junbo, Zhou, Lingjie, Ke, Shouyu, Zheng, Bin, Lan, Linhua, Lin, Xiaokun, Chen, Tongke

“…Liver cancer is the fifth leading cause of cancer death worldwide, but early diagnosis and treatment of liver cancer remains a clinical challenge. How to…”
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EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells by Zou, Peng, Xia, Yiqun, Chen, Weiqian, Chen, Xi, Ying, Shilong, Feng, Zhiguo, Chen, Tongke, Ye, Qingqing, Wang, Zhe, Qiu, Chenyu, Yang, Shulin, Liang, Guang

“…Gastric cancer (GC) is one of the leading causes of cancer mortality in the world, and finding novel agents for the treatment of advanced gastric cancer is of…”
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Identification of three metabolic subtypes in gastric cancer and the construction of a metabolic pathway-based risk model that predicts the overall survival of GC patients by Chen, Tongzuan, Zhao, Liqian, Chen, Junbo, Jin, Gaowei, Huang, Qianying, Zhu, Ming, Dai, Ruixia, Yuan, Zhengxi, Chen, Junshuo, Tang, Mosheng, Chen, Tongke, Lin, Xiaokun, Ai, Weiming, Wu, Liang, Chen, Xiangjian, Qin, Le

“…Gastric cancer (GC) is highly heterogeneous and GC patients have low overall survival rates. It is also challenging to predict the prognosis of GC patients…”
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Preparation of curcumin micelles and the in vitro and in vivo evaluation for cancer therapy by Li, Xingyi, Chen, Tongke, Xu, Lu, Zhang, Zhaoliang, Li, Lingli, Chen, Hao

“…Poor water solubility as well as poor bioavailability of curcumin has greatly hindered its applications in cancer therapy. In the present study, a highly water…”
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LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function by Li, Yujie, Huang, Dawei, Jia, Lianqun, Shangguan, Fugen, Gong, Shiwei, Lan, Linhua, Song, Zhiyin, Xu, Juan, Yan, Chaojun, Chen, Tongke, Tan, Yin, Liu, Yongzhang, Huang, Xingxu, Suzuki, Carolyn K, Yang, Zhongzhou, Yang, Guanlin, Lu, Bin

“…Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and homeostasis. In particular, the…”
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The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway by Chen, Tongke, Zhao, Liqian, Chen, Shinuo, Zheng, Bin, Chen, Hong, Zeng, Tianni, Sun, Hanxiao, Zhong, Sijia, Wu, Wencan, Lin, Xiaokun, Wang, Lihua

“…To investigate the anti-tumor activities of WZ35 and its possible molecular mechanism, bioinformatics analysis and the hematoxylin-eosin (HE) staining were…”
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Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions by Huang, Huimin, Wang, Shitong, Xia, Hongping, Zhao, Xingling, Chen, Kaiyuan, Jin, Guihua, Zhou, Shipeng, Lu, Zhaoliang, Chen, Tongke, Yu, Huajun, Zheng, Xiaoqun, Huang, Haishan, Lan, Linhua

“…The aim of this study was to investigate the underlying molecular mechanism behind the promotion of cell survival under conditions of glucose deprivation by…”
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WZ35 inhibits gastric cancer cell metastasis by depleting glutathione to promote cellular metabolic remodeling by Chen, Tongke, Chen, Junbo, Zeng, Tianni, Huang, Qianying, Chen, Di, Chen, Hong, Chen, Jiayao, Zheng, Bin, Wang, Mengting, Chen, Shinuo, Dai, Jichen, Sun, Hanxiao, Chen, Tongzuan, Huang, Yuwen, Zhao, Liqian, Ma, Shumei, Liu, Xiaodong

“…This study aimed at elucidating the crosstalk between redox reaction and metabolic remodeling through uncovering the mechanism underlying WZ35-mediated…”
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A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growth via downregulating YAP-mediated autophagy by Wang, Lihua, Zhu, Zheng, Han, Lei, Zhao, Liqian, Weng, Jialei, Yang, Hongbao, Wu, Shijia, Chen, Kaiyuan, Wu, Liang, Chen, Tongke

“…Hepatocellular carcinoma (HCC) is a common cancer type throughout the world. Due to the high occurrence rate and mortality, liver cancer is one of the leading…”
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Selective killing of gastric cancer cells by a small molecule targeting ROS-mediated ER stress activation by Zou, Peng, Xia, Yiqun, Chen, Tongke, Zhang, Junru, Wang, Zhe, Chen, Wenbo, Chen, Minxiao, Kanchana, Karvannan, Yang, Shulin, Liang, Guang

“…Gastric cancer is one of the leading causes of cancer mortality in the world. Curcumin is a natural product with multiple pharmacological activities, while its…”
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Curcumin micelles suppress gastric tumor cell growth by upregulating ROS generation, disrupting redox equilibrium and affecting mitochondrial bioenergetics by Lin, Xiaokun, Wang, Lihua, Zhao, Liqian, Zhu, Zheng, Chen, TongZuan, Chen, Shinuo, Tao, Yecheng, Zeng, Tianni, Zhong, Yaoyao, Sun, Hanxiao, Wang, Zhixiang, Zheng, Weisheng, Zhang, Yuhao, Wu, Wencan, Nan, Kaihui, Chen, Tongke

“…Gastric cancer is the fourth most common cancer and the second most frequent cause of cancer death worldwide. Chemotherapy is an important treatment. However,…”
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Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patients by Chen, Xiao, Li, Wen-Feng, Wu, Xiaoli, Zhang, Heng-Chao, Chen, Li, Zhang, Pei-Ying, Liu, Li-Yuan, Ma, Di, Chen, Tongke, Zhou, Lingli, Xu, Yunsheng, Zhou, Meng-Tao, Tang, Kai-Fu

“…DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by…”
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The curcumin derivative WZ35 activates ROS-dependent JNK to suppress hepatocellular carcinoma metastasis by Wang, Lihua, Han, Lijie, Tao, Zheying, Zhu, Zheng, Han, Lei, Yang, Zhenfei, Wang, Hao, Dai, Dandan, Wu, Liang, Yuan, Zhengzhong, Chen, Tongke

“…Tumor metastasis is the leading cause of cancer death; due to the progress made in the elucidation of the mechanism of cancer cell metastasis, there is hope…”
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Mechanisms Underlying Therapeutic Effects Of Traditional Chinese Medicine On Gastric Cancer by Yang, Linjun, Zhao, Liqian, Zeng, Tianni, Chen, Hong, Shao, Jingjing, Yang, Song, Tao, Zheying, Yang, Jingqin, Chen, Tongke, Lin, Xiaokun, Chen, Xiwen, Tang, Mosheng

“…Gastric cancer (GC) is one of the most common malignant tumors in the world. It is the fourth most common cancer and has the second highest mortality rate…”
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