Search Results - "Chen, Tiffany F."

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic by Zhang, Xuqing, Luo, Mengyao, Dastagir, Shamael R., Nixon, Mellissa, Khamhoung, Annie, Schmidt, Andrea, Lee, Albert, Subbiah, Naren, McLaughlin, Douglas C., Moore, Christopher L., Gribble, Mary, Bayhi, Nicholas, Amin, Viral, Pepi, Ryan, Pawar, Sneha, Lyford, Timothy J., Soman, Vikram, Mellen, Jennifer, Carpenter, Christopher L., Turka, Laurence A., Wickham, Thomas J., Chen, Tiffany F.

“…Checkpoint inhibitors and T-cell therapies have highlighted the critical role of T cells in anti-cancer immunity. However, limitations associated with these…”
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Role of Dimerization in the Catalytic Properties of the Escherichia coli Disulfide Isomerase DsbC by Arredondo, Silvia A., Chen, Tiffany F., Riggs, Austen F., Gilbert, Hiram F., Georgiou, George

“…The bacterial protein-disulfide isomerase DsbC is a homodimeric V-shaped enzyme that consists of a dimerization domain, two α-helical linkers, and two opposing…”
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Artificial Anti-Tumor Opsonizing Proteins with Fibronectin Scaffolds Engineered for Specificity to Each of the Murine FcγR Types by Chen, Tiffany F., Li, Kevin K., Zhu, Eric F., Opel, Cary F., Kauke, Monique J., Kim, Heeyoon, Atolia, Eta, Wittrup, K. Dane

“…We have engineered a panel of novel Fn3 scaffold-based proteins that bind with high specificity and affinity to each of the individual mouse Fcγ receptors…”
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Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs by Chen, Tiffany F., Sazinsky, Stephen L., Houde, Damian, DiLillo, David J., Bird, Julie, Li, Kevin K., Cheng, George T., Qiu, Huawei, Engen, John R., Ravetch, Jeffrey V., Wittrup, K. Dane

“…The binding of human IgG1 to human Fc gamma receptors (hFcγRs) is highly sensitive to the presence of a single N-linked glycosylation site at asparagine 297 of…”
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Triepitopic Antibody Fusions Inhibit Cetuximab-Resistant BRAF and KRAS Mutant Tumors via EGFR Signal Repression by Spangler, Jamie B., Manzari, Mandana T., Rosalia, Elizabeth K., Chen, Tiffany F., Wittrup, K. Dane

“…Dysregulation of epidermal growth factor receptor (EGFR) is a hallmark of many epithelial cancers, rendering this receptor an attractive target for cancer…”
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GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes by Uenishi, Gene I, Repic, Marko, Yam, Jennifer Y, Landuyt, Ashley, Saikumar-Lakshmi, Priya, Guo, Tingxi, Zarin, Payam, Sassone-Corsi, Martina, Chicoine, Adam, Kellogg, Hunter, Hunt, Martina, Drow, Travis, Tewari, Ritika, Cook, Peter J, Yang, Soo Jung, Cerosaletti, Karen, Schweinoch, Darius, Guiastrennec, Benjamin, James, Eddie, Patel, Chandra, Chen, Tiffany F, Buckner, Jane H, Rawlings, David J, Wickham, Thomas J, Mueller, Karen T

“…Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserving β cell function…”
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Engineering New Protein-Protein Interactions on the β-Propeller Fold by Yeast Cell Surface Display by Zhang, Keya, Li, Heng, Bhuripanyo, Karan, Zhao, Bo, Chen, Tiffany F., Zheng, Ning, Yin, Jun

“…Reinventing the wheel: The β‐propeller domain folds like a wheel to provide key protein–protein interactions in the cell. Here we used high‐throughput yeast…”
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Protein Engineering and Selection Using Yeast Surface Display by Angelini, Alessandro, Chen, Tiffany F, de Picciotto, Seymour, Yang, Nicole J, Tzeng, Alice, Santos, Michael S, Van Deventer, James A, Traxlmayr, Michael W, Wittrup, K Dane

“…Yeast surface display is a powerful technology for engineering a broad range of protein scaffolds. This protocol describes the process for de novo isolation of…”
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Engineering fibronectin-based binding proteins by yeast surface display by Chen, Tiffany F, de Picciotto, Seymour, Hackel, Benjamin J, Wittrup, K Dane

“…Yeast surface display (YSD) presents proteins on the surface of yeast through interaction of the agglutinin subunits Aga1p and Aga2p. The human 10th type III…”
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Abstract 3260: Engineered red-cell therapeutics (RCT) as artificial antigen presenting cells promote in vivo expansion and anti-tumor activity of antigen specific T cells by Zhang, Xuqing, Dastagir, Shamael R., Subbiah, Naren, Luo, Mengyao, Soman, Vikram, Pawar, Sneha, McLaughlin, Douglas C., Bayhi, Nicholas, Amin, Viral, Nissen, Torben Straight, Carpenter, Christopher L., Wickham, Thomas J., Chen, Tiffany F.

“…T cell-based therapies have demonstrated efficacy in a small subset of cancers; however, they have the potential to proliferate uncontrollably and…”
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Abstract B062: Enabling the rapid generation of allogeneic artificial antigen presenting cell (aAPC) Red Cell Therapeutics with a loadable MHC system by Moore, Christopher L, Pawar, Sneha, Nixon, Mellissa, Lyford, Timothy J, McLaughlin, Douglas C, Dastagir, Shamael R, Bracha, Abigail, Melancon, Lori, Carpenter, Christopher L, Wickham, Thomas J, Chen, Tiffany F

“…Next generation sequencing technologies, coupled with personal neoantigen identification approaches, have significantly improved the capability to develop…”
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Abstract 1250: Fibronectin domains engineered for specificity to individual murine Fc gamma receptors modulate tumoricidal activity of immune cells by Chen, Tiffany F., Li, Kevin, Wittrup, K. Dane

“…Activating and inhibitory Fc gamma receptors (FcγRs) can play a large role in the efficacy of certain antibody therapeutics. The Fc regions of the antibody…”
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Engineering New Protein-Protein Interactions on the [beta]-Propeller Fold by Yeast Cell Surface Display by Zhang, Keya, Li, Heng, Bhuripanyo, Karan, Zhao, Bo, Chen, Tiffany F, Zheng, Ning, Yin, Jun

“…REINVENTING THE WHEEL: The [beta]-propeller domain folds like a wheel to provide key protein-protein interactions in the cell. Here we used high-throughput…”
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The roles of lumbar load thresholds in cumulative lifting exposure to predict disk protrusion in an Asian population by Hung, Isabella Y-J, Shih, Tiffany T-F, Chen, Bang-Bin, Liou, Saou-Hsing, Ho, Ing-Kang, Guo, Yue Leon

“…The purpose of this study was to determine whether a specific threshold per lifting movement, the accumulation above which best predicts lumbar disk…”
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