Search Results - "Chen, Tenghui"

Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations by Dogruluk, Turgut, Tsang, Yiu Huen, Espitia, Maribel, Chen, Fengju, Chen, Tenghui, Chong, Zechen, Appadurai, Vivek, Dogruluk, Armel, Eterovic, Agna Karina, Bonnen, Penelope E, Creighton, Chad J, Chen, Ken, Mills, Gordon B, Scott, Kenneth L

“…Large-scale sequencing efforts are uncovering the complexity of cancer genomes, which are composed of causal "driver" mutations that promote tumor progression…”
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High-peak-power and wavelength tunable acousto-optic Q-switched Er:ZBLAN fiber laser by Chen, Tenghui, Yao, Weichao, Uehara, Hiyori, Ma, Chunyang, Sohail, Muhammad, Zhang, Chunxiang, Ge, Yanqi, Fan, Dianyuan, Liu, Jun

“…Abstract We demonstrate Q-switching operation of a single-moded mid-infraredEr 3+ -doped ZBLAN (Er:ZBLAN) fiber laser based on an acousto-optic modulator. The…”
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Cancer driver mutation prediction through Bayesian integration of multi-omic data by Wang, Zixing, Ng, Kwok-Shing, Chen, Tenghui, Kim, Tae-Beom, Wang, Fang, Shaw, Kenna, Scott, Kenneth L, Meric-Bernstam, Funda, Mills, Gordon B, Chen, Ken

“…Identification of cancer driver mutations is critical for advancing cancer research and personalized medicine. Due to inter-tumor genetic heterogeneity, many…”
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ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis by Liu, Jian, Cho, Sung-Nam, Akkanti, Bindu, Jin, Nili, Mao, Jianqiang, Long, Weiwen, Chen, Tenghui, Zhang, Yiqun, Tang, Ximing, Wistub, Ignacio I., Creighton, Chad J., Kheradmand, Farrah, DeMayo, Francesco J.

“…Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with squamous cell carcinoma has identified SMAD4 to be…”
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Bias from removing read duplication in ultra-deep sequencing experiments by Zhou, Wanding, Chen, Tenghui, Zhao, Hao, Eterovic, Agda Karina, Meric-Bernstam, Funda, Mills, Gordon B, Chen, Ken

“…Identifying subclonal mutations and their implications requires accurate estimation of mutant allele fractions from possibly duplicated sequencing reads…”
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Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the of TRAF6 Polyubiquitination by Chen, Qiang, Chen, Tenghui, Li, Wenjiao, Zhang, Wei, Zhu, Jingwei, Li, Yang, Huang, Yaojian, Shen, Yuemao, Yu, Chundong

“…Mycoepoxydiene (MED) is a polyketide isolated from a marine fungus associated with mangrove forests. MED has been shown to be able to induce cell cycle arrest…”
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Steroid receptor coactivator 3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis by Chen, Qiang, Chen, Tenghui, Xu, Yixiang, Zhu, Jingwei, Jiang, Yuan, Zhao, Yang, Xu, Jianming, Yu, Chundong

“…Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in regulation of bacterial LPS-induced inflammation. However,…”
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SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism by Chen, Tenghui, Chen, Qiang, Xu, Yixiang, Zhou, Qiling, Zhu, Jingwei, Zhang, Hao, Wu, Qiao, Xu, Jianming, Yu, Chundong

“…Background & Aims Nuclear receptors such as pregnane X receptor and constitutive androstane receptor (CAR) are important regulators of drug-metabolizing…”
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Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy by Gao, Jianjun, Shi, Lewis Zhichang, Zhao, Hao, Chen, Jianfeng, Xiong, Liangwen, He, Qiuming, Chen, Tenghui, Roszik, Jason, Bernatchez, Chantale, Woodman, Scott E., Chen, Pei-Ling, Hwu, Patrick, Allison, James P., Futreal, Andrew, Wargo, Jennifer A., Sharma, Padmanee

“…Antibody blockade of the inhibitory CTLA-4 pathway has led to clinical benefit in a subset of patients with metastatic melanoma. Anti-CTLA-4 enhances T cell…”
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Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction by Liu, Xindong, Wang, Yun, Lu, Huiping, Li, Jing, Yan, Xiaowei, Xiao, Minglu, Hao, Jing, Alekseev, Andrei, Khong, Hiep, Chen, Tenghui, Huang, Rui, Wu, Jin, Zhao, Qiwen, Wu, Qi, Xu, Senlin, Wang, Xiaohu, Jin, Wei, Yu, Shicang, Wang, Yan, Wei, Lai, Wang, Aibo, Zhong, Bo, Ni, Ling, Liu, Xiaolong, Nurieva, Roza, Ye, Lilin, Tian, Qiang, Bian, Xiu-Wu, Dong, Chen

“…T cells become dysfunctional when they encounter self antigens or are exposed to chronic infection or to the tumour microenvironment 1 . The function of T…”
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Abstract P110: Neandertal introgressions contribute to upper aero-digestive tract tumor patient survival and identify patients who may benefit from STING agonist treatment by Gualberto, Antonio, Chen, Tenghui, Scholz, Catherine, Luke, Jason

“…Abstract Background: Admixture of archaic (Neandertal and Denisova) and ancestral genes enhanced natural immunity during out of Africa migrations and modulates…”
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Correction: Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the Suppression of TRAF6 Polyubiquitination by Chen, Qiang, Chen, Tenghui, Li, Wenjiao, Zhang, Wei, Zhu, Jingwei, Yang, Li, Huang, Yaojian, Shen, Yuemao, Yu, Chundong

“…Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the Suppression of TRAF6 Polyubiquitination. (2012) Mycoepoxydiene Inhibits…”
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Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the suppression of TRAF6 polyubiquitination [corrected] by Chen, Qiang, Chen, Tenghui, Li, Wenjiao, Zhang, Wei, Zhu, Jingwei, Li, Yang, Huang, Yaojian, Shen, Yuemao, Yu, Chundong

“…Mycoepoxydiene (MED) is a polyketide isolated from a marine fungus associated with mangrove forests. MED has been shown to be able to induce cell cycle arrest…”
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novoBreak: local assembly for breakpoint detection in cancer genomes by Chong, Zechen, Ruan, Jue, Gao, Min, Zhou, Wanding, Chen, Tenghui, Fan, Xian, Ding, Li, Lee, Anna Y, Boutros, Paul, Chen, Junjie, Chen, Ken

“…The novoBreak software provides sensitive, accurate, and comprehensive detection of structural variation in somatic next-generation sequencing data. We present…”
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Two-dimensional gold decorated indium selenide for near-infrared and mid-infrared ultrafast photonics by He, Zhenwu, Li, Zhongjun, Wang, Zhenhong, Zhang, Chunxiang, Chen, Tenghui, Zhao, Ting, Xu, Changwen, Zhang, Yuan, Liu, Jun

“…•Decorated with gold nanoparticles, Indium selenide nanosheets exhibits excellent nonlinear absorption properties.•It is the shortest mode-locking pulse…”
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The shape memory effect of crosslinked ultra-high-molecular-weight polyethylene prepared by silane-induced crosslinking method by Chen, Tenghui, Li, Qiuying, Fu, Zhiwei, Sun, Lewen, Guo, Weihong, Wu, Chifei

“…Crosslinked ultra-high-molecular-weight polyethylene (UHMWPE) with excellent shape memory properties was prepared from the silane-grafted UHMWPE mixed with…”
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Carbon nanoparticles (CNPs) as a saturable absorber for a passively Q-switched erbium (Er3+) doped fiber laser by Sohail, Muhammad, Zhang, Chunxiang, Ahmed, Rizwan, Asghar, Haroon, Ali Khan, Sayed, Zamin Khan, Noor, Chen, Tenghui, Aslam. Baig, M., Wang, Zhenhong

“…•The CNPs are synthesized from candle soot by using a simple deposition technique were proposed.•The nonlinearity of the CNPs was measured through the twin…”
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TransVar: a multilevel variant annotator for precision genomics by Zhou, Wanding, Chen, Tenghui, Chong, Zechen, Rohrdanz, Mary A, Melott, James M, Wakefield, Chris, Zeng, Jia, Weinstein, John N, Meric-Bernstam, Funda, Mills, Gordon B, Chen, Ken

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Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types by Chen, Tenghui, Wang, Zixing, Zhou, Wanding, Chong, Zechen, Meric-Bernstam, Funda, Mills, Gordon B, Chen, Ken

“…An important step towards personalizing cancer treatment is to integrate heterogeneous evidences to catalog mutational hotspots that are biologically and…”
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Clinical actionability enhanced through deep targeted sequencing of solid tumors by Chen, Ken, Meric-Bernstam, Funda, Zhao, Hao, Zhang, Qingxiu, Ezzeddine, Nader, Tang, Lin-Ya, Qi, Yuan, Mao, Yong, Chen, Tenghui, Chong, Zechen, Zhou, Wanding, Zheng, Xiaofeng, Johnson, Amber, Aldape, Kenneth D, Routbort, Mark J, Luthra, Rajyalakshmi, Kopetz, Scott, Davies, Michael A, de Groot, John, Moulder, Stacy, Vinod, Ravi, Farhangfar, Carol J, Shaw, Kenna Mills, Mendelsohn, John, Mills, Gordon B, Eterovic, Agda Karina

“…Further advances of targeted cancer therapy require comprehensive in-depth profiling of somatic mutations that are present in subpopulations of tumor cells in…”
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