Search Results - "Chen, Steven J."

Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus by Ou, Li, Chen, Steven J, Teng, I-Ting, Yang, Lijuan, Zhang, Baoshan, Zhou, Tongqing, Biju, Andrea, Cheng, Cheng, Kong, Wing-Pui, Morano, Nicholas C, Stancofski, Erik-Stephane D, Todd, John-Paul, Tsybovsky, Yaroslav, Wang, Shuishu, Zheng, Cheng-Yan, Mascola, John R, Shapiro, Lawrence, Woodward, Ruth A, Buchholz, Ursula J, Kwong, Peter D

“…The Pneumoviridae family of viruses includes human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). The closely related Paramyxoviridae family…”
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Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability by Gorman, Jason, Cheung, Crystal Sao-Fong, Duan, Zhijian, Ou, Li, Wang, Maple, Chen, Xuejun, Cheng, Cheng, Biju, Andrea, Sun, Yaping, Wang, Pengfei, Yang, Yongping, Zhang, Baoshan, Boyington, Jeffrey C., Bylund, Tatsiana, Charaf, Sam, Chen, Steven J., Du, Haijuan, Henry, Amy R., Liu, Tracy, Sarfo, Edward K., Schramm, Chaim A., Shen, Chen-Hsiang, Stephens, Tyler, Teng, I-Ting, Todd, John-Paul, Tsybovsky, Yaroslav, Verardi, Raffaello, Wang, Danyi, Wang, Shuishu, Wang, Zhantong, Zheng, Cheng-Yan, Zhou, Tongqing, Douek, Daniel C., Mascola, John R., Ho, David D., Ho, Mitchell, Kwong, Peter D.

“…Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West Africa, posing a pandemic biothreat. LASV-neutralizing antibodies,…”
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Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base by Corrigan, Angela R., Duan, Hongying, Cheng, Cheng, Gonelli, Christopher A., Ou, Li, Xu, Kai, DeMouth, Megan E., Geng, Hui, Narpala, Sandeep, O’Connell, Sarah, Zhang, Baoshan, Zhou, Tongqing, Basappa, Manjula, Boyington, Jeffrey C., Chen, Steven J., O’Dell, Sijy, Pegu, Amarendra, Stephens, Tyler, Tsybovsky, Yaroslav, van Schooten, Jelle, Todd, John P., Wang, Shuishu, Doria-Rose, Nicole A., Foulds, Kathryn E., Koup, Richard A., McDermott, Adrian B., van Gils, Marit J., Kwong, Peter D., Mascola, John R.

“…Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free…”
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Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria by Francica, Joseph R, Shi, Wei, Chuang, Gwo-Yu, Chen, Steven J, Da Silva Pereira, Lais, Farney, S Katie, Flynn, Barbara J, Ou, Li, Stephens, Tyler, Tsybovsky, Yaroslav, Wang, Lawrence T, Anderson, Alexander, Beck, Zoltan, Dillon, Marlon, Idris, Azza H, Hurlburt, Nicholas, Liu, Tracy, Zhang, Baoshan, Alving, Carl R, Matyas, Gary R, Pancera, Marie, Mascola, John R, Kwong, Peter D, Seder, Robert A

“…The most advanced malaria vaccine, RTS,S, includes the central repeat and C-terminal domains of the circumsporozoite protein (PfCSP). We have recently isolated…”
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Assessment of Crosslinkers between Peptide Antigen and Carrier Protein for Fusion Peptide-Directed Vaccines against HIV-1 by Ou, Li, Gulla, Krishana, Biju, Andrea, Biner, Daniel W, Bylund, Tatsiana, Changela, Anita, Chen, Steven J, Zheng, Cheng-Yan, Cibelli, Nicole, Corrigan, Angela R, Duan, Hongying, Gonelli, Christopher A, Kong, Wing-Pui, Cheng, Cheng, O’Dell, Sijy, Sarfo, Edward K, Shaddeau, Andrew, Wang, Shuishu, Vinitsky, Alison, Yang, Yanhong, Zhang, Baoshan, Zhang, Yaqiu, Koup, Richard A, Doria-Rose, Nicole A, Gall, Jason G, Mascola, John R, Kwong, Peter D

“…Conjugate-vaccine immunogens require three components: a carrier protein, an antigen, and a crosslinker, capable of coupling antigen to carrier protein, while…”
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SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity by Olia, Adam S., Tsybovsky, Yaroslav, Chen, Steven J., Liu, Cuiping, Nazzari, Alexandra F., Ou, Li, Wang, Lingshu, Kong, Wing-Pui, Leung, Kwan, Liu, Tracy, Stephens, Tyler, Teng, I-Ting, Wang, Shuishu, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Zhou, Tongqing, Mascola, John R., Kwong, Peter D.

“…The SARS-CoV-2 spike is the primary target of virus-neutralizing antibodies and critical to the development of effective vaccines against COVID-19. Here, we…”
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Cholesterol reduction by immunization with a PCSK9 mimic by Zhang, Baoshan, Chuang, Gwo-Yu, Biju, Andrea, Biner, Daniel, Cheng, Jiaxuan, Wang, Yiran, Bao, Saran, Chao, Cara W., Lei, Haotian, Liu, Tracy, Nazzari, Alexandra F., Yang, Yongping, Zhou, Tongqing, Chen, Steven J., Chen, Xuejun, Kong, Wing-Pui, Ou, Li, Parchment, Danealle K., Sarfo, Edward K., SiMa, HaoMin, Todd, John-Paul, Wang, Shuishu, Woodward, Ruth A., Cheng, Cheng, Rawi, Reda, Mascola, John R., Kwong, Peter D.

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a plasma protein that controls cholesterol homeostasis. Here, we design a human PCSK9 mimic, named…”
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Electric dipole moments and interionic structure of para-substituted N-alkyl-N,N-dimethylanilinium benzenesulfonate ion pairs by Dominey, Lawrence A, Comeford, Lorrie, Chen, Steven J. H, Grunwald, Ernest

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