Search Results - "Chen, Shih Jen"

Efficacy and Safety of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy: Two-Year Results of the Aflibercept in Polypoidal Choroidal Vasculopathy Study by Wong, Tien Yin, Ogura, Yuichiro, Lee, Won Ki, Iida, Tomohiro, Chen, Shih-Jen, Mitchell, Paul, Gemmy Cheung, Chui Ming, Zhang, Zhongqi, Leal, Sérgio, Ishibashi, Tatsuro

“…We sought to evaluate longer-term efficacy and safety of intravitreal aflibercept monotherapy (IAI) vs IAI plus rescue photodynamic therapy (rPDT) in patients…”
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An Update on Gene Therapy for Inherited Retinal Dystrophy: Experience in Leber Congenital Amaurosis Clinical Trials by Chiu, Wei, Lin, Ting-Yi, Chang, Yun-Chia, Isahwan-Ahmad Mulyadi Lai, Henkie, Lin, Shen-Che, Ma, Chun, Yarmishyn, Aliaksandr A, Lin, Shiuan-Chen, Chang, Kao-Jung, Chou, Yu-Bai, Hsu, Chih-Chien, Lin, Tai-Chi, Chen, Shih-Jen, Chien, Yueh, Yang, Yi-Ping, Hwang, De-Kuang

“…Inherited retinal dystrophies (IRDs) are a group of rare eye diseases caused by gene mutations that result in the degradation of cone and rod photoreceptors or…”
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Point-of-Care Detection Devices for Food Safety Monitoring: Proactive Disease Prevention by Wu, Marie Yung-Chen, Hsu, Min-Yen, Chen, Shih-Jen, Hwang, De-Kuang, Yen, Tzung-Hai, Cheng, Chao-Min

“…Food safety has become an increasingly significant public concern in both developed and under-developed nations around the world; it increases morbidity,…”
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An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine by Rastegari, Elham, Hsiao, Yu-Jer, Lai, Wei-Yi, Lai, Yun-Hsien, Yang, Tien-Chun, Chen, Shih-Jen, Huang, Pin-I, Chiou, Shih-Hwa, Mou, Chung-Yuan, Chien, Yueh

“…The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine…”
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Prediction of treatment outcome in neovascular age-related macular degeneration using a novel convolutional neural network by Yeh, Tsai-Chu, Luo, An-Chun, Deng, Yu-Shan, Lee, Yu-Hsien, Chen, Shih-Jen, Chang, Po-Han, Lin, Chun-Ju, Tai, Ming-Chi, Chou, Yu-Bai

“…While prognosis and risk of progression are crucial in developing precise therapeutic strategy in neovascular age-related macular degeneration (nAMD), limited…”
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Brolucizumab in recalcitrant neovascular age-related macular degeneration-real-world data in Chinese population by Weng, Chang-Chi, Chi, Sheng-Chu, Lin, Tai-Chi, Huang, Yi-Ming, Chou, Yu-Bai, Hwang, De-Kuang, Chen, Shih-Jen

“…This retrospective study aimed to determine the short-term efficacy and safety of brolucizumab treatment for recalcitrant neovascular age-related macular…”
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Epidemiology of idiopathic central serous chorioretinopathy in Taiwan, 2001-2006: a population-based study by Tsai, Der-Chong, Chen, Shih-Jen, Huang, Chin-Chou, Chou, Pesus, Chung, Chia-Min, Huang, Po-Hsun, Lin, Shing-Jong, Chen, Jaw-Wen, Chen, Tseng-Ji, Leu, Hsin-Bang, Chan, Wan-Leong

“…The epidemiology of idiopathic central serous chorioretinopathy (CSCR) is not well understood in an Asian population. The present study aimed to investigate…”
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Flow signal change in polyps after anti-vascular endothelial growth factor therapy by Chang, Chia-Jui, Huang, Yi-Ming, Hsieh, Ming-Hung, Li, An-Fei, Chen, Shih-Jen

“…Optical coherence tomography angiography (OCTA) is a novel, non-invasive imaging tool used to detect vascular flow. The absence of a flow signal in OCTA in…”
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Deep learning and ensemble stacking technique for differentiating polypoidal choroidal vasculopathy from neovascular age-related macular degeneration by Chou, Yu-Bai, Hsu, Chung-Hsuan, Chen, Wei-Shiang, Chen, Shih-Jen, Hwang, De-Kuang, Huang, Yi-Ming, Li, An-Fei, Lu, Henry Horng-Shing

“…Polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) share some similarity in clinical imaging manifestations…”
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Nanoparticles-mediated CRISPR-Cas9 gene therapy in inherited retinal diseases: applications, challenges, and emerging opportunities by Chien, Yueh, Hsiao, Yu-Jer, Chou, Shih-Jie, Lin, Ting-Yi, Yarmishyn, Aliaksandr A, Lai, Wei-Yi, Lee, Meng-Shiue, Lin, Yi-Ying, Lin, Tzu-Wei, Hwang, De-Kuang, Lin, Tai-Chi, Chiou, Shih-Hwa, Chen, Shih-Jen, Yang, Yi-Ping

“…Abstract Inherited Retinal Diseases (IRDs) are considered one of the leading causes of blindness worldwide. However, the majority of them still lack a safe and…”
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Pluripotent Stem Cells in Clinical Cell Transplantation: Focusing on Induced Pluripotent Stem Cell-Derived RPE Cell Therapy in Age-Related Macular Degeneration by Yang, Yi-Ping, Hsiao, Yu-Jer, Chang, Kao-Jung, Foustine, Shania, Ko, Yu-Ling, Tsai, Yi-Ching, Tai, Hsiao-Yun, Ko, Yu-Chieh, Chiou, Shih-Hwa, Lin, Tai-Chi, Chen, Shih-Jen, Chien, Yueh, Hwang, De-Kuang

“…Human pluripotent stem cells (PSCs), including both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represent valuable cell sources to…”
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Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis by Huang, Kang-Chieh, Wang, Mong-Lien, Chen, Shih-Jen, Kuo, Jean-Cheng, Wang, Won-Jing, Nhi Nguyen, Phan Nguyen, Wahlin, Karl J., Lu, Jyh-Feng, Tran, Audrey A., Shi, Michael, Chien, Yueh, Yarmishyn, Aliaksandr A., Tsai, Ping-Hsing, Yang, Tien-Chun, Jane, Wann-Neng, Chang, Chia-Ching, Peng, Chi-Hsien, Schlaeger, Thorsten M., Chiou, Shih-Hwa

“…X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated…”
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Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9‐Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X‐Linked Juvenile Retinoschisis by Chou, Shih‐Jie, Yang, Peng, Ban, Qian, Yang, Yi‐Ping, Wang, Mong‐Lien, Chien, Chian‐Shiu, Chen, Shih‐Jen, Sun, Na, Zhu, Yazhen, Liu, Hongtao, Hui, Wenqiao, Lin, Tai‐Chi, Wang, Fang, Zhang, Ryan Yue, Nguyen, Viet Q., Liu, Wenfei, Chen, Mengxiang, Jonas, Steve J., Weiss, Paul S., Tseng, Hsian‐Rong, Chiou, Shih‐Hwa

“…The homology‐independent targeted integration (HITI) strategy enables effective CRISPR/Cas9‐mediated knockin of therapeutic genes in nondividing cells in vivo,…”
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Genetics behind Cerebral Disease with Ocular Comorbidity: Finding Parallels between the Brain and Eye Molecular Pathology by Chang, Kao-Jung, Wu, Hsin-Yu, Yarmishyn, Aliaksandr A, Li, Cheng-Yi, Hsiao, Yu-Jer, Chi, Yi-Chun, Lo, Tzu-Chen, Dai, He-Jhen, Yang, Yi-Chiang, Liu, Ding-Hao, Hwang, De-Kuang, Chen, Shih-Jen, Hsu, Chih-Chien, Kao, Chung-Lan

“…Cerebral visual impairments (CVIs) is an umbrella term that categorizes miscellaneous visual defects with parallel genetic brain disorders. While the…”
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Elongation of Axon Extension for Human iPSC-Derived Retinal Ganglion Cells by a Nano-Imprinted Scaffold by Yang, Tien-Chun, Chuang, Jen-Hua, Buddhakosai, Waradee, Wu, Wen-Ju, Lee, Chen-Ju, Chen, Wun-Syuan, Yang, Yi-Ping, Li, Ming-Chia, Peng, Chi-Hsien, Chen, Shih-Jen

“…Optic neuropathies, such as glaucoma and Leber's hereditary optic neuropathy (LHON) lead to retinal ganglion cell (RGC) loss and therefore motivate the…”
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Inner Nuclear Layer Microcyst Configuration, Distribution, and Visual Prognosis in Patients With Epiretinal Membrane After Vitrectomy and Membrane Peeling by Hsieh, Ming-Hung, Chou, Yu-Bai, Huang, Yi-Ming, Hwang, De-Kuang, Tsai, Fang-Yi, Chen, Shih-Jen

“…Inner nuclear layer(INL) microcysts at central macula are a common finding in patients with epiretinal membrane (ERM) after vitrectomy and membrane peeling…”
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Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation by Kao, Chung-Lan, Chen, Liang-Kung, Chang, Yuh-Lih, Yung, Ming-Chih, Hsu, Chuan-Chih, Chen, Yu-Chih, Lo, Wen-Liang, Chen, Shih-Jen, Ku, Hung-Hai, Hwang, Shin-Jang

“…Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an essential mediator of longevity in normal cells by calorie…”
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Prevalence and associated risk factors of myopic maculopathy in elderly Chinese: the Shihpai eye study by Chen, Shih-Jen, Cheng, Ching-Yu, Li, An-Fei, Peng, Kai-Ling, Chou, Pesus, Chiou, Shih-Hwa, Hsu, Wen-Ming

“…To assess the prevalence and associated risk factors of myopic maculopathy in an elderly Chinese population in Taiwan. Population-based, cross-sectional study…”
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Apoptosis as a primary defense mechanism in response to viral infection in invasive fire ant Solenopsis invicta by Hsu, Hung-Wei, Chiu, Ming-Chung, Shih, Chen-Jen, Matsuura, Kenji, Yang, Chin-Cheng Scotty

“…Apoptosis is considered an innate defense mechanism of insect hosts at the early stage of pathogen infection. The present study attempts to determine whether…”
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Nanomedicine-based Curcumin Approach Improved ROS Damage in Best Dystrophy-specific Induced Pluripotent Stem Cells by Lin, Tai-Chi, Lin, Yi-Ying, Hsu, Chih-Chen, Yang, Yi-Ping, Yang, Chang-Hao, Hwang, De-Kuang, Wang, Chien-Ying, Liu, Yung-Yang, Lo, Wen-Liang, Chiou, Shih-Hwa, Peng, Chi-Hsien, Chen, Shih-Jen, Chang, Yuh-Lih

“…Best dystrophy (BD), also termed best vitelliform macular dystrophy (BVMD), is a juvenile-onset form of macular degeneration and can cause central visual loss…”
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