Search Results - "Chen, Sherry Xi"

An Engineered Kinetic Amplification Mechanism for Single Nucleotide Variant Discrimination by DNA Hybridization Probes by Chen, Sherry Xi, Seelig, Georg

“…Even a single-nucleotide difference between the sequences of two otherwise identical biological nucleic acids can have dramatic functional consequences. Here,…”
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Optimizing the specificity of nucleic acid hybridization by Zhang, David Yu, Chen, Sherry Xi, Yin, Peng

“…The specific hybridization of complementary sequences is an essential property of nucleic acids, enabling diverse biological and biotechnological reactions and…”
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Calibration-free NGS quantitation of mutations below 0.01% VAF by Dai, Peng, Wu, Lucia Ruojia, Chen, Sherry Xi, Wang, Michael Xiangjiang, Cheng, Lauren Yuxuan, Zhang, Jinny Xuemeng, Hao, Pengying, Yao, Weijie, Zarka, Jabra, Issa, Ghayas C., Kwong, Lawrence, Zhang, David Yu

“…Quantitation of rare somatic mutations is essential for basic research and translational clinical applications including minimal residual disease (MRD)…”
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Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling by Wu, Lucia Ruojia, Dai, Peng, Wang, Michael Xiangjiang, Chen, Sherry Xi, Cohen, Evan N., Jayachandran, Gitanjali, Zhang, Jinny Xuemeng, Serrano, Angela V., Xie, Nina Guanyi, Ueno, Naoto T., Reuben, James M., Barcenas, Carlos H., Zhang, David Yu

“…Current gold standard for absolute quantitation of a specific DNA sequence is droplet digital PCR (ddPCR), which has been applied to copy number variation…”
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Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA by Chen, Sherry Xi, Zhang, David Yu, Seelig, Georg

“…Small variations in nucleic acid sequences can have far-reaching phenotypic consequences. Reliably distinguishing closely related sequences is therefore…”
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