Search Results - "Chen, Saijuan"
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Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies
Published in Frontiers of medicine (01-04-2020)“…Since the outbreak of the COVID-19 pandemic in early December 2019, 81 174 confirmed cases and 3242 deaths have been reported in China as of March 19, 2020…”
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Viral and host factors related to the clinical outcome of COVID-19
Published in Nature (London) (16-07-2020)“…In December 2019, coronavirus disease 2019 (COVID-19), which is caused by the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was…”
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Effectiveness of convalescent plasma therapy in severe COVID-19 patients
Published in Proceedings of the National Academy of Sciences - PNAS (28-04-2020)“…Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by…”
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Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions
Published in Frontiers of medicine (01-04-2020)“…The outbreak of a novel coronavirus disease (COVID-19, caused by the 2019-nCoV infection) in December 2019 is one of the most severe public health emergencies…”
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Integrated analysis of gut microbiome and host immune responses in COVID-19
Published in Frontiers of medicine (01-04-2022)“…Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectious diseases. Here, to explore the role of the gut…”
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Back to the spring of 2020 : facts and hope of COVID-19 outbreak
Published in Frontiers of medicine (01-04-2020)Get full text
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Revisiting China’s response to coronavirus disease 2019
Published in Frontiers of medicine (01-12-2023)Get full text
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Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells
Published in Cell cycle (Georgetown, Tex.) (2015)“…Cordycepin, an adenosine analog derived from Cordyceps militaris has been shown to exert anti-tumor activity in many ways. However, the mechanisms by which…”
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PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19
Published in Frontiers of medicine (01-04-2022)“…Pathogenic microbes can induce cellular dysfunction, immune response, and cause infectious disease and other diseases including cancers. However, the cellular…”
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Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia
Published in Leukemia (01-09-2020)Get full text
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Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway
Published in Cell death and differentiation (2021)“…Microglia are the primary immune cells in the central nervous system, which plays a vital role in neuron development and neurodegenerative diseases. Microglial…”
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Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia
Published in Frontiers of medicine (2021)“…B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with high heterogeneity. Precise subtypes with distinct genomic…”
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RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Published in Proceedings of the National Academy of Sciences - PNAS (23-06-2020)“…Retinoic acid-inducible gene I (RIG-I) is up-regulated during granulocytic differentiation of acute promyelocytic leukemia (APL) cells induced by all-trans…”
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Cellular hierarchy insights reveal leukemic stem-like cells and early death risk in acute promyelocytic leukemia
Published in Nature communications (16-02-2024)“…Acute promyelocytic leukemia (APL) represents a paradigm for targeted differentiation therapy, with a minority of patients experiencing treatment failure and…”
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Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects
Published in Cell research (01-11-2021)“…Increasing numbers of SARS-CoV-2-positive (SARS-CoV-2 pos ) subjects are detected at silent SARS-CoV-2 infection stage (SSIS). Yet, SSIS represents a poorly…”
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Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia
Published in Frontiers of medicine (01-08-2021)“…t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy with a high relapse rate in China. Two leukemic myeloblast…”
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Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
Published in Frontiers of medicine (01-12-2020)“…The ongoing pandemic of coronavirus disease 19 (COVID-19) is caused by a newly discovered β coronavirus named severe acute respiratory syndrome coronavirus 2…”
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Pangenomic analysis of Chinese gastric cancer
Published in Nature communications (15-09-2022)“…Pangenomic study might improve the completeness of human reference genome (GRCh38) and promote precision medicine. Here, we use an automated pipeline of human…”
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CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis
Published in Nature communications (21-08-2023)“…Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show…”
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Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland
Published in Frontiers of medicine (01-08-2023)“…With the recent ongoing autumn/winter 2022 COVID-19 wave and the adjustment of public health control measures, there have been widespread SARS-CoV-2 infections…”
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