Search Results - "Chen, R. S"

Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance by Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, Saliba, Paul, Sguazzin, Matthew, MacDonald, Melissa E., Paré, Guillaume, Steinberg, Gregory R., Janssen, Luke J., Igdoura, Suleiman A., Tarnopolsky, Mark A., Wayne Chen, S. R., Seidah, Nabil G., Magolan, Jakob, Austin, Richard C.

“…Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered. Here,…”
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Two-dimensional electronic transport and surface electron accumulation in MoS2 by Siao, M. D., Shen, W. C., Chen, R. S., Chang, Z. W., Shih, M. C., Chiu, Y. P., Cheng, C.-M.

“…Because the surface-to-volume ratio of quasi-two-dimensional materials is extremely high, understanding their surface characteristics is crucial for…”
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Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis by Priori, Silvia G, Chen, S.R Wayne

“…Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease occurring in patients with a structurally normal heartthe…”
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Excellent room-temperature ductility and formability of rolled Mg–Gd–Zn alloy sheets by Wu, D., Chen, R.S., Han, E.H.

“…▶ The Mg–Gd–Zn sheets have an oval-shaped distribution of basal poles by the addition of Gd. ▶ The basal texture intensity of the sheets is effectively…”
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Effects of rare-earth elements Gd and Y on the solid solution strengthening of Mg alloys by Gao, L., Chen, R.S., Han, E.H.

“…A number of Mg–Gd, Mg–Y binary and Mg–Gd–Y ternary alloys are investigated in terms of solid solution strengthening efficiency in this work. It is found that…”
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Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity by Eisner, Verónica, Cupo, Ryan R., Gao, Erhe, Csordás, György, Slovinsky, William S., Paillard, Melanie, Cheng, Lan, Ibetti, Jessica, Chen, S. R. Wayne, Chuprun, J. Kurt, Hoek, Jan B., Koch, Walter J., Hajnóczky, György

“…Mitochondrial fusion is thought to be important for supporting cardiac contractility, but is hardly detectable in cultured cardiomyocytes and is difficult to…”
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RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation by Guo, Wenting, Wei, Jinhong, Estillore, John Paul, Zhang, Lin, Wang, Ruiwu, Sun, Bo, Chen, S. R. Wayne

“…Ryanodine receptors (RyRs) are ion channels that mediate the release of Ca2+ from the sarcoplasmic reticulum/endoplasmic reticulum, mutations of which are…”
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First Report of Leaf Spot Disease of Pineapple Caused by Penicillium oxalicum by Wu, J-B, He, Y-B, Chen, R-S

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The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability by Guo, Wenting, Sun, Bo, Estillore, John Paul, Wang, Ruiwu, Chen, S. R.Wayne

“…Structural analyses identified the central domain of ryanodine receptor (RyR) as a transducer converting conformational changes in the cytoplasmic platform to…”
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Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation by Tambeaux, Allison, Aguilar-Sánchez, Yuriana, Santiago, Demetrio J., Mascitti, Madeleine, DiNovo, Karyn M., Mejía-Alvarez, Rafael, Fill, Michael, Wayne Chen, S. R., Ramos-Franco, Josefina

“…Inositol 1,4,5-trisphosphate receptor (IP 3 R) and ryanodine receptor (RyR) are homologous cation channels that mediate release of Ca 2+ from the…”
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The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias by Chen, Wenqian, Wang, Ruiwu, Chen, Biyi, Zhong, Xiaowei, Kong, Huihui, Bai, Yunlong, Zhou, Qiang, Xie, Cuihong, Zhang, Jingqun, Guo, Ang, Tian, Xixi, Jones, Peter P, O'Mara, Megan L, Liu, Yingjie, Mi, Tao, Zhang, Lin, Bolstad, Jeff, Semeniuk, Lisa, Cheng, Hongqiang, Zhang, Jianlin, Chen, Ju, Tieleman, D Peter, Gillis, Anne M, Duff, Henry J, Fill, Michael, Song, Long-Sheng, Chen, S R Wayne

“…In heart muscle cells, sarcoplasmic reticulum calcium overload leads to spontaneous calcium waves that can cause arrhythmias and sudden cardiac death. S.R…”
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Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2 by Peng, Wei, Shen, Huaizong, Wu, Jianping, Guo, Wenting, Pan, Xiaojing, Wang, Ruiwu, Chen, S. R. Wayne, Yan, Nieng

“…RyR2 is a high-conductance intracellular calcium (Ca ) channel that controls the release of Ca from the sarco(endo)plasmic reticulum of a variety of cells…”
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Solid solution strengthening behaviors in binary Mg–Y single phase alloys by Gao, L., Chen, R.S., Han, E.H.

“…Solid solution effects on the mechanical behavior of binary Mg–Y single phase alloys have been investigated in a temperature range from ambient to 350 °C with…”
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Axoplasmic reticulum Ca2+ release causes secondary degeneration of spinal axons by Stirling, David P., Cummins, Karen, Wayne Chen, S. R., Stys, Peter

“…Objective Transected axons of the central nervous system fail to regenerate and instead die back away from the lesion site, resulting in permanent disability…”
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Modulation of cardiac ryanodine receptor 2 by calmodulin by Gong, Deshun, Chi, Ximin, Wei, Jinhong, Zhou, Gewei, Huang, Gaoxingyu, Zhang, Lin, Wang, Ruiwu, Lei, Jianlin, Chen, S. R. Wayne, Yan, Nieng

“…The high-conductance intracellular calcium (Ca 2+ ) channel RyR2 is essential for the coupling of excitation and contraction in cardiac muscle. Among various…”
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Correlation between dynamic recrystallization and formation of rare earth texture in a Mg-Zn-Gd magnesium alloy during extrusion by Jiang, M. G., Xu, C., Yan, H., Lu, S. H., Nakata, T., Lao, C. S., Chen, R. S., Kamado, S., Han, E. H.

“…The trace addition of rare earth (RE) elements in Mg alloys can modify the extrusion texture, leading to the formation of RE texture and thus improved…”
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Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor by Kong, Huihui, Jones, Peter P, Koop, Andrea, Zhang, Lin, Duff, Henry J, Chen, S R Wayne

“…Caffeine has long been used as a pharmacological probe for studying RyR (ryanodine receptor)-mediated Ca(2+) release and cardiac arrhythmias. However, the…”
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Enhanced Store Overload–Induced Ca2+ Release and Channel Sensitivity to Luminal Ca2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death by Jiang, Dawei, Wang, Ruiwu, Xiao, Bailong, Kong, Huihui, Hunt, Donald J, Choi, Philip, Zhang, Lin, Chen, S R. Wayne

“…Ventricular tachycardia (VT) is the leading cause of sudden death, and the cardiac ryanodine receptor (RyR2) is emerging as an important focus in its…”
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Precise prediction of phase-separation key residues by machine learning by Sun, Jun, Qu, Jiale, Zhao, Cai, Zhang, Xinyao, Liu, Xinyu, Wang, Jia, Wei, Chao, Liu, Xinyi, Wang, Mulan, Zeng, Pengguihang, Tang, Xiuxiao, Ling, Xiaoru, Qing, Li, Jiang, Shaoshuai, Chen, Jiahao, Chen, Tara S. R., Kuang, Yalan, Gao, Jinhang, Zeng, Xiaoxi, Huang, Dongfeng, Yuan, Yong, Fan, Lili, Yu, Haopeng, Ding, Junjun

“…Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the…”
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Effects of ageing treatment on microstructures and properties of Mg–Gd–Y–Zr alloys with and without Zn additions by Liu, X.B., Chen, R.S., Han, E.H.

“…Mg–10Gd–3Y–0.5Zr alloys with and without 1% Zn additions have been investigated using optical microscopy, scanning electron microscope and X-ray diffraction…”
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