Search Results - "Chen, Owen J"

The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses by Ladak, Reese Jalal, Choi, Jung-Hyun, Luo, Jun, Chen, Owen J., Mahmood, Niaz, He, Alexander J., Naeli, Parisa, Snell, Patric Harris, Bayani, Esha, Hoang, Huy-Dung, Alain, Tommy, Teodoro, Jose G., Wang, Jianwei, Zhang, Xu, Jafarnejad, Seyed Mehdi, Sonenberg, Nahum

“…A critical host response against viral infections entails the activation of innate immune signaling that culminates in the production of antiviral proteins…”
Get full text

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer by Chen, Owen J, Castellsagué, Ester, Moustafa-Kamal, Mohamed, Nadaf, Javad, Rivera, Barbara, Fahiminiya, Somayyeh, Wang, Yilin, Gamache, Isabelle, Pacifico, Caterina, Jiang, Lai, Carrot-Zhang, Jian, Witkowski, Leora, Berghuis, Albert M, Schönberger, Stefan, Schneider, Dominik, Hillmer, Morten, Bens, Susanne, Siebert, Reiner, Stewart, Colin J R, Zhang, Ziguo, Chao, William C H, Greenwood, Celia M T, Barford, David, Tischkowitz, Marc, Majewski, Jacek, Foulkes, William D, Teodoro, Jose G

“…CDC20 is a coactivator of the anaphase promoting complex/cyclosome (APC/C) and is essential for mitotic progression. APC/CCDC20 is inhibited by the spindle…”
Get full text

Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer by Mohammad, Amro H, Kim, Sung-Hoon, Bertos, Nicholas, El-Assaad, Wissal, Nandi, Ipshita, Smith, Harvey, Yang, Jieyi, Chen, Owen J, Gamache, Isabelle, Rao, Trisha, Gagnon, Bruno, Gruosso, Tina, Tremblay, Michel L, Sonenberg, Nahum, Guiot, Marie-Christine, Muller, William, Park, Morag, Teodoro, Jose G

“…PTEN loss-of-function contributes to hyperactivation of the PI3K pathway and to drug resistance in breast cancer. Unchecked PI3K pathway signaling increases…”
Get full text

Cancer patient perspectives during the COVID-19 pandemic: A thematic analysis of cancer blog posts by Hintermayer, Matthew A, Sorin, Mark, Romero, Joan M, Maritan, Sarah M, Chen, Owen J, Rawal, Surabhi

“…The content of online cancer patient blogs has previously been analyzed to inform physicians about the cancer experience and patient concerns. The coronavirus…”
Get full text

Genetic Modifications in Cdc20 in Mice: An Approach to Generate Mouse Models with Precise Edits in Essential Genes Using CRISPR-Cas9 by Chen, Owen J

“…Gene editing has been a long-time tool for phenotypic studies in mice. The laboratory mouse (Mus musculus) provides a biologically relevant physiological…”
Get full text