Search Results - "Chen, Muwan"

Protocol for generating reproducible miniaturized controlled midbrain organoids by Chen, Muwan, Niclis, Jonathan Christos, Denham, Mark

“…Here, we present a protocol for generating miniaturized controlled midbrain organoids (MiCOs) of reproducible size and cellular composition, without a necrotic…”
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Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells by Maimaitili, Muyesier, Chen, Muwan, Febbraro, Fabia, Ucuncu, Ekin, Kelly, Rachel, Niclis, Jonathan Christos, Christiansen, Josefine Rågård, Mermet-Joret, Noëmie, Niculescu, Dragos, Lauritsen, Johanne, Iannielli, Angelo, Klæstrup, Ida H., Jensen, Uffe Birk, Qvist, Per, Nabavi, Sadegh, Broccoli, Vania, Nykjær, Anders, Romero-Ramos, Marina, Denham, Mark

“…Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in grafts containing only…”
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Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense by Sun, Ming, Yang, Chuanxu, Zheng, Jin, Wang, Miao, Chen, Muwan, Le, Dang Quang Svend, Kjems, Jørgen, Bünger, Cody Eric

“…[Display omitted] While chemotherapy is universally recognized as a frontline treatment strategy for breast cancer, it is not always successful; among the…”
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A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds by Zou, Lijin, Luo, Yonglun, Chen, Muwan, Wang, Gang, Ding, Ming, Petersen, Charlotte Christie, Kang, Ran, Dagnaes-Hansen, Frederik, Zeng, Yuanlin, Lv, Nonghua, Ma, Qing, Le, Dang Q. S., Besenbacher, Flemming, Bolund, Lars, Jensen, Thomas G., Kjems, Jørgen, Pu, William T., Bünger, Cody

“…We describe a simple method for bone engineering using biodegradable scaffolds with mesenchymal stem cells derived from human induced-pluripotent stem cells…”
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Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering by Chen, Muwan, Le, Dang Q.S., Baatrup, Anette, Nygaard, Jens V., Hein, San, Bjerre, Lea, Kassem, Moustapha, Zou, Xuenong, Bünger, Cody

“…It is of high clinical relevance in bone tissue engineering that scaffolds promote a high seeding efficiency of cells capable of osteogenic differentiation,…”
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Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells by Chen, Muwan, Maimaitili, Muyesier, Habekost, Mette, Gill, Katherine P., Mermet-Joret, Noëmie, Nabavi, Sadegh, Febbraro, Fabia, Denham, Mark

“…Direct neuronal conversion of pluripotent stem cells with a single factor NGN2 yielded a mixed neuronal culture containing peripheral and CNS neurons. By…”
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Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations by Chen, Muwan, Maimaitili, Muyesier, Buchholdt, Susanne Hvolbøl, Jensen, Uffe Birk, Febbraro, Fabia, Denham, Mark

“…We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating…”
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Generation of an induced pluripotent stem cell line (DANi-011A) from a Parkinson's disease patient with a LRRK2 p.G2019S mutation by Chen, Muwan, Maimaitili, Muyesier, Buchholdt, Susanne Hvolbøl, Jensen, Uffe Birk, Febbraro, Fabia, Denham, Mark

“…We generated an induced pluripotent stem cell (iPSC) line from fibroblasts of a clinically diagnosed 70 year old female Parkinson's disease (PD) patient…”
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Dental pulp-derived stromal cells exhibit a higher osteogenic potency than bone marrow-derived stromal cells in vitro and in a porcine critical-size bone defect model by Jensen, Jonas, Tvedesøe, Claus, Rölfing, Jan Hendrik Duedal, Foldager, Casper Bindzus, Lysdahl, Helle, Kraft, David Christian Evar, Chen, Muwan, Baas, Jorgen, Le, Dang Quang Svend, Bünger, Cody Eric

“…The osteogenic differentiation of bone marrow-derived mesenchymal stromal cells (BMSCs) was compared with that of dental pulp-derived stromal cells (DPSCs) in…”
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A Modified Monomeric Red Fluorescent Protein Reporter for Assessing CRISPR Activity by Højland Knudsen, Camilla, Ásgrímsdóttir, Emilía S, Rahimi, Karim, Gill, Katherine P, Frandsen, Søs, Hvolbøl Buchholdt, Susanne, Chen, Muwan, Kjems, Jørgen, Febbraro, Fabia, Denham, Mark

“…Gene editing in human embryonic stem cells (hESCs) has been significantly enhanced by the discovery and development of CRISPR Cas9, a programmable nuclease…”
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Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs by Chen, Muwan, Laursen, Sofie H, Habekost, Mette, Knudsen, Camilla H, Buchholdt, Susanne H, Huang, Jinrong, Xu, Fengping, Liu, Xin, Bolund, Lars, Luo, Yonglun, Nissen, Poul, Febbraro, Fabia, Denham, Mark

“…The P-type ATPases family consists of ion and lipid transporters. Their unique diversity in function and expression is critical for normal development. In this…”
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A traditional Chinese medicine formula extracts stimulate proliferation and inhibit mineralization of human mesenchymal stem cells in vitro by Chen, Muwan, Feng, Wenzhou, Cao, Hui, Zou, Lijin, Chen, Chungui, Baatrup, Anette, Nielsen, Anne Bay, Li, Haisheng, Kassem, Moustapha, Zou, Xuenong, Bünger, Cody

“…To investigate the effects of a traditional Chinese medicine (TCM) formula extract, named as ZD-I, on the proliferation and osteogenic differentiation of human…”
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Generation of Human iPSCs by Episomal Reprogramming of Skin Fibroblasts and Peripheral Blood Mononuclear Cells by Febbraro, Fabia, Chen, Muwan, Denham, Mark

“…Human-induced pluripotent stem cells (iPSCs) can be generated from patient-specific somatic cells by forced expression of the transcription factors OCT4, SOX2,…”
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TMEFF1 is a neuron-specific restriction factor for herpes simplex virus by Dai, Yao, Idorn, Manja, Serrero, Manutea C., Pan, Xiaoyong, Thomsen, Emil A., Narita, Ryo, Maimaitili, Muyesier, Qian, Xiaoqing, Iversen, Marie B., Reinert, Line S., Flygaard, Rasmus K., Chen, Muwan, Ding, Xiangning, Zhang, Bao-cun, Carter-Timofte, Madalina E., Lu, Qing, Jiang, Zhuofan, Zhong, Yiye, Zhang, Shuhui, Da, Lintai, Zhu, Jinwei, Denham, Mark, Nissen, Poul, Mogensen, Trine H., Mikkelsen, Jacob Giehm, Zhang, Shen-Ying, Casanova, Jean-Laurent, Cai, Yujia, Paludan, Søren R.

“…The brain is highly sensitive to damage caused by infection and inflammation 1 , 2 . Herpes simplex virus 1 (HSV-1) is a neurotropic virus and the cause of…”
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Interference in the endplate nutritional pathway causes intervertebral disc degeneration in an immature porcine model by Kang, Ran, Li, Haisheng, Ringgaard, Steffen, Rickers, Kresten, Sun, Haolin, Chen, Muwan, Xie, Lin, Bünger, Cody

“…Purpose Previous studies have shown that blocking the endplate nutritional pathway with bone cement did not result in obvious intervertebral disc degeneration…”
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Functionalization of polycaprolactone scaffolds with hyaluronic acid and β-TCP facilitates migration and osteogenic differentiation of human dental pulp stem cells in vitro by Jensen, Jonas, Kraft, David Christian Evar, Lysdahl, Helle, Foldager, Casper Bindzus, Chen, Muwan, Kristiansen, Asger Albæk, Rölfing, Jan Hendrik Duedal, Bünger, Cody Eric

“…In this study, we sought to assess the osteogenic potential of human dental pulp stem cells (DPSCs) on three different polycaprolactone (PCL) scaffolds. The…”
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A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo by Sun, Ming, Wang, Miao, Chen, Muwan, Dagnaes-Hansen, Frederik, Le, Dang Quang Svend, Baatrup, Anette, Horsman, Michael R., Kjems, Jørgen, Bünger, Cody Eric

“…[Display omitted] Bone metastasis is one of the leading causes of death in breast cancer patients. The current treatment is performed as a palliative therapy…”
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A single topical dose of erythropoietin applied on a collagen carrier enhances calvarial bone healing in pigs by Rölfing, Jan Hendrik Duedal, Jensen, Jonas, Jensen, Julie Neerup, Greve, Anne-Sofie, Lysdahl, Helle, Chen, Muwan, Rejnmark, Lars, Bünger, Cody

“…Background and purpose - The osteogenic potency of erythropoietin (EPO) has been documented. However, its efficacy in a large-animal model has not yet been…”
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Spatially Controlled Delivery of siRNAs to Stem Cells in Implants Generated by Multi-Component Additive Manufacturing by Andersen, Morten Østergaard, Le, Dang Quang Svend, Chen, Muwan, Nygaard, Jens Vinge, Kassem, Moustapha, Bünger, Cody, Kjems, Jørgen

“…Additive manufacturing is a promising technique in tissue engineering, as it enables truly individualized implants to be made to fit a particular defect. As…”
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Fabrication and characterization of a rapid prototyped tissue engineering scaffold with embedded multicomponent matrix for controlled drug release by Chen, Muwan, Le, Dang Q S, Hein, San, Li, Pengcheng, Nygaard, Jens V, Kassem, Moustapha, Kjems, Jørgen, Besenbacher, Flemming, Bünger, Cody

“…Bone tissue engineering implants with sustained local drug delivery provide an opportunity for better postoperative care for bone tumor patients because these…”
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