Search Results - "Chen, Kuey C."
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Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment
Published in The Journal of neuroscience (11-02-2009)“…Multiple hippocampal processes and cognitive functions change with aging or Alzheimer's disease, but the potential triggers of these aging cascades are not…”
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Distinct Effects of Mitochondrial Na+/Ca2+ Exchanger Inhibition and Ca2+ Uniporter Activation on Ca2+ Sparks and Arrhythmogenesis in Diabetic Rats
Published in Journal of the American Heart Association (18-07-2023)“…Background Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca2+ concentration ([Ca2+]m)…”
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Intrarenal Renin Angiotensin System Imbalance During Postnatal Life Is Associated With Increased Microvascular Density in the Mature Kidney
Published in Frontiers in physiology (01-09-2020)“…Environmental stress during early life is an important factor that affects the postnatal renal development. We have previously shown that male rats exposed to…”
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Corrigendum: Intrarenal Renin Angiotensin System Imbalance During Postnatal Life Is Associated With Increased Microvascular Density in the Mature Kidney
Published in Frontiers in physiology (16-11-2020)“…[This corrects the article DOI: 10.3389/fphys.2020.01046.]…”
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Distinct Effects of Mitochondrial Na + /Ca 2+ Exchanger Inhibition and Ca 2+ Uniporter Activation on Ca 2+ Sparks and Arrhythmogenesis in Diabetic Rats
Published in Journal of the American Heart Association (18-07-2023)“…Background Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca concentration ([Ca ] )…”
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Hypoxia‐inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues
Published in Immunology (01-07-2018)“…Summary Hypoxia (i.e. oxygen deprivation) activates the hypoxia‐signalling pathway, primarily via hypoxia‐inducible transcription factors (HIF) for numerous…”
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1306-P: In Vivo Downregulation of Pancreatic Amylin in Diabetic Mice Improves Recognition Memory
Published in Diabetes (New York, N.Y.) (01-06-2022)“…Hypersecretion of amylin, a β-cell hormone that regulates satiation, is common in individuals with prediabetes and is associated with pancreatic amyloid…”
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Pituitary and liver selenoprotein transcriptome profiles of grazing steers and their sensitivity to the form of selenium in vitamin-mineral mixes
Published in Frontiers in animal science (04-08-2022)“…Many supplemental Se-dependent metabolic effects are mediated through the function of selenoproteins. The full complement and relative abundance of…”
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Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: Protection by diosgenin and l-deprenyl
Published in Neurobiology of disease (01-07-2006)“…Human immunodeficiency virus (HIV) infection continues to rise in drug-abusing populations and causes a dementing illness in a subset of individuals. Factors…”
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Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
Published in Communications biology (03-01-2023)“…Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated with…”
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Abstract 128: In Vivo Downregulation Of Pancreatic Amylin In Diabetic Mice Improves Recognition Memory
Published in Stroke (1970) (01-02-2023)“…Hypersecretion of amylin, a β-cell hormone that regulates satiation, is common in individuals with prediabetes and is associated with pancreatic amyloid…”
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The evolutionary history of the first three enzymes in pyrimidine biosynthesis
Published in BioEssays (01-03-1993)“…Some metabolic pathways are nearly ubiquitous among organisms: the genes encoding the enzymes for such pathways must therefore be ancient and essential. De…”
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