Search Results - "Chen, Kuangyang"
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MAFLD in Patients with Cushing’s Disease Is Negatively Associated with Low Free Thyroxine Levels Rather than with Cortisol or TSH Levels
Published in International journal of endocrinology (12-04-2023)“…Purpose. This study aims to analyze the clinical characteristic of metabolic associated fatty liver disease (MAFLD) in patients with active Cushing’s disease…”
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Associations between cardiometabolic indices and the risk of diabetic kidney disease in patients with type 2 diabetes
Published in Cardiovascular diabetology (25-04-2024)“…This study was designed to assess the associations between emerging cardiometabolic indices-the atherogenic index of plasma (AIP), the stress hyperglycemia…”
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Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice
Published in Nature communications (28-11-2022)“…Secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is a poorly characterized secreted protein of largely unknown physiological…”
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Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm
Published in International journal of molecular sciences (01-09-2022)“…Endoplasmic reticulum membrane protein complex subunit 10 (EMC10) is an evolutionarily conserved and multifunctional factor across species. We previously…”
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1631-P: scEMC10 Suppresses Glucose Uptake in Skeletal Muscle via the Inhibition of AMPK Signaling
Published in Diabetes (New York, N.Y.) (20-06-2023)“…Skeletal muscle is one of the most important organs involved in the glucose metabolism, and is mainly responsible for postprandial glucose uptake. We have…”
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1549-P: scEMC10 Promotes Glucose Intolerance via the Inhibition of PKA-Mediated Insulin Secretion
Published in Diabetes (New York, N.Y.) (20-06-2023)“…It has been shown recently that overexpression of the secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) impairs, whereas Emc10…”
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300-OR: The Transcriptional Coregulator CITED2 Suppresses Expression of IRS-2 in Endothelial Cells and Impairs Vascular Insulin Signaling In Vivo
Published in Diabetes (New York, N.Y.) (01-06-2020)“…Endothelial insulin signaling regulates perfusion, leukocyte adhesion, and angiogenesis, and its impairment may contribute to the development of vascular…”
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EMC10 modulates hepatic ER stress and steatosis in an isoform-specific manner
Published in Journal of hepatology (01-09-2024)“…Endoplasmic reticulum (ER) membrane protein complex subunit 10 (EMC10) has been implicated in obesity. Here we investigated the roles of the two isoforms of…”
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Serum scEMC10 Levels are Negatively Associated With Resting Metabolic Rate and age in Humans
Published in The journal of clinical endocrinology and metabolism (18-09-2023)“…Abstract Context We have recently shown that the secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is upregulated in human…”
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Identification of hub genes and infiltrating immune cells in skeletal muscle in obesity
Published in Annals of translational medicine (01-10-2022)“…BackgroundMetabolic syndrome (MetS) refers to a cluster of metabolic disorders that are mainly caused by obesity. Skeletal muscle is a central component of…”
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92-OR: EMC10, a Novel Serum Predictor for Coronary Artery Disease, Exerts an Impact on the Development of Atherosclerosis via Negatively Modulating Endothelial Insulin Signaling
Published in Diabetes (New York, N.Y.) (01-06-2020)“…Cardiovascular disease is the leading cause of global mortality, accounting for about one third of deaths worldwide. Secreted proteins from metabolically…”
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Endoplasmic Reticulum Membrane Protein Complex 10 (EMC10), a Novel Circulating Factor for Systemic Energy and Metabolic Homeostasis
Published in Diabetes (New York, N.Y.) (01-07-2018)“…Proteins secreted from metabolic organs play critical roles in fine-tuning and maintenance of systemic metabolic and energy homeostasis. In this study, we…”
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