Search Results - "Chen, Ke‐Ming"
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Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling
Published in Journal of cellular physiology (01-03-2013)“…Increasingly natural products particularly flavonoids are being explored for their therapeutic potentials in reducing bone loss and maintaining bone health…”
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Vasculogenic mimicry formation in EBV-associated epithelial malignancies
Published in Nature communications (27-11-2018)“…Epstein-Barr virus (EBV)-associated epithelial cancers, including nasopharyngeal carcinoma (NPC) and approximately 10% of gastric cancers, termed EBVaGC,…”
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Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b/β‐Catenin in Primary Cilia of Osteoblasts
Published in Journal of bone and mineral research (01-07-2019)“…ABSTRACT Extremely low‐frequency electromagnetic fields have been considered a potential candidate for the prevention and treatment of osteoporosis; however,…”
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Neurotrophin‐3 Induces BMP‐2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats
Published in Journal of bone and mineral research (01-06-2016)“…ABSTRACT Injured growth plate is often repaired by bony tissue causing bone growth defects, for which the mechanisms remain unclear. Because neurotrophins have…”
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Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro
Published in Journal of cellular biochemistry (01-03-2011)“…There has been a strong interest in searching for natural therapies for osteoporosis. Genistein, an isoflavone abundant in soy, and icariin, a prenylated…”
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Simulated microgravity-induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia
Published in Journal of cellular physiology (01-11-2023)“…Oxidative stress has been considered to be closely related to spaceflight-induced bone loss; however, mechanism is elusive and there are no effective…”
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A case report of hepatic and pancreatic spontaneous hemorrhage in a patient with systemic lupus erythematous
Published in Therapeutic apheresis and dialysis (01-04-2023)Get full text
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Pulsed electromagnetic fields promote bone formation by activating the sAC–cAMP–PKA–CREB signaling pathway
Published in Journal of cellular physiology (01-03-2019)“…The application of pulsed electromagnetic fields (PEMFs) in the prevention and treatment of osteoporosis has long been an area of interest. However, the…”
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Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity
Published in Journal of cellular and molecular medicine (01-01-2023)“…The molecular mechanism for the microgravity‐induced decrease in bone formation remains unclear and there is a lack of effective specific preventative…”
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Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium
Published in Bone (New York, N.Y.) (01-12-2016)“…Abstract Pulsed electromagnetic fields (PEMFs) have been considered as a potential candidate for the prevention and treatment of osteoporosis, however, the…”
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Icariin attenuates methotrexate chemotherapy‐induced bone marrow microvascular damage and bone loss in rats
Published in Journal of cellular physiology (01-09-2019)“…Methotrexate (MTX), a widely used antimetabolite in paediatric cancer to treatment, has been widely reported to cause bone loss and bone marrow (BM)…”
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Inflammatory anemia may be an indicator for predicting disease activity and structural damage in Chinese patients with rheumatoid arthritis
Published in Clinical rheumatology (01-06-2020)“…Objectives This study aimed to investigate the relationship of serum hemoglobin (HB) level with disease activity and structural damage in Chinese patients with…”
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Childhood cancer chemotherapy–induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals
Published in Annals of the New York Academy of Sciences (01-09-2017)“…Intensive cancer chemotherapy causes significant bone loss, for which the mechanisms remain unclear and effective treatments are lacking. This is a significant…”
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The interdependent relationship between the nitric oxide signaling pathway and primary cilia in pulse electromagnetic field‐stimulated osteoblastic differentiation
Published in The FASEB journal (01-06-2022)“…Pulsed electromagnetic fields (PEMFs) have long been recognized being safe and effective in treating bone fracture nonunion and osteoporosis. However, the…”
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Presence of subclinical inflammation in axial spondyloarthritis patients with NSAID/anti-TNF-α drug-induced clinical remission
Published in Clinical rheumatology (01-05-2022)“…Objective To investigate the rate of subclinical inflammation in patients with axial spondyloarthritis (axSpA) with nonsteroidal anti-inflammatory drug…”
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Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats
Published in Journal of cellular physiology (01-07-2019)“…Cancer chemotherapy can cause significant damage to the bone marrow (BM) microvascular (sinusoidal) system. Investigations must now address whether and how BM…”
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Synergistic effect of sarcopenia and poor balance on osteoporotic vertebral fracture in Chinese patients with rheumatoid arthritis
Published in Clinical rheumatology (01-09-2021)“…Objectives This study aimed to investigate the synergistic effect of sarcopenia and poor balance on osteoporotic vertebral fracture (VOPF) in Chinese patients…”
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The Prenyl Group Contributes to Activities of Phytoestrogen 8-Prenynaringenin in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro
Published in Endocrinology (Philadelphia) (01-03-2013)“…Previous studies have found that 8-prenylflavonoids have a higher osteogenic activity than do flavonoids, which suggested that the 8-prenyl group may play an…”
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Pulsed electromagnetic fields prevented the decrease of bone formation in hindlimb‐suspended rats by activating sAC/cAMP/PKA/CREB signaling pathway
Published in Bioelectromagnetics (01-12-2018)“…Microgravity is one of the main threats to the health of astronauts. Pulsed electromagnetic fields (PEMFs) have been considered as one of the potential…”
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