Search Results - "Chen, John Xi"

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell by Gan, Xueqi, Huang, Shengbin, Wu, Long, Wang, Yongfu, Hu, Gang, Li, Guangyue, Zhang, Hongju, Yu, Haiyang, Swerdlow, Russell Howard, Chen, John Xi, Yan, Shirley ShiDu

“…Mitochondrial dysfunction is an early pathological feature of Alzheimer’s disease (AD). The underlying mechanisms and strategies to repair it remain unclear…”
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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease by Fang, Fang, Zhang, Hong, Yan, Shi Du, Arancio, Ottavio, Chen, Doris, Yan, Yilin, Gunn-Moore, Frank J, Molkentin, Jeffery D, Guo, Lan, Vonsattel, Jean Paul, Wang, Chunyu, M McKhann, Guy, Chen, John Xi, Du, Heng, A Sosunov, Alexander

“…Mitochondrial dysfunction has been described in Alzheimer's disease, but how it is induced has remained unclear. Shi Du Yan and her colleagues find that a…”
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Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction by Gan, Xueqi, Wu, Long, Huang, Shengbin, Zhong, Changjia, Shi, Honglian, Li, Guangyue, Yu, Haiyang, Howard Swerdlow, Russell, Xi Chen, John, Yan, Shirley ShiDu

“…Mild cognitive impairment (MCI) occurs during the predementia stage of Alzheimer disease (AD) and is characterized by a decline in cognitive abilities that…”
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Inhibition of Amyloid-β (Aβ) Peptide-Binding Alcohol Dehydrogenase-Aβ Interaction Reduces Aβ Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease by Yao, Jun, Du, Heng, Yan, Shiqiang, Fang, Fang, Wang, Chaodong, Lue, Lih-Fen, Guo, Lan, Chen, Doris, Stern, David M., Gunn Moore, Frank J., Xi Chen, John, Arancio, Ottavio, Yan, Shirley ShiDu

“…Amyloid-β (Aβ) peptide-binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, exacerbates Aβ-induced cell stress. The interaction of…”
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Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons by Guo, Lan, Du, Heng, Yan, Shiqiang, Wu, Xiaoping, McKhann, Guy M, Chen, John Xi, Yan, Shirley ShiDu

“…Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial…”
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Endophilin I Expression Is Increased in the Brains of Alzheimer Disease Patients by Ren, Yimin, Xu, Hong Wei, Davey, Fleur, Taylor, Margaret, Aiton, Jim, Coote, Peter, Fang, Fang, Yao, Jun, Chen, Doris, Chen, John Xi, Yan, Shi Du, Gunn-Moore, Frank J.

“…Alzheimer patients have increased levels of both the 42 amyloid-β-peptide (Aβ) and the amyloid binding alcohol dehydrogenase (ABAD), which is an intracellular…”
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Role of mitochondrial amyloid-beta in Alzheimer's disease by Chen, John Xi, Yan, Shirley Shidu

“…Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Abnormalities in mitochondrial properties include impaired energy metabolism,…”
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Antioxidants Rescue Mitochondrial Transport in Differentiated Alzheimer's Disease Trans-Mitochondrial Cybrid Cells by Yu, Qing, Fang, Du, Swerdlow, Russell Howard, Yu, Haiyang, Chen, John Xi, Yan, Shirley ShiDu

“…Mitochondrial dysfunction and axonal degeneration are early pathological features of Alzheimer's disease (AD)-affected brains. The underlying mechanisms and…”
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Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration by Du, Heng, Guo, Lan, Wu, Xiaoping, Sosunov, Alexander A., McKhann, Guy M., Chen, John Xi, Yan, Shirley ShiDu

“…The coexistence of neuronal mitochondrial pathology and synaptic dysfunction is an early pathological feature of Alzheimer's disease (AD). Cyclophilin D…”
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Synergistic exacerbation of mitochondrial and synaptic dysfunction and resultant learning and memory deficit in a mouse model of diabetic Alzheimer's disease by Wang, Yongfu, Wu, Long, Li, Jianping, Fang, Du, Zhong, Changjia, Chen, John Xi, Yan, Shirley ShiDu

“…Diabetes is considered to be a risk factor in Alzheimer's disease (AD) pathogenesis. Although recent evidence indicates that diabetes exaggerates pathologic…”
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Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria by Alikhani, Nyosha, Guo, Lan, Yan, Shiqiang, Du, Heng, Pinho, Catarina Moreira, Chen, John Xi, Glaser, Elzbieta, Yan, Shirley ShiDu

“…Accumulation of amyloid-β peptide (Aβ), the neurotoxic peptide implicated in the pathogenesis of Alzheimer's disease (AD), has been shown in brain mitochondria…”
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Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model by Fang, Du, Wang, Yongfu, Zhang, Zhihua, Du, Heng, Yan, Shiqiang, Sun, Qinru, Zhong, Changjia, Wu, Long, Vangavaragu, Jhansi Rani, Yan, Shijun, Hu, Gang, Guo, Lan, Rabinowitz, Molly, Glaser, Elzbieta, Arancio, Ottavio, Sosunov, Alexander A, McKhann, Guy M, Chen, John Xi, Yan, Shirley ShiDu

“…Accumulation of amyloid-β (Aβ) in synaptic mitochondria is associated with mitochondrial and synaptic injury. The underlying mechanisms and strategies to…”
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Amyloid-beta-induced mitochondrial dysfunction by Chen, John Xi, Yan, Shi Du

“…As an important molecule in the pathogenesis of Alzheimer's disease (AD), amyloid-beta (Abeta) interferes with multiple aspects of mitochondrial function,…”
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Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction by Origlia, Nicola, Righi, Massimo, Capsoni, Simona, Cattaneo, Antonino, Fang, Fang, Stern, David M, Chen, John Xi, Schmidt, Ann Marie, Arancio, Ottavio, Yan, Shi Du, Domenici, Luciano

“…Soluble amyloid-beta (Abeta) peptide is likely to play a key role during early stages of Alzheimer's disease (AD) by perturbing synaptic function and cognitive…”
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Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4⁺ T cells by Xu, Hongwei, Wu, Zhi-Ying, Fang, Fang, Guo, Lan, Chen, Doris, Chen, John Xi, Stern, David, Taylor, Gregory A, Jiang, Hong, Yan, Shirley ShiDu

“…The immunity-related GTPase Irgm1, also called LRG-47, is known to regulate host resistance to intracellular pathogens through multiple mechanisms that include…”
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Interaction of amyloid binding alcohol dehydrogenase/Aβ mediates up-regulation of peroxiredoxin II in the brains of Alzheimer’s disease patients and a transgenic Alzheimer’s disease mouse model by Yao, Jun, Taylor, Margaret, Davey, Fleur, Ren, Yimin, Aiton, Jim, Coote, Peter, Fang, Fang, Chen, John Xi, Yan, Shi Du, Gunn-Moore, Frank J.

“…Alzheimer’s patients have increased levels of both the 42 beta amyloid-β-peptide (Aβ) and amyloid binding alcohol dehydrogenase (ABAD) which is an…”
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Pathogenic role of mitochondrial [correction of mitochondral] amyloid-beta peptide by Chen, John Xi, Yan, Shi Du

“…Metabolic dysfunction is one of the early features in Alzheimer's disease (AD) affected brain. Amyloid-beta peptide (Abeta), a major peptide deposited in…”
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RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease by Yan, Shirley ShiDu, Chen, Doris, Yan, Shiqian, Guo, Lan, Du, Heng, Chen, John Xi

“…RAGE, a receptor for advanced glycation endproducts, is an immunoglobulin-like cell surface receptor that is often described as a pattern recognition receptor…”
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Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model by Yao, Jun, Taylor, Margaret, Davey, Fleur, Ren, Yimin, Aiton, Jim, Coote, Peter, Fang, Fang, Chen, John Xi, Yan, Shi Du, Gunn-Moore, Frank J

“…Alzheimer's patients have increased levels of both the 42 beta amyloid-beta-peptide (Abeta) and amyloid binding alcohol dehydrogenase (ABAD) which is an…”
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Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease by Yao, Jun, Du, Heng, Yan, Shiqiang, Fang, Fang, Wang, Chaodong, Lue, Lih-Fen, Guo, Lan, Chen, Doris, Stern, David M, Gunn Moore, Frank J, Xi Chen, John, Arancio, Ottavio, Yan, Shirley ShiDu

“…Amyloid-β (Aβ) peptide-binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, exacerbates Aβ-induced cell stress. The interaction of…”
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