Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence

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Published in:	Molecular and Cellular Biology Vol. 22; no. 10; pp. 3389 - 3403
Main Authors:	Wang, Weiping, Chen, Joan X., Liao, Rong, Deng, Qingdong, Zhou, Jennifer J., Huang, Shuang, Sun, Peiqing
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-05-2002 Taylor & Francis
Subjects:	Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Growth and Development Cell Size Cells, Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Enzyme Activation Fibroblasts - physiology Genes, ras - genetics Humans MAP Kinase Kinase 3 MAP Kinase Kinase 6 MAP Kinase Kinase Kinase 1 MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism Tumor Necrosis Factor-alpha - metabolism
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Summary:	Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology. For an alternate route to MCB .asm.org, visit: MCB
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Present address: Aurora Biosciences Corporation, San Diego, CA 92121. Corresponding author. Mailing address: Department of Molecular Biology, MB-41, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 91037. Phone: (858) 784-9710. Fax: (858) 784-9985. E-mail: pqsun@scripps.edu.
ISSN:	0270-7306 1098-5549 1098-5549
DOI:	10.1128/MCB.22.10.3389-3403.2002