Search Results - "Chen, Ivy X."

Dual Programmed Death Receptor‐1 and Vascular Endothelial Growth Factor Receptor‐2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma by Shigeta, Kohei, Datta, Meenal, Hato, Tai, Kitahara, Shuji, Chen, Ivy X., Matsui, Aya, Kikuchi, Hiroto, Mamessier, Emilie, Aoki, Shuichi, Ramjiawan, Rakesh R., Ochiai, Hiroki, Bardeesy, Nabeel, Huang, Peigen, Cobbold, Mark, Zhu, Andrew X., Jain, Rakesh K., Duda, Dan G.

“…Background and Aims Activation of the antitumor immune response using programmed death receptor‐1 (PD‐1) blockade showed benefit only in a fraction of patients…”
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Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy by Incio, Joao, Liu, Hao, Suboj, Priya, Chin, Shan M, Chen, Ivy X, Pinter, Matthias, Ng, Mei R, Nia, Hadi T, Grahovac, Jelena, Kao, Shannon, Babykutty, Suboj, Huang, Yuhui, Jung, Keehoon, Rahbari, Nuh N, Han, Xiaoxing, Chauhan, Vikash P, Martin, John D, Kahn, Julia, Huang, Peigen, Desphande, Vikram, Michaelson, James, Michelakos, Theodoros P, Ferrone, Cristina R, Soares, Raquel, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K

“…It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes…”
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Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma by Shigeta, Kohei, Matsui, Aya, Kikuchi, Hiroto, Klein, Sebastian, Mamessier, Emilie, Chen, Ivy X, Aoki, Shuichi, Kitahara, Shuji, Inoue, Koetsu, Shigeta, Ayako, Hato, Tai, Ramjiawan, Rakesh R, Staiculescu, Daniel, Zopf, Dieter, Fiebig, Lukas, Hobbs, Gabriela S, Quaas, Alexander, Dima, Simona, Popescu, Irinel, Huang, Peigen, Munn, Lance L, Cobbold, Mark, Goyal, Lipika, Zhu, Andrew X, Jain, Rakesh K, Duda, Dan G

“…Background and purposeCombining inhibitors of vascular endothelial growth factor and the programmed cell death protein 1 (PD1) pathway has shown efficacy in…”
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Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model by Li, Wende, Li, Sen, Chen, Ivy X, Liu, Yujiao, Ramjiawan, Rakesh R, Leung, Chi-Ho, Gerweck, Leo E, Fukumura, Dai, Loeffler, Jay S, Jain, Rakesh K, Duda, Dan G, Huang, Peigen

“…Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new…”
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Lymph node effective vascular permeability and chemotherapy uptake by Meijer, Eelco F. J., Blatter, Cedric, Chen, Ivy X., Bouta, Echoe, Jones, Dennis, Pereira, Ethel R., Jung, Keehoon, Vakoc, Benjamin J., Baish, James W., Padera, Timothy P.

“…Objective Lymph node metastases are a poor prognostic factor. Additionally, responses of lymph node metastasis to therapy can be different from the primary…”
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Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer by Chen, Ivy X., Chauhan, Vikash P., Posada, Jessica, Ng, Mei R., Wu, Michelle W., Adstamongkonkul, Pichet, Huang, Peigen, Lindeman, Neal, Langer, Robert, Jain, Rakesh K.

“…Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but the mechanisms remain unclear. Primary breast cancers are…”
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Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy by Chauhan, Vikash P., Chen, Ivy X., Tong, Rong, Ng, Mei Rosa, Martin, John D., Naxerova, Kamila, Wu, Michelle W., Huang, Peigen, Boucher, Yves, Kohane, Daniel S., Langer, Robert, Jain, Rakesh K.

“…Cancer-associated fibroblasts (CAFs) can either suppress or support T lymphocyte activity, suggesting that CAFs may be reprogrammable to an immunosupportive…”
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Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy by Ho, William W., Gomes-Santos, Igor L., Aoki, Shuichi, Datta, Meenal, Kawaguchi, Kosuke, Talele, Nilesh P., Roberge, Sylvie, Ren, Jun, Liu, Hao, Chen, Ivy X., Andersson, Patrik, Chatterjee, Sampurna, Kumar, Ashwin S., Amoozgar, Zohreh, Zhang, Qixian, Huang, Peigen, Ng, Mei Rosa, Chauhan, Vikash P., Xu, Lei, Duda, Dan G., Clark, Jeffrey W., Pittet, Mikael J., Fukumura, Dai, Jain, Rakesh K.

“…Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair–proficient (pMMR) CRCs make up about 95% of…”
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A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade by Chen, Ivy X., Newcomer, Kathleen, Pauken, Kristen E., Juneja, Vikram R., Naxerova, Kamila, Wu, Michelle W., Pinter, Matthias, Sen, Debattama R., Singer, Meromit, Sharpe, Arlene H., Jain, Rakesh K.

“…Immune checkpoint blockade (ICB) is efficacious in many diverse cancer types, but not all patients respond. It is important to understand the mechanisms…”
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Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models by Datta, Meenal, Chatterjee, Sampurna, Perez, Elizabeth M, Gritsch, Simon, Roberge, Sylvie, Duquette, Mark, Chen, Ivy X, Naxerova, Kamila, Kumar, Ashwin S, Ghosh, Mitrajit, Emblem, Kyrre E, Ng, Mei R, Ho, William W, Kumar, Pragya, Krishnan, Shanmugarajan, Dong, Xinyue, Speranza, Maria C, Neagu, Martha R, Iorgulescu, J Bryan, Huang, Raymond Y, Youssef, Gilbert, Reardon, David A, Sharpe, Arlene H, Freeman, Gordon J, Suvà, Mario L, Xu, Lei, Jain, Rakesh K

“…Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice…”
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FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS by Ferraro, Gino B, Ali, Ahmed, Luengo, Alba, Kodack, David P, Deik, Amy, Abbott, Keene L, Bezwada, Divya, Blanc, Landry, Prideaux, Brendan, Jin, Xin, Posada, Jessica M, Chen, Jiang, Chin, Christopher R, Amoozgar, Zohreh, Ferreira, Raphael, Chen, Ivy X, Naxerova, Kamila, Ng, Christopher, Westermark, Anna M, Duquette, Mark, Roberge, Sylvie, Lindeman, Neal I, Lyssiotis, Costas A, Nielsen, Jens, Housman, David E, Duda, Dan G, Brachtel, Elena, Golub, Todd R, Cantley, Lewis C, Asara, John M, Davidson, Shawn M, Fukumura, Dai, Dartois, Véronique A, Clish, Clary B, Jain, Rakesh K, Vander Heiden, Matthew G

“…Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and…”
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Solid stress impairs lymphocyte infiltration into lymph-node metastases by Jones, Dennis, Wang, Zixiong, Chen, Ivy X., Zhang, Sue, Banerji, Rohin, Lei, Pin-Ji, Zhou, Hengbo, Xiao, Victoria, Kwong, Cecilia, van Wijnbergen, Jan Willem M., Pereira, Ethel R., Vakoc, Benjamin J., Huang, Peigen, Nia, Hadi T., Padera, Timothy P.

“…Strong and durable anticancer immune responses are associated with the generation of activated cancer-specific T cells in the draining lymph nodes. However,…”
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Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin by Saif, Mari, Kwanten, Wilhelmus J., Carr, Jessica A., Chen, Ivy X., Posada, Jessica M., Srivastava, Amitabh, Zhang, Juanye, Zheng, Yi, Pinter, Matthias, Chatterjee, Sampurna, Softic, Samir, Kahn, C. Ronald, van Leyen, Klaus, Bruns, Oliver T., Jain, Rakesh K., Bawendi, Moungi G.

“…Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the…”
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Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis by Ferraro, Gino B, Ali, Ahmed, Luengo, Alba, Kodack, David P, Deik, Amy, Abbott, Keene L, Bezwada, Divya, Blanc, Landry, Prideaux, Brendan, Jin, Xin, Posada, Jessica M, Chen, Jiang, Chin, Christopher R, Amoozgar, Zohreh, Ferreira, Raphael, Chen, Ivy X, Naxerova, Kamila, Ng, Christopher, Westermark, Anna M, Duquette, Mark, Roberge, Sylvie, Lindeman, Neal I, Lyssiotis, Costas A, Nielsen, Jens, Housman, David E, Duda, Dan G, Brachtel, Elena, Golub, Todd R, Cantley, Lewis C, Asara, John M, Davidson, Shawn M, Fukumura, Dai, Dartois, Véronique A, Clish, Clary B, Jain, Rakesh K, Vander Heiden, Matthew G

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Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin by Saif, Mari, Kwanten, Wilhelmus J., Carr, Jessica A., Chen, Ivy X., Posada, Jessica M., Srivastava, Amitabh, Zhang, Juanye, Zheng, Yi, Pinter, Matthias, Chatterjee, Sampurna, Softic, Samir, Kahn, C. Ronald, van Leyen, Klaus, Bruns, Oliver T., Jain, Rakesh K., Bawendi, Moungi G.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41551-020-0569-y…”
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Abstract 2744: Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer by Chen, Ivy X., Chauhan, Vikash P., Posada, Jessica, Ng, Mei R., Wu, Michelle, Adstamongkonkul, Pichet, Huang, Peigen, Lindeman, Neal, Langer, Robert, Jain, Rakesh K.

“…Abstract Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but the mechanisms remain unclear. Primary breast cancers are…”
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Abstract PO-097: Addition of losartan to FOLFIRINOX and chemoradiation reduces the expression of pro-invasive and immunosuppressive genes in locally-advanced pancreatic cancer by Boucher, Yves, Posada, Jessica M., Subudhi, Sonu, Kumar, Ashwin S., Chen, Ivy X., Ng, Mei R., Mino-Kenudson, Mari, Talele, Nilesh, Duda, Dan G., Fukumura, Dai, Murphy, Janet E., Clark, Jeffrey W., Ryan, David P., Fernandez-Del Castillo, Carlos, Hong, Theodore S., Jain, Rakesh K.

“…Abstract Purpose: A phase II trial in patients with locally-advanced pancreatic cancer (LAPC) revealed unprecedented rates of complete surgical resection after…”
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Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC by Shigeta, Kohei, Datta, Meenal, Hato, Tai, Kitahara, Shuji, Chen, Ivy X., Matsui, Aya, Kikuchi, Hiroto, Mamessier, Emilie, Aoki, Shuichi, Ramjiawan, Rakesh R., Ochiai, Hiroki, Bardeesy, Nabeel, Huang, Peigen, Cobbold, Mark, Zhu, Andrew X., Jain, Rakesh K., Duda, Dan G.

“…Activation of anti-tumor immune response using programmed death receptor-1 (PD-1) blockade showed benefit only in a fraction of hepatocellular carcinoma (HCC)…”
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Noninvasive monitoring of chronic liver disease via near and shortwave-infrared imaging of endogenous lipofuscin by Saif, Mari, Kwanten, Wilhelmus J., Carr, Jessica A., Chen, Ivy X., Posada, Jessica M., Srivastava, Amitabh, Zhang, Juanye, Zheng, Yi, Pinter, Matthias, Chatterjee, Sampurna, Softic, Samir, Kahn, C. Ronald, van Leyen, Klaus, Bruns, Oliver T., Jain, Rakesh K., Bawendi, Moungi G.

“…The monitoring of the progression of non-alcoholic fatty liver disease is hindered by the lack of suitable noninvasive imaging methods. Here, we show that the…”
Get full text