Search Results - "Chen, Huaiwen"

Mastocarcinoma therapy synergistically promoted by lysosome dependent apoptosis specifically evoked by 5-Fu@nanogel system with passive targeting and pH activatable dual function by Zhu, Xiandi, Sun, Yn, Chen, Di, Li, Jingfeng, Dong, Xia, Wang, Jie, Chen, Huaiwen, Wang, Ying, Zhang, Fulei, Dai, Jinaxin, Pirraco, Rogério P., Guo, Shangjing, Marques, Alexandra P., Reis, Rui L., Li, Wei

“…[Display omitted] This manuscript describes a synergistic therapy for mastocarcinoma by pH and temperature dual-sensitive nanogel, and effects of…”
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The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors by Li, Wei, Li, Jinfeng, Gao, Jie, Li, Bohua, Xia, Yu, Meng, Yanchun, Yu, Yongsheng, Chen, Huaiwen, Dai, Jianxin, Wang, Hao, Guo, Yajun

“…Abstract Focusing on high temperature and low pH of tumor tissue, we prepared temperature and pH responsive poly(N-isopropylacrylamide- co…”
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Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA by Gao, Jie, Chen, Huaiwen, Yu, Yongsheng, Song, Jinjing, Song, Hao, Su, Xiao, Li, Wei, Tong, Xin, Qian, Weizhu, Wang, Hao, Dai, Jianxin, Guo, Yajun

“…Abstract The chemotherapy combined with gene therapy has received great attention. We developed targeted LPD (liposome-polycation-DNA complex) conjugated with…”
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The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes by Gao, Jie, Liu, Wei, Xia, Yu, Li, Wei, Sun, Jing, Chen, Huaiwen, Li, Bohua, Zhang, Dapeng, Qian, Weizhu, Meng, Yanchun, Deng, Li, Wang, Hao, Chen, Jianming, Guo, Yajun

“…Abstract The LPD (liposome-polycation-DNA complex) is an effective nanovector for systemically small interfering RNA (siRNA) delivery which was well…”
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Cross-linking N-succinyl chitosan-oxidated hyaluronic acid-based hydrogel loaded with bone marrow mesenchymal stem cell-derived exosomes induce bone regeneration in cranial defects by Chu, Xiao-yang, Yang, Kai, He, Xin, Yu, Kai-tao, Luan, Ying-yi, He, Qing-bing, Li, Ze-lu, Xiang, Yu-lan, Chen, Huaiwen, Zeng, Yang, Li, Ya-Zhou, Zhang, Dong-liang

“…[Display omitted] •BMSCs-Exo-loaded hydrogel had self-healing, compressive, and adhesive properties.•BMSCs-Exo-loaded hydrogel promoted the osteogenic…”
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Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma by Gao, Jie, Xia, Yu, Chen, Huaiwen, Yu, Yongsheng, Song, Jinjing, Li, Wei, Qian, Weizhu, Wang, Hao, Dai, Jianxin, Guo, Yajun

“…The aim of this study was to obtain adriamycin-loaded polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody (PLNP-Mal-EGFR) for…”
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Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods by Zhang, Fulei, Hou, Yi, Zhu, Minhui, Deng, Bo, Zhao, Mengxin, Zhu, Xiandi, Sun, Yun, Chen, Di, Jiang, Cheng, Wang, Liming, Chen, Chunying, Chen, Huaiwen, Chen, Han, Zheng, Hongliang, Li, Wei

“…Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis…”
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Integrated radiochemotherapy study of ZIF-8 coated with osteosarcoma-platelet hybrid membranes for the delivery of Dbait and Adriamycin by Du, Longhai, Zhu, Guanghao, Xu, Yanlong, Han, Binxu, Wang, Yu, Zhu, Minhui, Meng, Yingdi, Chen, Huaiwen, Yu, Zuochong

“…The toxic side effects of systemic high-dose chemotherapy and poor sensitivity to radiotherapy hinder the survival rate of patients with osteosarcoma (OS)…”
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Antibody-targeted immunoliposomes for cancer treatment by Gao, Jie, Chen, Huaiwen, Song, Hao, Su, Xiao, Niu, Fangfang, Li, Wei, Li, Bohua, Dai, Jianxin, Wang, Hao, Guo, Yajun

“…Monoclonal antibodies (mAbs) or their derivatives are often used as the targeted ligands in the ligand targeted liposomes (LTLs). LTLs modified with mAbs or…”
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Preparation and characterization of PE38KDEL-loaded anti-HER2 nanoparticles for targeted cancer therapy by Chen, Huaiwen, Gao, Jie, Lu, Ying, Kou, Geng, Zhang, He, Fan, Li, Sun, Zhiguo, Guo, Yajun, Zhong, Yanqiang

“…The clinical use of immunotoxins is severely limited by nonspecific toxicity. To overcome this limitation, PE38KDEL was used as a model protein toxin to…”
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PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumor progression with reduced toxicity and immunogenicity by Gao, Jie, Kou, Geng, Wang, Hao, Chen, Huaiwen, Li, Bohua, Lu, Ying, Zhang, Dapeng, Wang, Shuhui, Hou, Sheng, Qian, Weizhu, Dai, Jianxin, Zhao, Jian, Zhong, Yanqiang, Guo, Yajun

“…The clinical use of Pseudomonas exotoxin A (PE)-based immunotoxins is limited by the toxicity and immunogenicity of PE. To overcome the limitations, we have…”
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Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab′) fragments by Gao, Jie, Kou, Geng, Chen, Huaiwen, Wang, Hao, Li, Bohua, Lu, Ying, Zhang, Dapeng, Wang, Shuhui, Hou, Sheng, Qian, Weizhu, Dai, Jianxin, Zhao, Jian, Zhong, Yanqiang, Guo, Yajun

“…We reported previously the development of SMFv-PE38KDEL type I mutant (PE38KDEL-I; Mut-I), a recombinant immunotoxin in which a single-chain antibody derived…”
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Oligomer nanoparticle release from polylactic acid plastics catalysed by gut enzymes triggers acute inflammation by Wang, Mengjing, Li, Qianqian, Shi, Changzhi, Lv, Jia, Xu, Youdong, Yang, Junjie, Chua, Shae Linn, Jia, Linran, Chen, Huaiwen, Liu, Qian, Huang, Changjin, Huang, Yichao, Chen, Jianmin, Fang, Mingliang

“…The health risks of exposure to ‘eco-friendly’ biodegradable plastics of anthropogenic origin and their effects on the gastrointestinal tract are largely…”
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Targeted salinomycin delivery with EGFR and CD133 aptamers based dual-ligand lipid-polymer nanoparticles to both osteosarcoma cells and cancer stem cells by Chen, Fangyi, Zeng, Yibin, Qi, Xiaoxia, Chen, Yanchao, Ge, Zhe, Jiang, Zengxin, Zhang, Xinchao, Dong, Yinmei, Chen, Huaiwen, Yu, Zuochong

“…We previously developed salinomycin (sali)-entrapped nanoparticles labeled with CD133 aptamers which could efficiently eliminate CD133+ osteosarcoma cancer…”
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Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles by Zhou, Jie, Sun, Jin, Chen, Huaiwen, Peng, Qing

“…As the leading cause of cancer-associated mortality worldwide, lung cancer is often associated with therapy failure and decreases in survival; these factors…”
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Therapeutic effect of E-Lip-siRNA-sFlt1 on pre-eclampsia: targeted gene silencing and improved pregnancy outcomes by Dong, Jinhua, Zhang, Yingying, Zhou, Jingsheng, Mao, Shuhui, Tang, Jianfen, Li, Suping, Ma, Qiang, Ai, Ling, Wang, Wei, Zhu, Guanghao, Shao, Huijing, Meng, Yingdi, Chen, Huaiwen, Chen, Danqing

“…To evaluate a liposome complex conjugated with anti-epidermal growth factor receptor (EGFR) antibodies for the treatment of pre-eclampsia (PE). In experiments,…”
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The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles by Jiang, Jianxin, Chen, Huaiwen, Yu, Chao, Zhang, Yingying, Chen, Meiyuan, Tian, She, Sun, Chengyi

“…To develop salinomycin-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with both CD133 aptamers A15 and EGFR aptamers CL4 (CESN), to target…”
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EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma by Gao, Jie, Yu, Yongsheng, Zhang, Yingying, Song, Jinjing, Chen, Huaiwen, Li, Wei, Qian, Weizhu, Deng, Li, Kou, Geng, Chen, Jianming, Guo, Yajun

“…Abstract The development of immunoliposomes for systemic siRNA (small interfering RNA) delivery is highly desired. We reported previously the development of…”
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Polymer-Lipid Hybrid Theranostic Nanoparticles Co-Delivering Ultrasmall Superparamagnetic Iron Oxide and Paclitaxel for Targeted Magnetic Resonance Imaging and Therapy in Atherosclerotic Plaque by Dong, Yinmei, Chen, Huaiwen, Chen, Chao, Zhang, Xuefeng, Tian, Xia, Zhang, Yingying, Shi, Zhang, Liu, Qi

“…Magnetic resonance imaging (MRI) combined with ultrasmall superparamagnetic iron oxide (USPIO) is effective for the detection of atherosclerotic (AS) plaque,…”
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Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells by Ni, Miaozhong, Xiong, Min, Zhang, Xinchao, Cai, Guoping, Chen, Huaiwen, Zeng, Qingmin, Yu, Zuochong

“…Cancer stem cells (CSCs) possess the characteristics associated with normal stem cells and are responsible for cancer initiation, recurrence, and metastasis…”
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