Search Results - "Chen, HouZao"

Caloric restriction, Sirtuins, and cardiovascular diseases by Wei, Ziyu, Yang, Bo, Wang, Huiyu, Lv, Shuangjie, Chen, Houzao, Liu, Depei

“…Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases,…”
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Oxidative stress in atrial fibrillation: An emerging role of NADPH oxidase by Youn, Ji-Youn, Zhang, Jun, Zhang, Yixuan, Chen, Houzao, Liu, Depei, Ping, Peipei, Weiss, James N, Cai, Hua

“…Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia. Patients with AF have up to seven-fold higher risk of suffering from ischemic stroke…”
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Smooth Muscle Sirtuin 1 Blocks Thoracic Aortic Aneurysm/Dissection Development in Mice by Wang, Fang, Tu, Yimin, Gao, Yanxiang, Chen, Houzao, Liu, Jinjing, Zheng, Jingang

“…Purpose Advancing age is the major risk factor for thoracic aortic aneurysm/dissection (TAAD). However, the causative link between age-related molecules and…”
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Publisher Correction: Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage by Gong, Ke, Xue, Chao, Feng, Zian, Pan, Ruru, Wang, Mengyao, Chen, Shasha, Chen, Yuanli, Guan, Yudong, Dai, Lingyun, Zhang, Shuang, Jiang, Liwei, Li, Ling, Wang, Bei, Yin, Zequn, Ma, Likun, Iwakiri, Yasuko, Tang, Junming, Liao, Chenzhong, Chen, Houzao, Duan, Yajun

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Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage by Gong, Ke, Xue, Chao, Feng, Zian, Pan, Ruru, Wang, Mengyao, Chen, Shasha, Chen, Yuanli, Guan, Yudong, Dai, Lingyun, Zhang, Shuang, Jiang, Liwei, Li, Ling, Wang, Bei, Yin, Zequn, Ma, Likun, Iwakiri, Yasuko, Tang, Junming, Liao, Chenzhong, Chen, Houzao, Duan, Yajun

“…Glucagon-like peptide 1 (GLP1), which is mainly processed and cleaved from proglucagon in enteroendocrine cells (EECs) of the intestinal tract, acts on the…”
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Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia by Xue, Chao, Zeng, Peng, Gong, Ke, Li, Qian, Feng, Zian, Wang, Mengyao, Chen, Shasha, Yang, Yanfang, Li, Jiaqi, Zhang, Shuang, Yin, Zequn, Liang, Yingquan, Yan, Tengteng, Yu, Miao, Feng, Ke, Zhao, Dan, Yang, Xiaoxiao, Zhang, Xia, Ma, Likun, Iwakiri, Yasuko, Chen, Liang, Tang, Xiaoqiang, Chen, Yuanli, Chen, Houzao, Duan, Yajun

“…The strategy of lowering cholesterol levels by promoting cholesterol excretion is still lacking, and few molecular targets act on multiple cholesterol…”
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Genetic analysis of the SIRT1 gene promoter in myocardial infarction by Cui, Yinghua, Wang, Haihua, Chen, Houzao, Pang, Shuchao, Wang, Lin, Liu, Depei, Yan, Bo

“…► SIRT1 gene promoter was genetically analyzed in MI patients and controls. ► Five novel heterozygous variants and one SNP were only identified in MI patients…”
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Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence by Chen, HouZao, Wan, YanZhen, Zhou, Shuang, Lu, YunBiao, Zhang, ZhuQin, Zhang, Ran, Chen, Feng, Hao, DeLong, Zhao, Xiang, Guo, ZhiChen, Liu, DePei, Liang, ChihChuan

“…The rapidly increasing prevalence of diabetes mellitus worldwide is one of the most serious and challenging health problems in the 21st century. Mammalian…”
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Baicalein protects against the development of angiotensin II-induced abdominal aortic aneurysms by blocking JNK and p38 MAPK signaling by Wang, Fang, Chen, Houzao, Yan, Yunfei, Liu, Yue, Zhang, Shuyang, Liu, Depei

“…An abdominal aortic aneurysm（AAA） is a permanent, localized dilatation of the abdominal aorta. In western countries, the morbidity of AAA is approximately 8%…”
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Extracellular matrix turnover in coronary artery ectasia patients by Liu, Ruifeng, Chen, Lianfeng, Wu, Wei, Chen, Houzao, Zhang, Shuyang

“…Dysregulation of the metabolism of the extracellular matrix (ECM) may contribute to coronary artery ectasia (CAE). This study evaluated the turnover of main…”
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Vascular Transcriptome Profiling Reveals Aging-Related Genes in Angiotensin Ⅱ-Induced Hypertensive Mouse Aortas by Lv, Shuang Jie, Ding, Yang Nan, Pei, Xiao Ya, Zhao, Xiang, Hao, De Long, Zhang, Zhu Qin, Chen, Hou Zao, Liu, De Pei

“…Objective Angiotensin Ⅱ (Ang Ⅱ)-induced vascular damage is a major risk of hypertension. However, the underlying molecular mechanism of AngⅡ-induced vascular…”
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A vascular endothelial growth factor activating transcription factor increases the endothelial progenitor cells population and induces therapeutic angiogenesis in a type 1 diabetic mouse with hindlimb ischemia by Diao, Yongpeng, Lian, Lishan, Guo, Lilong, Chen, Houzao, Chen, Yuexin, Song, Xiaojun, Li, Yongjun

“…Background Therapeutic angiogenesis has been shown to promote blood vessel growth and improve tissue perfusion. Vascular endothelial growth factor （VEGF） plays…”
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SIRT1 inhibits angiotensin Ⅱ-induced vascular smooth muscle cell hypertrophy by Li, Li, Gao, Peng, Zhang, Huina, Chen, Houzao, Zheng, Wei, Lv, Xiang, Xu, Tingting, Wei, Yusheng, Liu, Depei, Liang, Chihchuan

“…Angiotensin Ⅱ （Ang Ⅱ） stimulates vascular smooth muscle cell （VSMC） hypertrophy as a critical event in the development of vascular diseases such as…”
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Mechanistic perspectives of calorie restriction on vascular homeostasis by Liu, Yue, Chen, HouZao, Liu, DePei

“…Calorie restriction（CR）is a dietary regime based on low calorie intake.CR without malnutrition extends lifespan in a wide range of organisms from yeast to…”
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Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure by Mu, WenLi, Zhang, QingJun, Tang, XiaoQiang, Fu, WenYan, Zheng, Wei, Lu, YunBiao, Li, HongLiang, Wei, YuSheng, Li, Li, She, ZhiGang, Chen, HouZao, Liu, DePei

“…SIRT1, a mammalian ortholog of yeast silent information regulator 2 （Sir2）, is an NAD＋-dependent protein deacetylase that plays a critical role in the…”
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SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells by Jia, YuYan, Gao, Peng, Chen, HouZao, Wan, YanZhen, Zhang, Ran, Zhang, ZhuQin, Yang, RuiFeng, Wang, Xu, Xu, Jing, Liu, DePei

“…Intercellular adhesion molecule-1 （ICAM-1） plays an important role in the recruitment of leukocytes to the endothelium, which causes inflammation and…”
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Translational research： Lessons from past research, growing up nowadays, and development goal in future by Zhang, ZhuQin, Chen, HouZao, Liu, DePei

“…Recently, with coming of the ＂omics＂ era and rapid devel- opment of basic research in biology and medicine, huge information about biology and life has been…”
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Two novel cis-elements involved in hepatocyte nuclear factor 4α regulation of acyl-coenzyme A：cholesterol acyltransferase 2 expression by Zhang, Zhuqin, Liu, Jinjing, Xi, Yang, Yang, Ruifeng, Chen, Houzao, Li, Zhenya, Liu, Depei, Liang, Chihchuan

“…Acyl-coenzyme A：cholesterol acyltransferase 2 （ACAT2） is important for cholesterol ester synthesis and secretion. A previous study revealed that ACAT2 gene…”
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SIRT1 and gynecological malignancies (Review) by Chen, Jiayu, Chen, Houzao, Pan, Lingya

“…Sirtuin 1 (SIRT1), a member of the sirtuin protein family, is a nicotinamide adenine dinucleotide (NAD )‑dependent type III histone deacetylase and…”
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The histone deacetylase inhibitor belinostat ameliorates experimental autoimmune encephalomyelitis in mice by inhibiting TLR2/MyD88 and HDAC3/ NF-κB p65-mediated neuroinflammation by Shen, Yanjia, Yang, Ran, Zhao, Jiaying, Chen, Miao, Chen, Shuhan, Ji, Baixi, Chen, Houzao, Liu, Depei, Li, Li, Du, Guanhua

“…Multiple sclerosis (MS) is a Th cell-mediated inflammatory demyelinating autoimmune disease. MS cannot be cured, and long-term drug treatment is still needed…”
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