Search Results - "Chen, Holly Y."

Primary cilia biogenesis and associated retinal ciliopathies by Chen, Holly Y., Kelley, Ryan A., Li, Tiansen, Swaroop, Anand

“…[Display omitted] The primary cilium is a ubiquitous microtubule-based organelle that senses external environment and modulates diverse signaling pathways in…”
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Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo by Brooks, Matthew J., Chen, Holly Y., Kelley, Ryan A., Mondal, Anupam K., Nagashima, Kunio, De Val, Natalia, Li, Tiansen, Chaitankar, Vijender, Swaroop, Anand

“…Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but lack functional maturation of distinct cell types, especially…”
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Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects by Chen, Holly Y, Swaroop, Manju, Papal, Samantha, Mondal, Anupam K, Song, Hyun Beom, Campello, Laura, Tawa, Gregory J, Regent, Florian, Shimada, Hiroko, Nagashima, Kunio, de Val, Natalia, Jacobson, Samuel G, Zheng, Wei, Swaroop, Anand

“…Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ pathologies, with retinal degeneration a highly penetrant phenotype…”
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Nicotinamide Promotes Formation of Retinal Organoids From Human Pluripotent Stem Cells via Enhanced Neural Cell Fate Commitment by Regent, Florian, Batz, Zachary, Kelley, Ryan A., Gieser, Linn, Swaroop, Anand, Chen, Holly Y., Li, Tiansen

“…Retinal organoids (ROs) derived from human pluripotent stem cells (hPSCs) recapitulate key features of retinogenesis and provide a promising platform to study…”
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Cell-cell interaction in the pathogenesis of inherited retinal diseases by Du, Xue, Butler, Anna G, Chen, Holly Y

“…The retina is part of the central nervous system specialized for vision. Inherited retinal diseases (IRD) are a group of clinically and genetically…”
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Genetics and therapy for pediatric eye diseases by Chen, Holly.Y., Lehmann, Ordan J., Swaroop, Anand

“…Ocular morphogenesis in vertebrates is a highly organized process, orchestrated largely by intrinsic genetic programs that exhibit stringent spatiotemporal…”
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Accelerated Development of Rod Photoreceptors in Retinal Organoids Derived from Human Pluripotent Stem Cells by Supplementation with 9-cis Retinal by Kelley, Ryan A., Chen, Holly Y., Swaroop, Anand, Li, Tiansen

“…Human pluripotent stem cells (PSCs) can be differentiated into retinal organoids with proper neural layer organization, yet the protocols are technically…”
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The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model by Chen, Holly Y., Ma, Suk Ling, Huang, Wei, Ji, Lindan, Leung, Vincent H. K., Jiang, Honglin, Yao, Xiaoqiang, Tang, Nelson L. S.

“…Functional short tandem repeats (STR) are polymorphic in the population, and the number of repeats regulates the expression of nearby genes (known as…”
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HIPRO: A High-Efficiency, Hypoxia-Induced Protocol for Generation of Photoreceptors in Retinal Organoids from Mouse Pluripotent Stem Cells by Chen, Holly Y., Kelley, Ryan A., Swaroop, Anand

“…Mouse pluripotent stem cells can be efficiently differentiated into retinal organoids with polarized, laminated neural retina harboring all retinal cell types…”
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A simple and efficient method for generating human retinal organoids by Regent, Florian, Chen, Holly Y, Kelley, Ryan A, Qu, Zepeng, Swaroop, Anand, Li, Tiansen

“…Retinal organoids (ROs) derived from human pluripotent stem cells largely recapitulate key features of in vivo retinal development, thus permitting the study…”
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Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal by Kaya, Koray D, Chen, Holly Y, Brooks, Matthew J, Kelley, Ryan A, Shimada, Hiroko, Nagashima, Kunio, de Val, Natalia, Drinnan, Charles T, Gieser, Linn, Kruczek, Kamil, Erceg, Slaven, Li, Tiansen, Lukovic, Dunja, Adlakha, Yogita K, Welby, Emily, Swaroop, Anand

“…Retinal organoids generated from human pluripotent stem cells exhibit considerable variability during differentiation. Our goals are to assess developmental…”
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Haplotype effect in the IGF1 promoter accounts for the association between microsatellite and serum IGF1 concentration by Chen, Holly Y., Chan, Iris H. S., Sham, Aprille L. K., Leung, Vincent H. K., Ma, Suk L., Ho, Suzanne C., Tang, Nelson L. S.

“…Summary Objective  Systemic insulin‐like growth factor 1 (IGF1) level is an important risk factor for various diseases. The inter‐individual variation of serum…”
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Functional Interaction Between SNPs and Microsatellite in the Transcriptional Regulation of Insulin-Like Growth Factor 1 by Chen, Holly Y., Huang, Wei, Leung, Vincent H. K., Fung, Simon L. M., Ma, Suk Ling, Jiang, Hongling, Tang, Nelson L. S.

“…ABSTRACT A CA‐repeat microsatellite in insulin‐like growth factor 1 (IGF1) promoter was associated with interindividual variation of circulating IGF1 level…”
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Haplotype effect in the IGF1 promoter accounts for the association between microsatellite and serum IGF1 concentration: Association between genetic variations and serum IGF1 concentration by Chen, Holly Y., Chan, Iris H. S., Sham, Aprille L. K., Leung, Vincent H. K., Ma, Suk L., Ho, Suzanne C., Tang, Nelson L. S.

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